UniProt P11586
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed (P11586)
C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed (UniProt P11586), EC 1.5.1.5, 3.5.4.9: 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 16 pockets. Binding sites, druggability and…
- UniProt
- P11586
- Protein
- C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
- EC
- 1.5.1.5, 3.5.4.9, 6.3.4.3
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 16 · 2 records with a druggable one
Structures
14 records of P11586 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A4I | Human tetrahydrofolate dehydrogenase / cyclohydrolase | x-ray diffraction | A, B | — | — |
| 1A4I | Human tetrahydrofolate dehydrogenase / cyclohydrolase | x-ray diffraction | A, B | — | — |
| 1DIA | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 1DIA | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 1DIB | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 1DIB | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 1DIG | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 1DIG | Human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with NADP and inhibitor… | x-ray diffraction | A, B | — | — |
| 6ECP | The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and… | x-ray diffraction | A, B | NAP | 5 (best 0.59) |
| 6ECP | The human methylenetetrahydrofolate DEHYDROGENASE/CYCLOHYDROLASE (fold) complexed with NADP and… | x-ray diffraction | A, B | NAP | — |
| 6ECQ | The human methylenetetrahydrofolate DEHYDROGENASE/CYCLOHYDROLASE (fold) complexed with NADP and… | x-ray diffraction | A, B | NAP, LUD | — |
| 6ECR | The human methylenetetrahydrofolate DEHYDROGENASE/CYCLOHYDROLASE (fold) complexed with NADP | x-ray diffraction | A, B | NAP | — |
| 9IUO | Human MTHFD1 in complex with compound 16d | x-ray diffraction | A, B, C, D | A1L25, NAP | 11 (best 0.73) |
| P11586 | AlphaFold monomer V2.0 prediction for C-1-tetrahydrofolate synthase, cytoplasmic (P11586) | predicted | A | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 5 records
- A1L25 · (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-methyl-phenyl]carbonylamino]pentanedioic acid · in 1 record
- LUD · N-{4-[(6AR)-3-amino-1,9-dioxo-1,2,5,6,6A,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzene-1-carbonyl}-L-glutamic acid · in 1 record
Experiment against prediction
- 1A4I chain A against the predicted model P11586: TM-score 0.98, RMSD 0.82 Å
- 1A4I chain A against the predicted model P11586: TM-score 0.98, RMSD 0.82 Å
- 6ECR chain A against the predicted model P11586: TM-score 0.98, RMSD 0.85 Å
- 6ECQ chain A against the predicted model P11586: TM-score 0.98, RMSD 0.90 Å
- 1DIA chain A against the predicted model P11586: TM-score 0.98, RMSD 0.83 Å
- 1DIA chain A against the predicted model P11586: TM-score 0.98, RMSD 0.83 Å
- 1DIG chain A against the predicted model P11586: TM-score 0.98, RMSD 0.84 Å
- 1DIG chain A against the predicted model P11586: TM-score 0.98, RMSD 0.84 Å
- 1DIB chain A against the predicted model P11586: TM-score 0.98, RMSD 0.86 Å
- 1DIB chain A against the predicted model P11586: TM-score 0.98, RMSD 0.86 Å
Elsewhere
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