UniProt P20839
Inosine-5'-monophosphate dehydrogenase 1 (P20839)
Inosine-5'-monophosphate dehydrogenase 1 (UniProt P20839), EC 1.1.1.205: 20 experimental structures on GenesisL1, 4 ligands bound, 160 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P20839
- Protein
- Inosine-5'-monophosphate dehydrogenase 1
- EC
- 1.1.1.205
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 160 · 8 records with a druggable one
Structures
20 records of P20839 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JCN | Binary complex of human type-I inosine monophosphate dehydrogenase with 6-cl-imp | x-ray diffraction | A, B | — | — |
| 1JCN | Binary complex of human type-I inosine monophosphate dehydrogenase with 6-cl-imp | x-ray diffraction | A, B | — | — |
| 7RER | Human IMPDH1 treated with ATP, imp, and NAD+ | electron microscopy | A, D, C, B, E, H, G, F | NAD, IMP | 20 (best 0.80) |
| 7RER | Human IMPDH1 treated with ATP, imp, and NAD+ | electron microscopy | A, D, C, B, E, H, G, F | NAD, IMP | — |
| 7RES | Human IMPDH1 treated with ATP, imp, and NAD+, octamer-centered | electron microscopy | A, B, C, D, E, F, G, H | ATP, IMP, NAD | — |
| 7RFE | Human IMPDH1 treated with GTP, imp, and NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP | 20 (best 0.78) |
| 7RFE | Human IMPDH1 treated with GTP, imp, and NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP | — |
| 7RFG | Human IMPDH1 treated with GTP, imp, and NAD+ octamer-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP | 20 (best 0.79) |
| 7RFG | Human IMPDH1 treated with GTP, imp, and NAD+ octamer-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP | — |
| 7RGI | Human retinal variant IMPDH1(546) treated with GTP, ATP, imp, NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | NAD, IMP | — |
| 7RGI | Human retinal variant IMPDH1(546) treated with GTP, ATP, imp, NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | NAD, IMP | — |
| 7RGL | Human retinal variant IMPDH1(546) treated with ATP, imp, NAD+, interface-centered | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | — |
| 7RGM | Human retinal variant IMPDH1(546) treated with ATP, imp, NAD+, octamer-centered | electron microscopy | A, B, C, D, E, F, G, H | ATP, IMP, NAD | — |
| 7RGQ | Human retinal variant IMPDH1(546) treated with GTP, ATP, imp, NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, NAD, IMP, ATP | 20 (best 0.84) |
| 7RGQ | Human retinal variant IMPDH1(546) treated with GTP, ATP, imp, NAD+; interface-centered | electron microscopy | A, B, C, D, E, F, G, H | GTP, NAD, IMP, ATP | — |
| 8U7M | Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+ | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP, NAD | 20 (best 0.79) |
| 8U7Q | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+… | electron microscopy | A, B, C, D, E, F, G, H | GTP, NAD, IMP, ATP | 20 (best 0.77) |
| 8U7V | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+… | electron microscopy | A, B, C, D, E, F, G, H | GTP, NAD, IMP, ATP | 20 (best 0.81) |
| 8U8Y | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+… | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | 20 (best 0.78) |
| P20839 | AlphaFold monomer V2.0 prediction for inosine-5'-monophosphate dehydrogenase 1 (P20839) | — | — | — |
Ligands
Elsewhere
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