UniProt P14925
Peptidyl-glycine alpha-amidating monooxygenase (P14925)
Peptidyl-glycine alpha-amidating monooxygenase (UniProt P14925), EC 1.14.17.3, 4.3.2.5: 64 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 37 pockets. Binding sites, druggability and experiment…
- UniProt
- P14925
- Protein
- Peptidyl-glycine alpha-amidating monooxygenase
- EC
- 1.14.17.3, 4.3.2.5
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 37 · 9 records with a druggable one
Structures
65 records of P14925 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OPM | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound substrate | x-ray diffraction | A | — | — |
| 1OPM | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound substrate | x-ray diffraction | A | — | — |
| 1PHM | Peptidylglycine alpha-hydroxylating monooxygenase (phm) from rat | x-ray diffraction | A | — | — |
| 1PHM | Peptidylglycine alpha-hydroxylating monooxygenase (phm) from rat | x-ray diffraction | A | — | — |
| 1SDW | Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen | x-ray diffraction | A | — | — |
| 1SDW | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen | x-ray diffraction | A | — | — |
| 1YI9 | Crystal Structure Analysis of the oxidized form of the M314I mutant of Peptidylglycine… | x-ray diffraction | A | — | — |
| 1YI9 | Crystal structure analysis of the oxidized form of the M314I mutant of peptidylglycine… | x-ray diffraction | A | — | — |
| 1YIP | Oxidized Peptidylglycine Alpha-Hydroxylating Monooxygenase (PHM) in a New Crystal Form | x-ray diffraction | A | — | — |
| 1YIP | Oxidized peptidylglycine alpha-hydroxylating monooxygenase (phm) in a new crystal form | x-ray diffraction | A | — | — |
| 1YJK | Reduced Peptidylglycine Alpha-Hydroxylating Monooxygenase (PHM) in a New Crystal Form | x-ray diffraction | A | — | — |
| 1YJK | Reduced peptidylglycine alpha-hydroxylating monooxygenase (phm) in a new crystal form | x-ray diffraction | A | — | — |
| 1YJL | Reduced Peptidylglycine alpha-Hydroxylating Monooxygenase in a new crystal form | x-ray diffraction | A | — | — |
| 1YJL | Reduced peptidylglycine alpha-hydroxylating monooxygenase in a new crystal form | x-ray diffraction | A | — | — |
| 3FVZ | Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) | x-ray diffraction | A | — | — |
| 3FVZ | Structure of peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) | x-ray diffraction | A | — | — |
| 3FW0 | Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) bound to… | x-ray diffraction | A | — | — |
| 3FW0 | Structure of peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) bound to… | x-ray diffraction | A | — | — |
| 3MIB | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite | x-ray diffraction | A | — | — |
| 3MIB | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound nitrite | x-ray diffraction | A | — | — |
| 3MIC | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MIC | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MID | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MID | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MIE | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MIE | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide obtained… | x-ray diffraction | A | — | — |
| 3MIF | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound carbon monooxide… | x-ray diffraction | A | — | — |
| 3MIF | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound carbon monooxide… | x-ray diffraction | A | — | — |
| 3MIG | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite… | x-ray diffraction | A | — | — |
| 3MIG | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound nitrite… | x-ray diffraction | A | — | — |
| 3MIH | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide, obtained… | x-ray diffraction | A | — | — |
| 3MIH | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide, obtained… | x-ray diffraction | A | — | — |
| 3MLJ | Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound carbon monooxide… | x-ray diffraction | A | — | — |
| 3MLJ | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound carbon monooxide… | x-ray diffraction | A | — | — |
| 3MLK | Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite | x-ray diffraction | A | — | — |
| 3MLK | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound nitrite | x-ray diffraction | A | — | — |
| 3MLL | Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide | x-ray diffraction | A | — | — |
| 3MLL | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide | x-ray diffraction | A | — | — |
| 3PHM | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase (phm) | x-ray diffraction | A | — | — |
| 3PHM | Reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase (phm) | x-ray diffraction | A | — | — |
| 4E4Z | Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) in complex with hydrogen… | x-ray diffraction | A | — | — |
| 4E4Z | Oxidized (CU2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) in complex with hydrogen… | x-ray diffraction | A | — | — |
| 5WJA | Crystal structure of H107A peptidylglycine alpha-hydroxylating monooxygenase (PHM) in complex with… | x-ray diffraction | A, D | CU, NI | 6 (best 0.77) |
| 5WJA | Crystal structure of H107A peptidylglycine alpha-hydroxylating monooxygenase (phm) in complex with… | x-ray diffraction | A, D | CU, NI | — |
| 5WKW | Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) | x-ray diffraction | A | — | — |
| 5WKW | Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (phm) | x-ray diffraction | A | — | — |
| 5WM0 | Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked… | x-ray diffraction | A | — | — |
| 5WM0 | Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (phm) soaked… | x-ray diffraction | A | — | — |
| 6ALA | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) in complex with… | x-ray diffraction | A, C | CU | — |
| 6ALA | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (phm) in complex with… | x-ray diffraction | A, C | CU | — |
| 6ALV | Crystal structure of H107A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant (no CuH… | x-ray diffraction | A | CU, AZI | 5 (best 0.61) |
| 6ALV | Crystal structure of H107A-peptidylglycine alpha-hydroxylating monooxygenase (phm) mutant (no cuh… | x-ray diffraction | A | CU, AZI | — |
| 6AMP | Crystal structure of H172A PHM (CuH absent, CuM present) | x-ray diffraction | A | CU | 2 (best 0.52) |
| 6AMP | Crystal structure of H172A phm (cuh absent, cum present) | x-ray diffraction | A | CU | — |
| 6AN3 | Crystal structure of H172A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant soaked… | x-ray diffraction | A | CU | 4 (best 0.51) |
| 6AN3 | Crystal structure of H172A-peptidylglycine alpha-hydroxylating monooxygenase (phm) mutant soaked… | x-ray diffraction | A | CU | — |
| 6AO6 | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) | x-ray diffraction | A | CU, NI | 3 (best 0.64) |
| 6AO6 | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (phm) | x-ray diffraction | A | CU, NI | — |
| 6AY0 | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with… | x-ray diffraction | A | CU | 2 (best 0.64) |
| 6AY0 | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (phm) soaked with… | x-ray diffraction | A | CU | — |
5 records more on the page itself.
Ligands
Experiment against prediction
- 3PHM chain A against the predicted model P14925: TM-score 0.99, RMSD 0.54 Å
- 3PHM chain A against the predicted model P14925: TM-score 0.99, RMSD 0.54 Å
- 3MLJ chain A against the predicted model P14925: TM-score 0.99, RMSD 0.55 Å
- 3MLJ chain A against the predicted model P14925: TM-score 0.99, RMSD 0.55 Å
- 6AO6 chain A against the predicted model P14925: TM-score 0.99, RMSD 0.62 Å
- 6AO6 chain A against the predicted model P14925: TM-score 0.99, RMSD 0.62 Å
- 3MLL chain A against the predicted model P14925: TM-score 0.99, RMSD 0.62 Å
- 3MLL chain A against the predicted model P14925: TM-score 0.99, RMSD 0.62 Å
- 1PHM chain A against the predicted model P14925: TM-score 0.99, RMSD 0.66 Å
- 1PHM chain A against the predicted model P14925: TM-score 0.99, RMSD 0.66 Å
Elsewhere
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