UniProt P12830
Cadherin-1 (P12830)
Cadherin-1 (UniProt P12830): 33 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P12830
- Protein
- Cadherin-1
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 8 · 4 records with a druggable one
Structures
34 records of P12830 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1O6S | Internalin (Listeria monocytogenes) / E-Cadherin (human) Recognition Complex | x-ray diffraction | B | — | — |
| 1O6S | Internalin (listeria monocytogenes) / E-cadherin (human) recognition complex | x-ray diffraction | B | — | — |
| 2O72 | Crystal Structure Analysis of human E-cadherin (1-213) | x-ray diffraction | A | — | — |
| 2O72 | Crystal structure analysis of human E-cadherin (1-213) | x-ray diffraction | A | — | — |
| 2OMT | Crystal structure of InlA G194S+S/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMT | Crystal structure of inla G194S+S/HEC1 complex | x-ray diffraction | B | — | — |
| 2OMU | Crystal structure of InlA G194S+S Y369S/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMU | Crystal structure of inla G194S+S Y369S/HEC1 complex | x-ray diffraction | B | — | — |
| 2OMV | Crystal structure of InlA S192N Y369S/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMV | Crystal structure of inla S192N Y369S/HEC1 complex | x-ray diffraction | B | — | — |
| 2OMX | Crystal structure of InlA S192N G194S+S/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMX | Crystal structure of inla S192N G194S+S/HEC1 complex | x-ray diffraction | B | — | — |
| 2OMY | Crystal structure of InlA S192N/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMY | Crystal structure of inla S192N/HEC1 complex | x-ray diffraction | B | — | — |
| 2OMZ | Crystal structure of InlA Y369A/hEC1 complex | x-ray diffraction | B | — | — |
| 2OMZ | Crystal structure of inla Y369A/HEC1 complex | x-ray diffraction | B | — | — |
| 3FF7 | Structure of NK cell receptor KLRG1 bound to E-cadherin | x-ray diffraction | A, B | — | — |
| 3FF7 | Structure of nk cell receptor KLRG1 bound to E-cadherin | x-ray diffraction | A, B | — | — |
| 3FF8 | Structure of NK cell receptor KLRG1 bound to E-cadherin | x-ray diffraction | A, B | — | — |
| 3FF8 | Structure of nk cell receptor KLRG1 bound to E-cadherin | x-ray diffraction | A, B | — | — |
| 4ZT1 | Crystal structure of human E-Cadherin (residues 3-213) in x-dimer conformation | x-ray diffraction | A, B | CA | 1 (best 0.66) |
| 4ZT1 | Crystal structure of human E-cadherin (residues 3-213) in X-dimer conformation | x-ray diffraction | A, B | — | — |
| 4ZTE | Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic inhibitor | x-ray diffraction | A, B | CA, 4RL | 1 (best 0.68) |
| 4ZTE | Crystal structure of human E-cadherin (residues 3-213) in complex with a peptidomimetic inhibitor | x-ray diffraction | A, B | — | — |
| 6CXY | Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 | x-ray diffraction | C | CA | — |
| 6CXY | Crystal structure of human E-cadherin bound by mouse monoclonal antibody Fab mab-1_19A11 | x-ray diffraction | C | CA | — |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | y | MVM | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | y | MVM | — |
| 6OLG | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) | electron microscopy | A | MVM | — |
| 6VEL | Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab | x-ray diffraction | C | SO4, CA | 3 (best 0.61) |
| 6VEL | Crystal structure of human E-cadherin bound by mouse monoclonal antibody 66E8FAB | x-ray diffraction | C | SO4, CA | — |
| 7STZ | Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11 | x-ray diffraction | C, D | NAG, MAN, BMA, CA | 3 (best 0.78) |
| 7STZ | Crystal structure of human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mab-1_19A11 | x-ray diffraction | C, D | NAG, MAN, BMA, CA | — |
| P12830 | AlphaFold monomer V2.0 prediction for cadherin-1 (P12830) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 8 records
- MVM · N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide · in 3 records
- BMA · beta-D-mannopyranose · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- SO4 · Sulfate ion · in 2 records
- 4RL · N-{[(2S,5S)-1-benzyl-5-(2-{[(2S,3S)-1-(tert-butylamino)-3-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl)-3,6-dioxopiperazin-2-yl]methyl}-L-alpha-asparagine · in 1 record
Experiment against prediction
- 6VEL chain C against the predicted model P12830: TM-score 0.98, RMSD 0.82 Å
- 6VEL chain C against the predicted model P12830: TM-score 0.98, RMSD 0.82 Å
- 4ZTE chain A against the predicted model P12830: TM-score 0.98, RMSD 0.83 Å
- 4ZTE chain A against the predicted model P12830: TM-score 0.98, RMSD 0.83 Å
- 4ZT1 chain A against the predicted model P12830: TM-score 0.98, RMSD 0.84 Å
- 4ZT1 chain A against the predicted model P12830: TM-score 0.98, RMSD 0.84 Å
- 6CXY chain C against the predicted model P12830: TM-score 0.97, RMSD 0.99 Å
- 6CXY chain C against the predicted model P12830: TM-score 0.97, RMSD 0.99 Å
- 2O72 chain A against the predicted model P12830: TM-score 0.97, RMSD 1.02 Å
- 2O72 chain A against the predicted model P12830: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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