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Ligand · FGF

FGF · N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide

FGF, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide (C25 H30 N8 O4, 506.6 g/mol), in the MolNFT structures on GenesisL1: bound…

Component
FGF
Formula
C25 H30 N8 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

FGF in 4 structures; the first of them:

  • 6JPJ · Crystal structure of FGF401 in complex of FGFR4 · FGF A800 · binds LEU473, GLY474, VAL481, ARG483, ALA484, THR499, VAL500, ALA501 and 9 more
  • 6YI8 · Human FGFR4 kinase domain (447-753) in complex with roblitinib · FGF A801 · binds LEU473, GLY474, VAL481, ARG483, ALA484, THR499, VAL500, ALA501 and 9 more
  • 6JPJ · Crystal structure of FGF401 in complex of FGFR4 · FGF A800 · binds LEU473, GLY474, VAL481, ARG483, ALA484, THR499, VAL500, ALA501 and 9 more
  • 6YI8 · Human FGFR4 kinase domain (447-753) in complex with roblitinib · FGF A801 · binds LEU473, GLY474, VAL481, ARG483, ALA484, THR499, VAL500, ALA501 and 9 more

Residues it binds most

ALA 6, VAL 6, GLY 6, LEU 6, GLU 6, ARG 6, CYS 6, ILE 6, LYS 6, THR 6 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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