MolNFT v1 · #182753 · protein

Crystal structure of wild-type human GAMMA(S)-crystallin

7N36 · Gamma-crystallin S: “Crystal structure of wild-type human GAMMA(S)-crystallin”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #182753 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7N36
Type: protein
Length: 348 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-crystallin S
UniProt: P22914
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Gamma-crystallin S	protein	174	10% helix, 49% strand	P22914

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	302	0.52	0.74	47	empty
2	67	0.32	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 601 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7N36 · Crystal structure of wild-type human gamma(S)-crystallin · the same entry in another collection · chain A against A, TM-score 1.00
P22914 · AlphaFold monomer V2.0 prediction for gamma-crystallin S (P22914) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22914
Elsewhere: RCSB PDB 7N36 · PDBe 7N36 · UniProt P22914

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