ZZ7 · (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Binding sites

ZZ7 in 29 structures; the first of them:

• 2WKH · Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7 · ZZ7 A1265 · binds ALA66, SER67, MET99, GLN101, TRP102, VAL114, SER115, VAL117 and 9 more
• 3HUN · Crystal structure of Penicillin binding protein 4 from Staphylococcus aureus COL in… · ZZ7 A501 · binds SER75, SER116, ASN138, SER139, PHE241, LYS259, THR260, GLY261 and 3 more
• 4H0D · New Delhi Metallo-beta-Lactamase-1 Complexed with Mn from Klebsiella pneumoniae · ZZ7 A301 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 4HL1 · Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin · ZZ7 A301 · binds ILE35, MET67, VAL73, TRP93, HIS122, GLN123, ASP124, HIS189 and 6 more
• 4HL2 · New Delhi Metallo-beta-Lactamase-1 1.05 A structure Complexed with Hydrolyzed Ampicillin · ZZ7 A301 · binds LEU65, MET67, VAL73, TRP93, HIS122, GLN123, ASP124, HIS189 and 6 more
• 4RAW · Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with… · ZZ7 A301 · binds LEU65, VAL67, VAL73, TRP93, HIS122, GLN123, ASP124, HIS189 and 6 more
• 5O2F · Crystal structure of NDM-1 in complex with hydrolyzed ampicillin - new refinement · ZZ7 A303 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 11 more
• 5ZGE · Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin · ZZ7 A301 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 5ZGP · Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin · ZZ7 A304 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 5ZGQ · Crystal structure of NDM-1 at pH7.5 (Tris-HCl, (NH4)2SO4) in complex with hydrolyzed… · ZZ7 A304 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 5ZGR · Crystal structure of NDM-1 at pH7.3 (HEPES) in complex with hydrolyzed ampicillin · ZZ7 A303 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 6JKB · Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin · ZZ7 A303 · binds ILE9, VAL47, TRP67, HIS94, HIS96, GLN97, ASP98, GLU126 and 8 more
• 6OL8 · Crystal structure of NDM-12 metallo-beta-lactamase in complex with hydrolyzed ampicillin · ZZ7 A308 · binds LEU65, MET67, VAL73, TRP93, HIS120, HIS122, GLN123, ASP124 and 7 more
• 6XD7 · KPC-2 N170A mutant bound to hydrolyzed ampicillin at 1.65 A · ZZ7 A301 · binds CYS69, SER70, LYS73, TRP105, SER130, ASN132, GLU166, LEU167 and 6 more
• 7RCW · Crystal structure of C. difficile penicillin-binding protein 2 in complex with ampicillin · ZZ7 A1004 · binds GLY491, SER492, LYS495, TYR529, GLU549, SER550, ASN552, ILE706 and 9 more
• 7RCZ · Crystal structure of C. difficile SpoVD in complex with ampicillin · ZZ7 A809 · binds GLY310, SER311, LYS314, TRP349, SER367, ASN369, LYS512, THR513 and 5 more
• 8GJK · Multi-drug efflux pump RE-CmeB bound with ampicillin · ZZ7 C1101 · binds ILE136, VAL139, TYR328, VAL568, MET570, LEU612, PHE625, ILE627 and 2 more
• 8GPC · Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed ampicillin · ZZ7 A303 · binds ILE35, LEU65, MET67, VAL73, TRP93, HIS122, GLN123, ASP124 and 11 more
• 8ISQ · Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by… · ZZ7 A301 · binds CYS69, SER70, LYS73, HIS105, ILE129, SER130, ASN132, GLN166 and 8 more
• 5O2F · Crystal structure of ndm-1 in complex with hydrolyzed ampicillin - new refinement · ZZ7 A303 · binds MET67, TRP93, HIS122, GLN123, ASP124, HIS189, CYS208, LYS211 and 8 more
• 5ZGE · Crystal structure of ndm-1 at PH5.5 (bis-tris) in complex with hydrolyzed ampicillin · ZZ7 A301 · binds LEU65, MET67, TRP93, HIS122, GLN123, ASP124, HIS189, CYS208 and 5 more
• 5ZGP · Crystal structure of ndm-1 at PH6.2 (bis-tris) in complex with hydrolyzed ampicillin · ZZ7 A304 · binds LEU65, MET67, TRP93, HIS122, GLN123, ASP124, HIS189, CYS208 and 5 more

Residues it binds most

HIS 39, LEU 42, GLY 50, LYS 48, ASN 48, TRP 46, GLN 44, CYS 41, ASP 38, MET 35 (residue and the binding sites it lines).

Found with

• ZN · Zinc ion
• GOL · Glycerol
• SO4 · Sulfate ion
• PEG · Di(hydroxyethyl)ether
• CL · Chloride ion
• EDO · 1,2-ethanediol
• NA · Sodium ion
• OH · Hydroxide ion
• CD · Cadmium ion
• ACT · Acetate ion
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
• POL · N-propanol