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Ligand · MOT

MOT · N-[4-[(2,4-diaminofuro[2,3d]pyrimidin-5-yl)methyl]methylamino]-benzoyl]-L-glutamate

MOT, N-[4-[(2,4-diaminofuro[2,3d]pyrimidin-5-yl)methyl]methylamino]-benzoyl]-L-glutamate (C20 H22 N6 O6, 442.4 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within…

Component
MOT
Formula
C20 H22 N6 O6
Class
ligand
Structures
8
PDB entries
4

Binding sites

MOT in 8 structures; the first of them:

  • 1DAJ · Comparison of ternary complexes of pneumocystis carinii and wild type human dihydrofolate… · MOT A208 · binds ILE10, VAL11, ALA12, LEU25, GLU32, ILE33, PHE36, LYS37 and 10 more
  • 1HFP · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, ARG28, GLU30, GLY31, ARG32 and 11 more
  • 1HFQ · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, GLU30, SER31, ARG32, PHE34 and 10 more
  • 1HFR · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, GLN35 and 9 more
  • 1DAJ · Comparison of ternary complexes of pneumocystis carinii and wild type human dihydrofolate… · MOT A208 · binds ILE10, VAL11, ALA12, LEU25, GLU32, ILE33, PHE36, LYS37 and 10 more
  • 1HFP · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, ARG28, GLU30, GLY31, ARG32 and 11 more
  • 1HFQ · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, GLU30, SER31, ARG32, PHE34 and 10 more
  • 1HFR · Comparison of ternary crystal complexes of human dihydrofolate reductase with NADPH and a… · MOT A188 · binds ILE7, VAL8, ALA9, LEU22, GLU30, PHE31, PHE34, GLN35 and 9 more

Residues it binds most

ILE 8, LEU 8, ARG 8, VAL 8, PHE 8, SER 8, THR 8, ALA 8, GLU 8, PRO 8 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate

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