UniProt P22336
Replication factor A protein 1 (P22336)
Replication factor A protein 1 (UniProt P22336): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22336
- Protein
- Replication factor A protein 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 15 · 3 records with a druggable one
Structures
13 records of P22336 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YNX | Solution structure of DNA binding domain A (DBD-A) of S.cerevisiae Replication Protein A (RPA) | solution nmr | A | — | — |
| 1YNX | Solution structure of DNA binding domain a (dbd-a) of S.CEREVISIAE replication protein a (rpa) | solution nmr | A | — | — |
| 5M1X | Crystal structure of S. cerevisiae Rfa1 N-OB domain mutant (K45E) | x-ray diffraction | A, B, C, D | — | 6 (best 0.73) |
| 5M1X | Crystal structure of S. cerevisiae RFA1 N-ob domain mutant (K45E) | x-ray diffraction | A, B, C, D | — | — |
| 5OMB | Crystal structure of K. lactis Ddc2 N-terminus in complex with S. cerevisiae Rfa1 N-OB domain | x-ray diffraction | A, B | CL | — |
| 5OMB | Crystal structure of K. lactis DDC2 N-terminus in complex with S. cerevisiae RFA1 N-ob domain | x-ray diffraction | A, B | CL | — |
| 5OMC | Crystal structure of K. lactis Ddc2 N-terminus in complex with S. cerevisiae Rfa1 (K45E mutant)… | x-ray diffraction | A, B | CL | — |
| 5OMC | Crystal structure of K. lactis DDC2 N-terminus in complex with S. cerevisiae RFA1 (K45E mutant)… | x-ray diffraction | A, B | CL | — |
| 6I52 | Yeast RPA bound to ssDNA | electron microscopy | C | — | — |
| 6I52 | Yeast rpa bound to ssdna | electron microscopy | C | — | — |
| 8B4J | Rfa1-N-terminal domain in complex with phosphorylated Ddc2 | x-ray diffraction | O | ZN | — |
| 8B4K | Rfa1-N-terminal domain in complex with phosphorylated Ddc2 | x-ray diffraction | A, B, C | — | 2 (best 0.59) |
| P22336 | AlphaFold monomer V2.0 prediction for replication factor a protein 1 (P22336) | predicted | A | — | 7 (best 0.70) |
Ligands
Experiment against prediction
- 8B4J chain O against the predicted model P22336: TM-score 0.99, RMSD 0.49 Å
- 5OMC chain A against the predicted model P22336: TM-score 0.98, RMSD 0.80 Å
- 5OMC chain A against the predicted model P22336: TM-score 0.98, RMSD 0.80 Å
- 8B4K chain A against the predicted model P22336: TM-score 0.98, RMSD 0.60 Å
- 5OMC chain B against the predicted model P22336: TM-score 0.98, RMSD 0.81 Å
- 5OMC chain B against the predicted model P22336: TM-score 0.98, RMSD 0.81 Å
- 8B4K chain B against the predicted model P22336: TM-score 0.98, RMSD 0.58 Å
- 5OMB chain A against the predicted model P22336: TM-score 0.97, RMSD 0.85 Å
- 5OMB chain A against the predicted model P22336: TM-score 0.97, RMSD 0.85 Å
- 8B4K chain C against the predicted model P22336: TM-score 0.97, RMSD 0.67 Å
Elsewhere
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