MolNFT v1 · #187740 · protein

Crystal structure of human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mab-1_19A11

7STZ: “Crystal structure of human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mab-1_19A11”. X-ray diffraction, 4 ligands (BMA, MAN, NAG). MolNFT v1 #187740 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7STZ
Type: protein
Length: 1,837 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P12830
Ligands: BMA, MAN, NAG, CA

Structure

x-ray diffraction · 5 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	—	protein	540	—	P12830
H	—	protein	219	—	—
L, M	—	protein	220	—	—
D	—	protein	422	—	P12830
I	—	protein	216	—	—

Ligands and binding sites

BMA · beta-D-mannopyranose · sugar · 12 copies · chains C, D
MAN · alpha-D-mannopyranose · sugar · 3 copies · chains C
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains C
CA · Calcium ion · metal · 24 copies · chains C, D, I, M
EDO · 1,2-ethanediol · additive · 5 copies · chains C, H, I
PG4 · Tetraethylene glycol · additive · 5 copies · chains C, H, L, D, I, M

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7STZ · Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab… · the same entry in another collection · chain M against M, TM-score 1.00
P12830 · AlphaFold monomer V2.0 prediction for cadherin-1 (P12830) · a predicted model of the same protein · chain C against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12830
Elsewhere: RCSB PDB 7STZ · PDBe 7STZ · UniProt P12830

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