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Ligand · 1CZ

1CZ · (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide

1CZ, (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid…

Component
1CZ
Formula
C27 H44 N7 O19 P3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

1CZ in 2 structures; the first of them:

  • 4I56 · HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa · 1CZ A501 · binds ARG11, SER66, ASN67, GLU83, PRO84, SER85, ILE86, ALA88 and 19 more
  • 4I56 · Hmg-CoA reductase from pseudomonas mevalonii complexed with dithio- hmg-CoA · 1CZ A501 · binds ARG11, SER66, ASN67, GLU83, PRO84, SER85, ILE86, ALA88 and 19 more

Residues it binds most

ALA 2, ARG 2, ASN 2, SER 2, GLU 2, GLY 2, ILE 2, LEU 2, GLN 2, HIS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol

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