UniProt P13702
3-hydroxy-3-methylglutaryl-coenzyme a reductase (P13702)
3-hydroxy-3-methylglutaryl-coenzyme a reductase (UniProt P13702): 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P13702
- Protein
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 3 · 1 record with a druggable one
Structures
23 records of P13702 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QAX | Ternary complex of pseudomonas mevalonii hmg-CoA reductase with hmg- CoA and NAD+ | x-ray diffraction | A, B | — | — |
| 1QAY | Ternary complex of pseudomonas mevalonii hmg-CoA reductase with mevalonate and NAD+ | x-ray diffraction | A, B | — | — |
| 1QAY | Ternary complex of pseudomonas mevalonii hmg-CoA reductase with mevalonate and NAD+ | x-ray diffraction | A, B | — | — |
| 1R31 | HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA | x-ray diffraction | A, B | — | — |
| 1R31 | Hmg-CoA reductase from pseudomonas mevalonii complexed with hmg-CoA | x-ray diffraction | A, B | — | — |
| 1R7I | HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. | x-ray diffraction | A, B | — | — |
| 1R7I | Hmg-CoA reductase from P. mevalonii, native structure at 2.2 ångströms resolution. | x-ray diffraction | A, B | — | — |
| 1T02 | Crystal structure of a Statin bound to class II HMG-CoA reductase | x-ray diffraction | A, B | — | — |
| 1T02 | Crystal structure of a statin bound to class II hmg-CoA reductase | x-ray diffraction | A, B | — | — |
| 4I4B | HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of… | x-ray diffraction | A, B | — | — |
| 4I4B | Hmg-CoA reductase from pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of… | x-ray diffraction | A, B | — | — |
| 4I56 | HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa | x-ray diffraction | A, B | — | — |
| 4I56 | Hmg-CoA reductase from pseudomonas mevalonii complexed with dithio- hmg-CoA | x-ray diffraction | A, B | — | — |
| 4I64 | 3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution… | x-ray diffraction | A, B | — | — |
| 4I64 | 3-hydroxy-3-methylglutaryl coenzyme a reductase from pseudomonas mevalonii, a high resolution… | x-ray diffraction | A, B | — | — |
| 4I6A | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with… | x-ray diffraction | A, B | — | — |
| 4I6A | 3-hydroxy-3-methylglutaryl (hmg) coenzyme a reductase from pseudomonas mevalonii complexed with… | x-ray diffraction | A, B | — | — |
| 4I6W | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate | x-ray diffraction | A, B | — | — |
| 4I6W | 3-hydroxy-3-methylglutaryl (hmg) coenzyme-a reductase complexed with thiomevalonate | x-ray diffraction | A, B | — | — |
| 4I6Y | 3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate | x-ray diffraction | A, B | — | — |
| 4I6Y | 3-hydroxy-3-methyl (hmg) coenzyme a reductase bound to R-mevalonate | x-ray diffraction | A, B | — | — |
| 8GDN | Structure of PmHMGR bound to mevalonate, CoA and NAD. | x-ray diffraction | A, B | COA, MEV, SO4, NAD | — |
| P13702 | AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (P13702) | predicted | A | — | 3 (best 0.70) |
Ligands
Experiment against prediction
- 4I6A chain A against the predicted model P13702: TM-score 0.99, RMSD 0.51 Å
- 4I6A chain A against the predicted model P13702: TM-score 0.99, RMSD 0.51 Å
- 1QAX chain B against the predicted model P13702: TM-score 0.99, RMSD 0.52 Å
- 1R7I chain A against the predicted model P13702: TM-score 0.99, RMSD 0.55 Å
- 1R7I chain A against the predicted model P13702: TM-score 0.99, RMSD 0.55 Å
- 4I64 chain A against the predicted model P13702: TM-score 0.99, RMSD 0.55 Å
- 4I64 chain A against the predicted model P13702: TM-score 0.99, RMSD 0.55 Å
- 4I6W chain A against the predicted model P13702: TM-score 0.99, RMSD 0.56 Å
- 4I6W chain A against the predicted model P13702: TM-score 0.99, RMSD 0.56 Å
- 1R31 chain A against the predicted model P13702: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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