MolNFT v1 · #14750 · protein

Crystal structure of the intermediate affinity al I domain mutant

1MJN · Integrin alpha-L: “Crystal structure of the intermediate affinity al I domain mutant”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.37). MolNFT v1 #14750 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1MJN
Type: protein
Length: 179 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin alpha-L
UniProt: P20701
Ligands: MG
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin alpha-L	protein	179	41% helix, 23% strand	P20701

Ligands and binding sites

MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.37	0.79	13	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1MJN · Crystal Structure of the intermediate affinity aL I domain mutant · the same entry in another collection · chain A against A, TM-score 1.00
P20701 · AlphaFold monomer V2.0 prediction for integrin alpha-L (P20701) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20701
Elsewhere: RCSB PDB 1MJN · PDBe 1MJN · UniProt P20701

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