UniProt P20701
Chimera protein of Integrin beta-3 and Integrin alpha-L (P20701)
Chimera protein of Integrin beta-3 and Integrin alpha-L (UniProt P20701): 80 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P20701
- Protein
- Chimera protein of Integrin beta-3 and Integrin alpha-L
- Experimental structures
- 80
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 33 · 5 records with a druggable one
Structures
81 records of P20701 in the MolNFT archive: 80 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CQP | Crystal structure analysis of the complex lfa-1 (CD11A) I-domain / lovastatin at 2.6 a resolution | x-ray diffraction | A, B | — | — |
| 1CQP | Crystal structure analysis of the complex lfa-1 (CD11A) I-domain / lovastatin at 2.6 a resolution | x-ray diffraction | A, B | — | — |
| 1DGQ | NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 | solution nmr | A | — | — |
| 1DGQ | NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 | solution nmr | A | — | — |
| 1LFA | CD11A I-domain with bound mn++ | x-ray diffraction | A, B | — | — |
| 1LFA | CD11A I-domain with bound mn++ | x-ray diffraction | A, B | — | — |
| 1MJN | Crystal Structure of the intermediate affinity aL I domain mutant | x-ray diffraction | A | — | — |
| 1MJN | Crystal structure of the intermediate affinity al I domain mutant | x-ray diffraction | A | — | — |
| 1MQ8 | Crystal structure of alphaL I domain in complex with ICAM-1 | x-ray diffraction | B, D | — | — |
| 1MQ8 | Crystal structure of alphal I domain in complex with icam-1 | x-ray diffraction | B, D | — | — |
| 1MQ9 | Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact | x-ray diffraction | A | — | — |
| 1MQ9 | Crystal structure of high affinity alphal I domain with ligand mimetic crystal contact | x-ray diffraction | A | — | — |
| 1MQA | Crystal structure of high affinity alphaL I domain in the absence of ligand or metal | x-ray diffraction | A | — | — |
| 1MQA | Crystal structure of high affinity alphal I domain in the absence of ligand or metal | x-ray diffraction | A | — | — |
| 1RD4 | An allosteric inhibitor of LFA-1 bound to its I-domain | x-ray diffraction | A, B, C, D | — | — |
| 1RD4 | An allosteric inhibitor of lfa-1 bound to its I-domain | x-ray diffraction | A, B, C, D | — | — |
| 1T0P | Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of… | x-ray diffraction | A | — | — |
| 1T0P | Structural basis of icam recognition by integrin ALPAHLBETA2 revealed in the complex structure of… | x-ray diffraction | A | — | — |
| 1XDD | X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution | x-ray diffraction | A, B | — | — |
| 1XDD | X-ray structure of lfa-1 I-domain in complex with LFA703 at 2.2A resolution | x-ray diffraction | A, B | — | — |
| 1XDG | X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution | x-ray diffraction | A, B | — | — |
| 1XDG | X-ray structure of lfa-1 I-domain in complex with LFA878 at 2.1A resolution | x-ray diffraction | A, B | — | — |
| 1XUO | X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution | x-ray diffraction | A, B | — | — |
| 1XUO | X-ray structure of lfa-1 I-domain bound to a 1,4-diazepane- 2,5-dione inhibitor at 1.8A resolution | x-ray diffraction | A, B | — | — |
| 1ZON | CD11A I-domain without bound cation | x-ray diffraction | A | — | — |
| 1ZON | CD11A I-domain without bound cation | x-ray diffraction | A | — | — |
| 1ZOO | CD11A I-domain with bound magnesium ion | x-ray diffraction | A, B | — | — |
| 1ZOO | CD11A I-domain with bound magnesium ion | x-ray diffraction | A, B | — | — |
| 1ZOP | CD11A I-domain with bound magnesium ion | x-ray diffraction | A, B | — | — |
| 1ZOP | CD11A I-domain with bound magnesium ion | x-ray diffraction | A, B | — | — |
| 2ICA | CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S… | x-ray diffraction | A | — | — |
| 2ICA | CD11A (LFA1) I-domain complexed with bms-587101 aka 5-[(5S, 9R)-9-(4… | x-ray diffraction | A | — | — |
| 2K8O | Solution structure of integrin Alpha L | solution nmr | A | — | — |
| 2K8O | Solution structure of integrin alpha L | solution nmr | A | — | — |
