MolNFT v1 · #46544 · protein
CD11A (LFA1) I-domain complexed with 7A-[(4-CYANOPHENYL)METHYL]-6-(3, 5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-PYRROLO[1,2-A]PYRROLE- 7-carbonitrile
2O7N · Integrin alpha-L: “CD11A (LFA1) I-domain complexed with 7A-[(4-CYANOPHENYL)METHYL]-6-(3…”. X-ray diffraction, 1 ligand (2O7), 1 pocket (best druggability 0.67). MolNFT v1 #46544 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2O7N
- Type
- protein
- Length
- 180 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin alpha-L
- UniProt
- P20701
- Ligands
- 2O7
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin alpha-L | protein | 180 | 39% helix, 22% strand | P20701 |
Ligands and binding sites
- 2O7 · 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.67 | 0.84 | 23 | 2O7 |
Compared structures
- 2O7N · CD11A (LFA1) I-domain complexed with 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-o… · the same entry in another collection · chain A against A, TM-score 1.00
- P20701 · AlphaFold monomer V2.0 prediction for integrin alpha-L (P20701) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20701
- Elsewhere: RCSB PDB 2O7N · PDBe 2O7N · UniProt P20701
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.