UniProt P22455
Fibroblast growth factor receptor 4 (P22455)
Fibroblast growth factor receptor 4 (UniProt P22455), EC 2.7.10.1: 64 experimental structures and 1 predicted model on GenesisL1, 24 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22455
- Protein
- Fibroblast growth factor receptor 4
- EC
- 2.7.10.1
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 24
- Pockets
- 24 · 8 records with a druggable one
Structures
65 records of P22455 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4QQ5 | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in… | x-ray diffraction | A | — | — |
| 4QQ5 | Crystal structure of FGF receptor (fgfr) 4 kinase harboring the V550L gate-keeper mutation in… | x-ray diffraction | A | — | — |
| 4QQC | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible… | x-ray diffraction | A | — | — |
| 4QQC | Crystal structure of FGF receptor (fgfr) 4 kinase domain in complex with fiin-2, an irreversible… | x-ray diffraction | A | — | — |
| 4QQJ | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation | x-ray diffraction | A | — | — |
| 4QQJ | Crystal structure of FGF receptor (fgfr) 4 kinase domain harboring the V550L gate-keeper mutation | x-ray diffraction | A | — | — |
| 4QQT | Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain | x-ray diffraction | A | — | — |
| 4QQT | Crystal structure of FGF receptor (fgfr) 4 tyrosine kinase domain | x-ray diffraction | A | — | — |
| 4QRC | Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib | x-ray diffraction | A | — | — |
| 4QRC | Crystal structure of the tyrosine kinase domain of FGF receptor 4 in complex with ponatinib | x-ray diffraction | A | — | — |
| 4R6V | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in… | x-ray diffraction | A | — | — |
| 4R6V | Crystal structure of FGF receptor (fgfr) 4 kinase harboring the V550L gate-keeper mutation in… | x-ray diffraction | A | — | — |
| 4TYE | Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | x-ray diffraction | A | — | — |
| 4TYE | Structural analysis of the human fibroblast growth factor receptor 4 kinase | x-ray diffraction | A | — | — |
| 4TYG | Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | x-ray diffraction | A | — | — |
| 4TYG | Structural analysis of the human fibroblast growth factor receptor 4 kinase | x-ray diffraction | A | — | — |
| 4TYI | Structural analysis of the human Fibroblast Growth Factor Receptor 4 | x-ray diffraction | A | — | — |
| 4TYI | Structural analysis of the human fibroblast growth factor receptor 4 | x-ray diffraction | A | — | — |
| 4TYJ | Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | x-ray diffraction | A | — | — |
| 4TYJ | Structural analysis of the human fibroblast growth factor receptor 4 kinase | x-ray diffraction | A | — | — |
| 4UXQ | FGFR4 in complex with Ponatinib | x-ray diffraction | A | — | — |
| 4UXQ | FGFR4 in complex with ponatinib | x-ray diffraction | A | — | — |
| 4XCU | Crystal Structure of FGFR4 with an Irreversible Inhibitor | x-ray diffraction | A | — | — |
| 4XCU | Crystal structure of FGFR4 with an irreversible inhibitor | x-ray diffraction | A | — | — |
| 5JKG | The crystal structure of FGFR4 kinase domain in complex with LY2874455 | x-ray diffraction | A | 6LF | — |
| 5JKG | The crystal structure of FGFR4 kinase domain in complex with LY2874455 | x-ray diffraction | A | — | — |
| 5NUD | Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand… | x-ray diffraction | A, B | 99K | — |
| 5NUD | Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand… | x-ray diffraction | A, B | 99K | — |
| 5NWZ | Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand… | x-ray diffraction | A, B | 9CT | — |
| 5NWZ | Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand… | x-ray diffraction | A, B | 9CT | — |
| 5XFF | Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550L) | x-ray diffraction | A | 6LF | — |
| 5XFJ | Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550M) | x-ray diffraction | A | 6LF | — |
| 6IUO | Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor | x-ray diffraction | A | AWX | — |
| 6IUO | Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor | x-ray diffraction | A | AWX | — |
| 6IUP | Crystal structure of FGFR4 kinase domain in complex with compound 5 | x-ray diffraction | A | AX0 | — |
| 6IUP | Crystal structure of FGFR4 kinase domain in complex with compound 5 | x-ray diffraction | A | AX0 | — |
| 6J6Y | FGFR4 D2 - Fab complex | x-ray diffraction | A, D | — | — |
| 6J6Y | FGFR4 D2 - Fab complex | x-ray diffraction | A, D | — | — |
| 6JPE | Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1 | x-ray diffraction | A | BYU, SO4 | — |
| 6JPJ | Crystal structure of FGF401 in complex of FGFR4 | x-ray diffraction | A | SO4 | — |
| 6NVG | FGFR4 complex with N-(3,5-dichloro-2-((5-((2,6-dichloro-3,5… | x-ray diffraction | A | SO4, XL8 | — |
| 6NVH | FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-DIMETHOXYBENZYL)OXY)… | x-ray diffraction | A | SO4, XL6 | — |