| 2M3E | The Integrin Alpha L Transmembrane Domain in Bicelles: Structure and Interaction with Integrin Beta… | solution nmr | A | — | — |
| 2M3E | The integrin alpha L transmembrane domain in bicelles: structure and interaction with integrin beta… | solution nmr | A | — | — |
| 2O7N | CD11A (LFA1) I-domain complexed with 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7… | x-ray diffraction | A | — | — |
| 2O7N | CD11A (LFA1) I-domain complexed with 7A-[(4-CYANOPHENYL)METHYL]-6-(3… | x-ray diffraction | A | — | — |
| 3BN3 | crystal structure of ICAM-5 in complex with aL I domain | x-ray diffraction | A | — | — |
| 3BN3 | Crystal structure of icam-5 in complex with al I domain | x-ray diffraction | A | — | — |
| 3BQM | LFA-1 I domain bound to inhibitors | x-ray diffraction | B, C | — | — |
| 3BQM | Lfa-1 I domain bound to inhibitors | x-ray diffraction | B, C | — | — |
| 3BQN | LFA-1 I domain bound to inhibitors | x-ray diffraction | B, C | — | — |
| 3BQN | Lfa-1 I domain bound to inhibitors | x-ray diffraction | B, C | — | — |
| 3E2M | LFA-1 I domain bound to inhibitors | x-ray diffraction | A, B | — | — |
| 3E2M | Lfa-1 I domain bound to inhibitors | x-ray diffraction | A, B | — | — |
| 3EOA | Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I | x-ray diffraction | I, J | — | — |
| 3EOA | Crystal structure the Fab fragment of efalizumab in complex with lfa-1 I domain, form I | x-ray diffraction | I, J | — | — |
| 3EOB | Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II | x-ray diffraction | I, J | — | — |
| 3EOB | Crystal structure the Fab fragment of efalizumab in complex with lfa-1 I domain, form II | x-ray diffraction | I, J | — | — |
| 3F74 | Crystal structure of wild type LFA1 I domain | x-ray diffraction | A, B, C | — | — |
| 3F74 | Crystal structure of wild type LFA1 I domain | x-ray diffraction | A, B, C | — | — |
| 3F78 | Crystal structure of wild type LFA1 I domain complexed with isoflurane | x-ray diffraction | A, B, C | — | — |
| 3F78 | Crystal structure of wild type LFA1 I domain complexed with isoflurane | x-ray diffraction | A, B, C | — | — |
| 3HI6 | Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its… | x-ray diffraction | A, B | — | — |
| 3HI6 | Crystal structure of intermediate affinity I domain of integrin lfa-1 with the Fab fragment of its… | x-ray diffraction | A, B | — | — |
| 3M6F | CD11A I-domain complexed with 6-((5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO… | x-ray diffraction | A | — | — |
| 3M6F | CD11A I-domain complexed with 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5… | x-ray diffraction | A | — | — |
| 3TCX | Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native… | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X, Z, b | — | — |
| 3TCX | Structure of engineered single domain icam-1 D1 with high-affinity al integrin I domain of native… | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X, Z, b | — | — |
21 records more on the page itself.
Ligands
- MG · Magnesium ion · in 15 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- CA · Calcium ion · in 8 records
- BJZ · 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid · in 2 records
- 803 · Lovastatin · in 1 record
- CL · Chloride ion · in 1 record
Experiment against prediction
- 5E6S chain C against the predicted model P20701: TM-score 1.00, RMSD 0.49 Å
- 5E6S chain C against the predicted model P20701: TM-score 1.00, RMSD 0.49 Å
- 5E6S chain E against the predicted model P20701: TM-score 1.00, RMSD 0.51 Å
- 5E6S chain E against the predicted model P20701: TM-score 1.00, RMSD 0.51 Å
- 5E6R chain A against the predicted model P20701: TM-score 0.99, RMSD 0.73 Å
- 1XUO chain B against the predicted model P20701: TM-score 0.99, RMSD 0.42 Å
- 1XUO chain B against the predicted model P20701: TM-score 0.99, RMSD 0.42 Å
- 5E6S chain A against the predicted model P20701: TM-score 0.99, RMSD 0.76 Å
- 5E6S chain A against the predicted model P20701: TM-score 0.99, RMSD 0.76 Å
- 5E6U chain A against the predicted model P20701: TM-score 0.99, RMSD 0.82 Å
Elsewhere
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