UniProt P16184
P16184
P16184 (UniProt P16184): 50 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P16184
- Experimental structures
- 50
- Predicted models
- 1
Structures
51 records of P16184 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 1CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 1DAJ | Comparison of ternary complexes of pneumocystis carinii and wild type human dihydrofolate reductase… | x-ray diffraction | A | — | — |
| 1DAJ | Comparison of ternary complexes of pneumocystis carinii and wild type human dihydrofolate reductase… | x-ray diffraction | A | — | — |
| 1DYR | The structure of pneumocystis carinii dihydrofolate reductase to 1.9 ångströms resolution | x-ray diffraction | A | — | — |
| 1DYR | The structure of pneumocystis carinii dihydrofolate reductase to 1.9 ångströms resolution | x-ray diffraction | A | — | — |
| 1E26 | Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase… | x-ray diffraction | A | — | — |
| 1E26 | Design, synthesis and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase… | x-ray diffraction | A | — | — |
| 1KLK | Crystal structure of pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and… | x-ray diffraction | A | — | — |
| 1KLK | Crystal structure of pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and… | x-ray diffraction | A | — | — |
| 1LY3 | Analysis of quinazoline and pyridopyrimidine N9-C10 reversed bridge antifolates in complex with… | x-ray diffraction | A | — | — |
| 1LY3 | Analysis of quinazoline and pyridopyrimidine N9-C10 reversed bridge antifolates in complex with… | x-ray diffraction | A | — | — |
| 1LY4 | Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex… | x-ray diffraction | A | — | — |
| 1LY4 | Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex… | x-ray diffraction | A | — | — |
| 1S3Y | Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis… | x-ray diffraction | A | — | — |
| 1S3Y | Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis… | x-ray diffraction | A | — | — |
| 1VJ3 | Structural studies on bio-active compounds. crystal structure and molecular modeling studies on the… | x-ray diffraction | A | — | — |
| 1VJ3 | Structural studies on bio-active compounds. crystal structure and molecular modeling studies on the… | x-ray diffraction | A | — | — |
| 2CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 2CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 2FZH | New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse… | x-ray diffraction | A | — | — |
| 2FZH | New insights into dihydrofolate reductase interactions: analysis of pneumocystis carinii and mouse… | x-ray diffraction | A | — | — |
| 2FZI | New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with… | x-ray diffraction | A | — | — |
| 2FZI | New insights into DHFR interactions: analysis of pneumocystis carinii and mouse DHFR complexes with… | x-ray diffraction | A | — | — |
| 3CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 3CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 3NZ6 | Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of… | x-ray diffraction | X | — | — |
| 3NZ6 | Structural analysis of pneumocystis carinii and human DHFR complexes with NADPH and a series of… | x-ray diffraction | X | — | — |
| 3NZ9 | Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of… | x-ray diffraction | X | — | — |
| 3NZ9 | Structural analysis of pneumocystis carinii and human DHFR complexes with NADPH and a series of… | x-ray diffraction | X | — | — |
| 3NZA | Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of… | x-ray diffraction | X | — | — |
| 3NZA | Structural analysis of pneumocystis carinii and human DHFR complexes with NADPH and a series of… | x-ray diffraction | X | — | — |
| 3NZB | Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of… | x-ray diffraction | X | — | — |
| 3NZB | Structural analysis of pneumocystis carinii and human DHFR complexes with NADPH and a series of… | x-ray diffraction | X | — | — |
| 3NZC | Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of… | x-ray diffraction | X | — | — |
| 3NZC | Structural analysis of pneumocystis carinii and human DHFR complexes with NADPH and a series of… | x-ray diffraction | X | — | — |
| 3TD8 | Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and… | x-ray diffraction | A | — | — |
| 3TD8 | Structural analysis of pneumocystis carinii dihydrofolate reductase complex with NADPH and… | x-ray diffraction | A | — | — |
| 4CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 4CD2 | Ligand induced conformational changes in the crystal structures of pneumocystis carinii… | x-ray diffraction | A | — | — |
| 4G8Z | pcDHFR K37S/F69N double mutant TMP NADPH ternary complex | x-ray diffraction | X | — | — |
| 4G8Z | Pcdhfr K37S/F69N double mutant tmp NADPH ternary complex | x-ray diffraction | X | — | — |
| 4IXE | pcDHFR-NADPH-270 | x-ray diffraction | D | — | — |
| 4IXE | Pcdhfr-NADPH-270 | x-ray diffraction | D | — | — |
| 4IXF | pcDHFR-269 F69N variant | x-ray diffraction | X | — | — |
| 4IXF | Pcdhfr-269 F69N variant | x-ray diffraction | X | — | — |
| 4IXG | pcDHFR-268-K37S-N69F variant | x-ray diffraction | X | — | — |
| 4IXG | Pcdhfr-268-K37S-N69F variant | x-ray diffraction | X | — | — |
| 4QJZ | Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24… | x-ray diffraction | D | — | — |
| 4QJZ | Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24… | x-ray diffraction | D | — | — |
| P16184 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P16184) | predicted | A | — | — |
Experiment against prediction
- 3TD8 chain A against the predicted model P16184: TM-score 0.98, RMSD 1.03 Å
- 3TD8 chain A against the predicted model P16184: TM-score 0.98, RMSD 1.03 Å
- 4CD2 chain A against the predicted model P16184: TM-score 0.97, RMSD 0.96 Å
- 4CD2 chain A against the predicted model P16184: TM-score 0.97, RMSD 0.96 Å
- 4QJZ chain D against the predicted model P16184: TM-score 0.97, RMSD 1.30 Å
- 4QJZ chain D against the predicted model P16184: TM-score 0.97, RMSD 1.30 Å
- 1DYR chain A against the predicted model P16184: TM-score 0.97, RMSD 1.33 Å
- 1DYR chain A against the predicted model P16184: TM-score 0.97, RMSD 1.33 Å
- 4G8Z chain X against the predicted model P16184: TM-score 0.97, RMSD 1.21 Å
- 4G8Z chain X against the predicted model P16184: TM-score 0.97, RMSD 1.21 Å
Elsewhere
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