| 6NVI | FGFR4 complex with N-(3-chloro-2-((5-((2,6-dichloro-3,5… | x-ray diffraction | A | XL7, SO4 | — |
| 6NVJ | FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-DIMETHOXYBENZYL)OXY)… | x-ray diffraction | A | SO4, XL5 | — |
| 6NVK | FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino… | x-ray diffraction | A | SO4, XL9 | 2 (best 0.60) |
| 6NVK | FGFR4 complex with blu-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5… | x-ray diffraction | A | SO4, XL9 | — |
| 6V9C | Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor | x-ray diffraction | A | QS7, SO4 | — |
| 6YI8 | Human FGFR4 kinase domain (447-753) in complex with roblitinib | x-ray diffraction | A, B | SO4 | — |
| 7DTZ | FGFR4 complex with a covalent inhibitor | x-ray diffraction | A | HHL, SO4 | — |
| 7F3M | Crystal structure of FGFR4 kinase domain with PRN1371 | x-ray diffraction | A | GX3, SO4 | — |
| 7N1J | Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder | x-ray diffraction | A, C | — | 1 (best 0.62) |
| 7N1J | Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder | x-ray diffraction | A, C | — | — |
| 7V29 | Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | x-ray diffraction | B, A | 5JR, SO4 | 4 (best 0.75) |
| 7V29 | Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | x-ray diffraction | B, A | 5JR, SO4 | — |
| 7VJL | The crystal structure of FGFR4 kinase domain in complex with… | x-ray diffraction | A, B | 7IF | 3 (best 0.52) |
| 7VJL | The crystal structure of FGFR4 kinase domain in complex with N-(5… | x-ray diffraction | A, B | 7IF | — |
| 7WCT | Crystal structure of FGFR4 kinase domain with 7V | x-ray diffraction | A | 90F, SO4 | — |
| 7WCW | Crystal structure of FGFR4(V550L) kinase domain with 7v | x-ray diffraction | A | 90F, SO4 | — |
| 7WCW | Crystal structure of FGFR4(V550L) kinase domain with 7V | x-ray diffraction | A | 90F, SO4 | — |
| 7WCX | Crystal structure of FGFR4(V550M) kinase domain with 7V | x-ray diffraction | A | 90F, SO4 | — |
5 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 21 records
- 90F · ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide · in 4 records
- 6LF · 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol · in 3 records
- 5JR · N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide · in 2 records
- 7IF · N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide · in 2 records
- 99K · 3-chloranyl-~{N}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine · in 2 records
- 9CT · ~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide · in 2 records
- AWX · N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide · in 2 records
- AX0 · N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide · in 2 records
- XL9 · N-[(3S,4S)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl) quinazolin-2-yl]amino}oxan-4-yl]propanamide · in 2 records
- A1LVQ · Cxf007 · in 1 record
- BYU · N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide · in 1 record
- CU · Copper (II) ion · in 1 record
- GX3 · 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl) propyl]pyrido[2,3-d]pyrimidin-7-one · in 1 record
- HHL · N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide · in 1 record
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 1 record
- IIQ · ~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-propyl-pyrrolo[3,2-b]pyridine-3-carboxamide · in 1 record
- IIW · 6-bromanyl-~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide · in 1 record
- QS7 · N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide · in 1 record
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 1 record
- XL5 · N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl) methoxy]pyrimidin-2-yl}amino)-3-fluorophenyl]propanamide · in 1 record
- XL6 · N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl) methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide · in 1 record
- XL7 · N-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl) methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide · in 1 record
- XL8 · N-[3,5-dichloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino) phenyl]propanamide · in 1 record
Experiment against prediction
- 6J6Y chain D against the predicted model P22455: TM-score 0.97, RMSD 0.78 Å
- 6J6Y chain D against the predicted model P22455: TM-score 0.97, RMSD 0.78 Å
- 6J6Y chain A against the predicted model P22455: TM-score 0.96, RMSD 0.89 Å
- 6J6Y chain A against the predicted model P22455: TM-score 0.96, RMSD 0.89 Å
- 5NWZ chain B against the predicted model P22455: TM-score 0.96, RMSD 1.35 Å
- 5NWZ chain B against the predicted model P22455: TM-score 0.96, RMSD 1.35 Å
- 4TYJ chain A against the predicted model P22455: TM-score 0.95, RMSD 1.45 Å
- 4TYJ chain A against the predicted model P22455: TM-score 0.95, RMSD 1.45 Å
- 5XFF chain A against the predicted model P22455: TM-score 0.95, RMSD 1.51 Å
- 5XFJ chain A against the predicted model P22455: TM-score 0.95, RMSD 1.49 Å
Elsewhere
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