UniProt P20815
Cytochrome P450 3A5 (P20815)
Cytochrome P450 3A5 (UniProt P20815), EC 1.14.14.1: 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20815
- Protein
- Cytochrome P450 3A5
- EC
- 1.14.14.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 46 · 3 records with a druggable one
Structures
9 records of P20815 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VEU | Human cytochrome P450 3A5 (CYP3A5) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | HEM, RIT | — |
| 6MJM | Substrate Free Cytochrome P450 3A5 (CYP3A5) | x-ray diffraction | A | HEM | — |
| 6MJM | Substrate free cytochrome P450 3A5 (CYP3A5) | x-ray diffraction | A | HEM | — |
| 7LAD | Clobetasol propionate bound to CYP3A5 | x-ray diffraction | A | HEM, XRD | 6 (best 0.88) |
| 7LAD | Clobetasol propionate bound to CYP3A5 | x-ray diffraction | A | HEM, XRD | — |
| 7SV2 | Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin | x-ray diffraction | A, B, C, D | HEM, MWY | 20 (best 0.85) |
| 7SV2 | Human cytochrome P450 (cyp) 3A5 ternary complex with azamulin | x-ray diffraction | A, B, C, D | HEM, MWY | — |
| 8SG5 | Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole | x-ray diffraction | A, B, C, D, E, F, G, H | HEM, CL6, CE9 | 20 (best 0.86) |
| P20815 | AlphaFold monomer V2.0 prediction for cytochrome P450 3A5 (P20815) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 8 records
- MWY · (3as,4r,5s,6r,8r,9r,9ar,10r)-6-ethyl-5-hydroxy-4,6,9, 10-tetramethyl-1-oxodecahydro-3A,9-propanocyclopenta[8]annulen-8-yl [(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetate · in 2 records
- XRD · Clobetasol propionate · in 2 records
- CE9 · Dodecyl nona ethylene glycol ether · in 1 record
- CL6 · 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole · in 1 record
- RIT · Ritonavir · in 1 record
Experiment against prediction
- 5VEU chain K against the predicted model P20815: TM-score 1.00, RMSD 0.55 Å
- 5VEU chain G against the predicted model P20815: TM-score 0.99, RMSD 0.57 Å
- 5VEU chain C against the predicted model P20815: TM-score 0.99, RMSD 0.62 Å
- 5VEU chain I against the predicted model P20815: TM-score 0.99, RMSD 0.64 Å
- 5VEU chain L against the predicted model P20815: TM-score 0.99, RMSD 0.61 Å
- 5VEU chain J against the predicted model P20815: TM-score 0.99, RMSD 0.66 Å
- 5VEU chain E against the predicted model P20815: TM-score 0.99, RMSD 0.64 Å
- 5VEU chain D against the predicted model P20815: TM-score 0.99, RMSD 0.68 Å
- 5VEU chain B against the predicted model P20815: TM-score 0.99, RMSD 0.69 Å
- 5VEU chain H against the predicted model P20815: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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