UniProt P10824

Guanine nucleotide-binding protein G(i) subunit alpha-1 (P10824)

Guanine nucleotide-binding protein G(i) subunit alpha-1 (UniProt P10824): 83 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P10824
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-1
Experimental structures: 83
Predicted models: 1
Ligands: 3
Pockets: 50 · 7 records with a druggable one

Structures

84 records of P10824 in the MolNFT archive: 83 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1AGR	Complex of ALF4-activated gi-alpha-1 with RGS4	x-ray diffraction	A, D	—	—
1AGR	Complex of ALF4-activated gi-alpha-1 with RGS4	x-ray diffraction	A, D	—	—
1AS0	GTP-gamma-S bound G42V GIA1	x-ray diffraction	A	—	—
1AS0	GTP-gamma-S bound G42V GIA1	x-ray diffraction	A	—	—
1AS2	GDP+PI bound G42V GIA1	x-ray diffraction	A	—	—
1AS2	GDP+PI bound G42V GIA1	x-ray diffraction	A	—	—
1AS3	GDP bound G42V GIA1	x-ray diffraction	A	—	—
1AS3	GDP bound G42V GIA1	x-ray diffraction	A	—	—
1BH2	A326S mutant of an inhibitory alpha subunit	x-ray diffraction	A	—	—
1BH2	A326S mutant of an inhibitory alpha subunit	x-ray diffraction	A	—	—
1BOF	Gi-alpha-1 bound to GDP and magnesium	x-ray diffraction	A	—	—
1BOF	Gi-alpha-1 bound to GDP and magnesium	x-ray diffraction	A	—	—
1CIP	Gi-alpha-1 subunit of guanine nucleotide-binding protein complexed with a GTP analogue	x-ray diffraction	A	—	—
1CIP	Gi-alpha-1 subunit of guanine nucleotide-binding protein complexed with a GTP analogue	x-ray diffraction	A	—	—
1FQJ	Crystal structure of the heterotrimeric complex of the rgs domain of RGS9, the gamma subunit of…	x-ray diffraction	A, D	—	—
1FQJ	Crystal structure of the heterotrimeric complex of the rgs domain of RGS9, the gamma subunit of…	x-ray diffraction	A, D	—	—
1FQK	Crystal structure of the heterodimeric complex of the rgs domain of RGS9, and the GT/I1 chimera…	x-ray diffraction	A, C	—	—
1FQK	Crystal structure of the heterodimeric complex of the rgs domain of RGS9, and the GT/I1 chimera…	x-ray diffraction	A, C	—	—
1GDD	Tertiary and quaternary structural changes in GIA1 induced by GTP hydrolysis	x-ray diffraction	A	—	—
1GDD	Tertiary and quaternary structural changes in GIA1 induced by GTP hydrolysis	x-ray diffraction	A	—	—
1GFI	Structures of active conformations of gi alpha 1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GFI	Structures of active conformations of gi alpha 1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GG2	G protein heterotrimer mutant GI_ALPHA_1(G203A) BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	A	—	—
1GG2	G protein heterotrimer mutant GI_ALPHA_1(G203A) BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	A	—	—
1GIA	Structure of active conformations of GIA1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GIA	Structure of active conformations of GIA1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GIL	Structure of active conformations of GIA1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GIL	Structure of active conformations of GIA1 and the mechanism of GTP hydrolysis	x-ray diffraction	A	—	—
1GIT	Structure of GTP-binding protein	x-ray diffraction	A	—	—
1GIT	Structure of GTP-binding protein	x-ray diffraction	A	—	—
1GP2	G protein heterotrimer GI_ALPHA_1 BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	A	—	—
1GP2	G protein heterotrimer GI_ALPHA_1 BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	A	—	—
1SHZ	Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera	x-ray diffraction	A, D	—	—
1SHZ	Crystal structure of the P115RHOGEF rgrgs domain in a complex with GALPHA(13):GALPHA(I1) chimera	x-ray diffraction	A, D	—	—
