UniProt P11233
Ras-related protein Ral-A (P11233)
Ras-related protein Ral-A (UniProt P11233), EC 3.6.5.-: 26 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P11233
- Protein
- Ras-related protein Ral-A
- EC
- 3.6.5.-
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 14 · 3 records with a druggable one
Structures
27 records of P11233 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UAD | Crystal structure of the RalA-GppNHp-Sec5 Ral-binding domain complex | x-ray diffraction | A, B | — | — |
| 1UAD | Crystal structure of the rala-gppnhp-SEC5 ral-binding domain complex | x-ray diffraction | A, B | — | — |
| 1ZC3 | Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA | x-ray diffraction | A, C | — | — |
| 1ZC3 | Crystal structure of the ral-binding domain of EXO84 in complex with the active rala | x-ray diffraction | A, C | — | — |
| 1ZC4 | Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA | x-ray diffraction | A, C | — | — |
| 1ZC4 | Crystal structure of the ral-binding domain of EXO84 in complex with the active rala | x-ray diffraction | A, C | — | — |
| 2A78 | Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme | x-ray diffraction | A | — | — |
| 2A78 | Crystal structure of the C3BOT-rala complex reveals a novel type of action of a bacterial exoenzyme | x-ray diffraction | A | — | — |
| 2A9K | Crystal structure of the C3bot-NAD-RalA complex reveals a novel type of action of a bacterial… | x-ray diffraction | A | — | — |
| 2A9K | Crystal structure of the C3BOT-NAD-rala complex reveals a novel type of action of a bacterial… | x-ray diffraction | A | — | — |
| 2BOV | Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase | x-ray diffraction | A | — | — |
| 2BOV | Molecular recognition of an ADP-ribosylating clostridium botulinum C3 exoenzyme by rala GTPase | x-ray diffraction | A | — | — |
| 6P0I | Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | GDP, NL7, CA, CL, NA | 2 (best 0.50) |
| 6P0I | Crystal structure of GDP-bound human rala in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | GDP, NL7, CA, CL, NA | — |
| 6P0J | Crystal structure of GDP-bound human rala | x-ray diffraction | B | GDP, CA | — |
| 6P0K | Crystal structure of GDP-bound human rala in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | CA, NLV, GDP | — |
| 6P0L | Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | CA, NLJ, GDP | 2 (best 0.44) |
| 6P0L | Crystal structure of GDP-bound human rala in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | CA, NLJ, GDP | — |
| 6P0M | Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | NLM, CA, CL, GDP | 2 (best 0.44) |
| 6P0M | Crystal structure of GDP-bound human rala in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | NLM, CA, CL, GDP | — |
| 6P0N | Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | CA, CL, NLS, GDP | 2 (best 0.43) |
| 6P0N | Crystal structure of GDP-bound human rala in a covalent complex with aryl sulfonyl fluoride… | x-ray diffraction | B | CA, CL, NLS, GDP | — |
| 6P0O | Crystal structure of GDP-bound human RalA | x-ray diffraction | B | GDP, CA | 2 (best 0.48) |
| 6P0O | Crystal structure of GDP-bound human rala | x-ray diffraction | B | GDP, CA | — |
| 8FJH | Crystal structure of RalA in a covalent complex with SOF-531 | x-ray diffraction | B | GDP, Y0P, CA | 1 (best 0.57) |
| 8FJI | Crystal structure of RalA in a covalent complex with SOF-367 | x-ray diffraction | B | GDP, Y0M, CA | 1 (best 0.57) |
| P11233 | AlphaFold monomer V2.0 prediction for RAS-related protein ral-a (P11233) | predicted | A | — | 2 (best 0.53) |
Ligands
- CA · Calcium ion · in 14 records
- GDP · Guanosine-5'-diphosphate · in 14 records
- CL · Chloride ion · in 6 records
- NA · Sodium ion · in 2 records
- NL7 · 4-[(5-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid · in 2 records
- NLJ · 4-[(2-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid · in 2 records
- NLM · 4-[(3-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid · in 2 records
- NLS · 4-[(6-fluoropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid · in 2 records
- NLV · 4-[(6-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid · in 1 record
- Y0M · 8-[fluoro(dihydroxy)-lambda~4~-sulfanyl]-N-(2-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxine-5-sulfonamide · in 1 record
- Y0P · 8-[bis(oxidanyl)-$l^{3}-sulfanyl]-~{N}-(3-fluoranyl-5-methoxy-phenyl)-2,3-dihydro-1,4-benzodioxine-5-sulfonamide · in 1 record
Experiment against prediction
- 1ZC4 chain A against the predicted model P11233: TM-score 0.99, RMSD 0.47 Å
- 1ZC4 chain A against the predicted model P11233: TM-score 0.99, RMSD 0.47 Å
- 1ZC3 chain A against the predicted model P11233: TM-score 0.99, RMSD 0.48 Å
- 1ZC3 chain A against the predicted model P11233: TM-score 0.99, RMSD 0.48 Å
- 1UAD chain A against the predicted model P11233: TM-score 0.99, RMSD 0.65 Å
- 1UAD chain A against the predicted model P11233: TM-score 0.99, RMSD 0.65 Å
- 2A9K chain A against the predicted model P11233: TM-score 0.97, RMSD 0.91 Å
- 2A9K chain A against the predicted model P11233: TM-score 0.97, RMSD 0.91 Å
- 2A78 chain A against the predicted model P11233: TM-score 0.97, RMSD 0.92 Å
- 2A78 chain A against the predicted model P11233: TM-score 0.97, RMSD 0.92 Å
Elsewhere
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