UniProt P14489
Beta-lactamase OXA-10 (P14489)
Beta-lactamase OXA-10 (UniProt P14489), EC 3.5.2.6: 67 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14489
- Protein
- Beta-lactamase OXA-10
- EC
- 3.5.2.6
- Experimental structures
- 67
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 5 · 1 record with a druggable one
Structures
68 records of P14489 in the MolNFT archive: 67 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E3U | MAD structure of OXA10 class D beta-lactamase | x-ray diffraction | A, B, C, D | — | — |
| 1E3U | Mad structure of OXA10 class D beta-lactamase | x-ray diffraction | A, B, C, D | — | — |
| 1E4D | Structure of OXA10 beta-lactamase at pH 8.3 | x-ray diffraction | A, B, C, D | — | — |
| 1E4D | Structure of OXA10 beta-lactamase at pH 8.3 | x-ray diffraction | A, B, C, D | — | — |
| 1EWZ | Crystal structure of the oxa-10 beta-lactamase from pseudomonas aeruginosa | x-ray diffraction | A, B, C, D | — | — |
| 1EWZ | Crystal structure of the oxa-10 beta-lactamase from pseudomonas aeruginosa | x-ray diffraction | A, B, C, D | — | — |
| 1FOF | Crystal structure of the class D beta-lactamase oxa-10 | x-ray diffraction | A, B | — | — |
| 1FOF | Crystal structure of the class D beta-lactamase oxa-10 | x-ray diffraction | A, B | — | — |
| 1K4E | Crystal structure of the class D beta-lactamases oxa-10 determined by mad phasing with… | x-ray diffraction | A, B | — | — |
| 1K4E | Crystal structure of the class D beta-lactamases oxa-10 determined by mad phasing with… | x-ray diffraction | A, B | — | — |
| 1K4F | Crystal structure of the class D beta-lactamase oxa-10 at 1.6 a resolution | x-ray diffraction | A, B | — | — |
| 1K4F | Crystal structure of the class D beta-lactamase oxa-10 at 1.6 a resolution | x-ray diffraction | A, B | — | — |
| 1K54 | OXA-10 class D beta-lactamase partially acylated with reacted 6beta-(1-hydroxy-1-methylethyl)… | x-ray diffraction | A, B, C, D | — | — |
| 1K54 | Oxa-10 class D beta-lactamase partially acylated with reacted 6BETA- (1-hydroxy-1-methylethyl)… | x-ray diffraction | A, B, C, D | — | — |
| 1K55 | OXA 10 class D beta-lactamase at pH 7.5 | x-ray diffraction | A, B, C, D | — | — |
| 1K55 | Oxa 10 class D beta-lactamase at pH 7.5 | x-ray diffraction | A, B, C, D | — | — |
| 1K56 | OXA 10 class D beta-lactamase at pH 6.5 | x-ray diffraction | A, B, C, D | — | — |
| 1K56 | Oxa 10 class D beta-lactamase at pH 6.5 | x-ray diffraction | A, B, C, D | — | — |
| 1K57 | OXA 10 class D beta-lactamase at pH 6.0 | x-ray diffraction | A, B, C, D | — | — |
| 1K57 | Oxa 10 class D beta-lactamase at pH 6.0 | x-ray diffraction | A, B, C, D | — | — |
| 1K6R | Structure of the class D beta-lactamase oxa-10 in complex with moxalactam | x-ray diffraction | A, B | — | — |
| 1K6R | Structure of the class D beta-lactamase oxa-10 in complex with moxalactam | x-ray diffraction | A, B | — | — |
| 1K6S | Structure of the class D beta-lactamase oxa-10 in complex with a phenylboronic acid | x-ray diffraction | A, B | — | — |
| 1K6S | Structure of the class D beta-lactamase oxa-10 in complex with a phenylboronic acid | x-ray diffraction | A, B | — | — |
| 2HP5 | Crystal Structure of the OXA-10 W154G mutant at pH 7.0 | x-ray diffraction | A, B, C, D | — | — |
| 2HP5 | Crystal structure of the oxa-10 W154G mutant at pH 7.0 | x-ray diffraction | A, B, C, D | — | — |
| 2HP6 | Crystal structure of the OXA-10 W154A mutant at pH 7.5 | x-ray diffraction | A, B | — | — |
| 2HP6 | Crystal structure of the oxa-10 W154A mutant at pH 7.5 | x-ray diffraction | A, B | — | — |
| 2HP9 | Crystal Structure of the OXA-10 W154A mutant at pH 6.0 | x-ray diffraction | A, B | — | — |
| 2HP9 | Crystal structure of the oxa-10 W154A mutant at pH 6.0 | x-ray diffraction | A, B | — | — |
| 2HPB | Crystal structure of the OXA-10 W154A mutant at pH 9.0 | x-ray diffraction | A, B | — | — |
| 2HPB | Crystal structure of the oxa-10 W154A mutant at pH 9.0 | x-ray diffraction | A, B | — | — |
| 2RL3 | Crystal structure of the OXA-10 W154H mutant at pH 7 | x-ray diffraction | A, B | — | — |