1SVK	Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP	x-ray diffraction	A	—	—
1SVK	Structure of the K180P mutant of gi alpha subunit bound to ALF4 and GDP	x-ray diffraction	A	—	—
1SVS	Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.	x-ray diffraction	A	—	—
1SVS	Structure of the K180P mutant of gi alpha subunit bound to gppnhp.	x-ray diffraction	A	—	—
2BCJ	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma…	x-ray diffraction	Q	—	—
2BCJ	Crystal structure of G protein-coupled receptor kinase 2 in complex with galpha-Q and gbetagamma…	x-ray diffraction	Q	—	—
2RGN	Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA	x-ray diffraction	A, D	—	—
2RGN	Crystal structure of P63RHOGEF complex with galpha-Q and rhoa	x-ray diffraction	A, D	—	—
2ZJY	Structure of the K349P mutant of Gi alpha 1 subunit bound to ALF4 and GDP	x-ray diffraction	A	—	—
2ZJY	Structure of the K349P mutant of gi alpha 1 subunit bound to ALF4 and GDP	x-ray diffraction	A	—	—
2ZJZ	Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP	x-ray diffraction	A, B	—	—
2ZJZ	Structure of the K349P mutant of gi alpha 1 subunit bound to GDP	x-ray diffraction	A, B	—	—
3AH8	Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890	x-ray diffraction	A	—	—
3AH8	Structure of heterotrimeric G protein galpha-Q beta gamma in complex with an inhibitor ym-254890	x-ray diffraction	A	—	—
3D7M	Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C	x-ray diffraction	A	—	—
3D7M	Crystal structure of the G protein fast-exchange double mutant I56C/Q333C	x-ray diffraction	A	—	—
3FFA	Crystal Structure of a fast activating G protein mutant	x-ray diffraction	A	—	—
3FFA	Crystal structure of a fast activating G protein mutant	x-ray diffraction	A	—	—
3FFB	Gi-alpha-1 mutant in GDP bound form	x-ray diffraction	A	—	—
3FFB	Gi-alpha-1 mutant in GDP bound form	x-ray diffraction	A	—	—
3V00	Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein…	x-ray diffraction	C, B, A	—	—
3V00	Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein…	x-ray diffraction	C, B, A	—	—
4N0D	Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS	x-ray diffraction	A	—	—
4N0D	Crystal structure of the K345L variant of the gi ALPHA1 subunit bound to gtpgammas	x-ray diffraction	A	—	—
4N0E	Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP	x-ray diffraction	A	—	—
4N0E	Crystal structure of the K345L variant of the gi ALPHA1 subunit bound to GDP	x-ray diffraction	A	—	—

24 records more on the page itself.

Ligands

GSP · 5'-guanosine-diphosphate-monothiophosphate · in 3 records
MG · Magnesium ion · in 3 records
GDP · Guanosine-5'-diphosphate · in 2 records

Experiment against prediction

5KDL chain A against the predicted model P10824: TM-score 0.99, RMSD 0.57 Å
5KDL chain A against the predicted model P10824: TM-score 0.99, RMSD 0.57 Å
1FQK chain A against the predicted model P10824: TM-score 0.99, RMSD 0.72 Å
1FQK chain A against the predicted model P10824: TM-score 0.99, RMSD 0.72 Å
2BCJ chain Q against the predicted model P21279: TM-score 0.99, RMSD 0.73 Å
2BCJ chain Q against the predicted model P21279: TM-score 0.99, RMSD 0.73 Å
3D7M chain A against the predicted model P10824: TM-score 0.99, RMSD 0.71 Å
3D7M chain A against the predicted model P10824: TM-score 0.99, RMSD 0.71 Å
5KDL chain B against the predicted model P10824: TM-score 0.99, RMSD 0.73 Å
5KDL chain B against the predicted model P10824: TM-score 0.99, RMSD 0.73 Å

Elsewhere

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