UniProt P11558
Methyl-coenzyme M reductase I subunit alpha (P11558)
Methyl-coenzyme M reductase I subunit alpha (UniProt P11558), EC 2.8.4.1: 33 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P11558
- Protein
- Methyl-coenzyme M reductase I subunit alpha
- EC
- 2.8.4.1
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 27 · 3 records with a druggable one
Structures
34 records of P11558 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HBM | Methyl-coenzyme M reductase enzyme product complex | x-ray diffraction | A, D | — | — |
| 1HBM | Methyl-coenzyme M reductase enzyme product complex | x-ray diffraction | A, D | — | — |
| 1HBN | Methyl-coenzyme M reductase | x-ray diffraction | A, D | — | — |
| 1HBN | Methyl-coenzyme M reductase | x-ray diffraction | A, D | — | — |
| 1HBO | Methyl-coenzyme M reductase mcr-RED1-silent | x-ray diffraction | A, D | — | — |
| 1HBO | Methyl-coenzyme M reductase mcr-RED1-silent | x-ray diffraction | A, D | — | — |
| 1HBU | METHYL-COENZYME M REDUCTASE IN THE MCR-RED1-SILENT STATE IN COMPLEX with COENZYME M | x-ray diffraction | A, D | — | — |
| 1HBU | Methyl-coenzyme M reductase in the mcr-RED1-silent state in complex with coenzyme M | x-ray diffraction | A, D | — | — |
| 1MRO | Methyl-coenzyme M reductase | x-ray diffraction | A, D | — | — |
| 1MRO | Methyl-coenzyme M reductase | x-ray diffraction | A, D | — | — |
| 3M1V | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M1V | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3M2R | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M2R | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3M2U | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M2U | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3M2V | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M2V | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3M30 | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M30 | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3M32 | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | x-ray diffraction | A, D | — | — |
| 3M32 | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues | x-ray diffraction | A, D | — | — |
| 3POT | Structural analysis of a Ni(III)-methyl species in methyl-coenzyme M reductase from… | x-ray diffraction | A, D | — | — |
| 3POT | Structural analysis of a NI(III)-methyl species in methyl-coenzyme M reductase from… | x-ray diffraction | A, D | — | — |
| 5A0Y | Methyl-coenzyme M reductase from methanothermobacter marburgensis at 1.1 a resolution | x-ray diffraction | A, D | — | — |
| 5G0R | Methyl-coenzyme M reductase I from methanothermobacter marburgensis exposed to 3-nitrooxypropanol | x-ray diffraction | A, D | MG, F43, TP7, NA, K, CL | 9 (best 0.89) |
| 5G0R | Methyl-coenzyme M reductase I from methanothermobacter marburgensis exposed to 3-nitrooxypropanol | x-ray diffraction | A, D | — | — |
| 7B2H | Crystal structure of the methyl-coenzyme M reductase from Methanothermobacter Marburgensis… | x-ray diffraction | A, D | COM, TP7, K, F43, MG, XE | 9 (best 0.89) |
| 7B2H | Crystal structure of the methyl-coenzyme M reductase from methanothermobacter marburgensis… | x-ray diffraction | A, D | COM, K, F43, MG, XE, SO4 | — |
| 7SUC | XFEL Serial Crystallography Reveals the Room Temperature Structure of Methyl-Coenzyme M Reductase | x-ray diffraction | A, a | F43, COM, MG | — |
| 7SUC | Xfel serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase | x-ray diffraction | A, a | F43, COM, MG | — |
| 7SXM | Structure of Xenon-derivatized Methyl-Coenzyme M Reductase from Methanothermobacter marburgensis | x-ray diffraction | A, D | F43, MG, TP7, COM, NA, XE | 9 (best 0.89) |
| 7SXM | Structure of xenon-derivatized methyl-coenzyme M reductase from methanothermobacter marburgensis | x-ray diffraction | A, D | F43, MG, COM, NA, XE | — |
| P11558 | AlphaFold monomer V2.0 prediction for methyl-coenzyme M reductase I subunit alpha (P11558) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5G0R chain A against the predicted model P11558: TM-score 1.00, RMSD 0.18 Å
- 5G0R chain D against the predicted model P11558: TM-score 1.00, RMSD 0.20 Å
- 7B2H chain A against the predicted model P11558: TM-score 1.00, RMSD 0.22 Å
- 7SXM chain A against the predicted model P11558: TM-score 1.00, RMSD 0.22 Å
- 1MRO chain D against the predicted model P11558: TM-score 1.00, RMSD 0.24 Å
- 1MRO chain D against the predicted model P11558: TM-score 1.00, RMSD 0.24 Å
- 7SXM chain D against the predicted model P11558: TM-score 1.00, RMSD 0.25 Å
- 7SXM chain D against the predicted model P11558: TM-score 1.00, RMSD 0.25 Å
- 7B2H chain D against the predicted model P11558: TM-score 1.00, RMSD 0.26 Å
- 7SUC chain a against the predicted model P11558: TM-score 1.00, RMSD 0.27 Å
Elsewhere
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