| 2RL3 | Crystal structure of the oxa-10 W154H mutant at pH 7 | x-ray diffraction | A, B | — | — |
| 2WGI | Crystal structure of the acyl-enzyme OXA-10 W154A-benzylpenicillin at pH 6 | x-ray diffraction | A, B | — | — |
| 2WGI | Crystal structure of the acyl-enzyme oxa-10 W154A- benzylpenicillin at pH 6 | x-ray diffraction | A, B | — | — |
| 2WGV | Crystal structure of the OXA-10 V117T mutant at pH 6.5 inhibited by a chloride ion | x-ray diffraction | A, B | — | — |
| 2WGV | Crystal structure of the oxa-10 V117T mutant at pH 6.5 inhibited by a chloride ion | x-ray diffraction | A, B | — | — |
| 2WGW | Crystal structure of the OXA-10 V117T mutant at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2WGW | Crystal structure of the oxa-10 V117T mutant at pH 8.0 | x-ray diffraction | A, B | — | — |
| 2WKH | Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7 | x-ray diffraction | A, B | — | — |
| 2WKH | Crystal structure of the acyl-enzyme oxa-10 K70C-ampicillin at pH 7 | x-ray diffraction | A, B | — | — |
| 2WKI | Crystal structure of the OXA-10 K70C mutant at pH 7.0 | x-ray diffraction | A, B | — | — |
| 2WKI | Crystal structure of the oxa-10 K70C mutant at pH 7.0 | x-ray diffraction | A, B | — | — |
| 2X01 | Crystal structure of the oxa-10 S67A mutant at pH 7 | x-ray diffraction | A, B | — | — |
| 2X01 | Crystal structure of the oxa-10 S67A mutant at pH 7 | x-ray diffraction | A, B | — | — |
| 2X02 | Crystal structure of the class D beta-lactamase oxa-10 at 1.35 a resolution | x-ray diffraction | A, B | — | — |
| 2X02 | Crystal structure of the class D beta-lactamase oxa-10 at 1.35 a resolution | x-ray diffraction | A, B | — | — |
| 3LCE | Crystal Structure of Oxa-10 Beta-Lactamase Covalently Bound to Cyclobuta Beta-Lactam Mimic | x-ray diffraction | A, B, C, D | — | — |
| 3LCE | Crystal structure of oxa-10 beta-lactamase covalently bound to cyclobutanone beta-lactam mimic | x-ray diffraction | A, B, C, D | — | — |
| 4S2O | OXA-10 in complex with Avibactam | x-ray diffraction | A, B | — | — |
| 4S2O | Oxa-10 in complex with avibactam | x-ray diffraction | A, B | — | — |
| 4WZ5 | Crystal structure of P. aeruginosa OXA10 | x-ray diffraction | A, B, C, D | — | — |
| 4WZ5 | Crystal structure of P. aeruginosa OXA10 | x-ray diffraction | A, B, C, D | — | — |
| 5FQ9 | Crystal structure of the OXA10 with 1C | x-ray diffraction | A, B | C6S, CL, NA | — |
| 5FQ9 | Crystal structure of the OXA10 with 1C | x-ray diffraction | A, B | — | — |
| 5MMY | Crystal structure of OXA10 with HEPES | x-ray diffraction | A, B | CL, CO3 | — |
| 5MMY | Crystal structure of OXA10 with hepes | x-ray diffraction | A, B | CL, CO3 | — |
| 5MNU | Oxa-10 avibactam complex with bound bromide | x-ray diffraction | A, B | BR, NA | — |
| 5MOX | Oxa-10 avibactam complex with bound CO2 | x-ray diffraction | A, B | NA, CO2 | — |
8 records more on the page itself.
Ligands
- NA · Sodium ion · in 8 records
- CL · Chloride ion · in 7 records
- CO2 · Carbon dioxide · in 2 records
- CO3 · Carbonate ion · in 2 records
- IOD · Iodide ion · in 2 records
- KJK · (3~{R})-3-[2-[4-(2-azanylethylamino) cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- BR · Bromide ion · in 1 record
- C6S · (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid · in 1 record
Experiment against prediction
- 4WZ5 chain B against the predicted model P14489: TM-score 1.00, RMSD 0.25 Å
- 4WZ5 chain B against the predicted model P14489: TM-score 1.00, RMSD 0.25 Å
- 4WZ5 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.26 Å
- 4WZ5 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.26 Å
- 3LCE chain B against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
- 3LCE chain B against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
- 1K56 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
- 1K56 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
- 1K57 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
- 1K57 chain A against the predicted model P14489: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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