UniProt P10721
Isoform 2 of Mast/stem cell growth factor receptor Kit (P10721)
Isoform 2 of Mast/stem cell growth factor receptor Kit (UniProt P10721), EC 2.7.10.1: 44 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 24 pockets. Binding sites, druggability and experiment against…
- UniProt
- P10721
- Protein
- Isoform 2 of Mast/stem cell growth factor receptor Kit
- EC
- 2.7.10.1
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 24 · 3 records with a druggable one
Structures
45 records of P10721 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PKG | Structure of a c-Kit Kinase Product Complex | x-ray diffraction | A | — | — |
| 1PKG | Structure of a C-kit kinase product complex | x-ray diffraction | A | — | — |
| 1T45 | Structural basis for the autoinhibition and sti-571 inhibition of C-kit tyrosine kinase | x-ray diffraction | A | — | — |
| 1T45 | Structural basis for the autoinhibition and sti-571 inhibition of C- kit tyrosine kinase | x-ray diffraction | A | — | — |
| 1T46 | Structural basis for the autoinhibition and sti-571 inhibition of C-kit tyrosine kinase | x-ray diffraction | A | — | — |
| 1T46 | Structural basis for the autoinhibition and sti-571 inhibition of C- kit tyrosine kinase | x-ray diffraction | A | — | — |
| 2E9W | Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF) | x-ray diffraction | A, B | — | — |
| 2E9W | Crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) | x-ray diffraction | A, B | — | — |
| 2EC8 | Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit | x-ray diffraction | A | — | — |
| 2EC8 | Crystal structure of the exctracellular domain of the receptor tyrosine kinase, kit | x-ray diffraction | A | — | — |
| 2VIF | Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide | x-ray diffraction | P | — | — |
| 2VIF | Crystal structure of SOCS6 SH2 domain in complex with a C-kit phosphopeptide | x-ray diffraction | P | — | — |
| 3G0E | KIT kinase domain in complex with sunitinib | x-ray diffraction | A | — | — |
| 3G0E | Kit kinase domain in complex with sunitinib | x-ray diffraction | A | — | — |
| 3G0F | KIT kinase domain mutant D816H in complex with sunitinib | x-ray diffraction | A, B | — | — |
| 3G0F | Kit kinase domain mutant D816H in complex with sunitinib | x-ray diffraction | A, B | — | — |
| 4HVS | Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647 | x-ray diffraction | A | — | — |
| 4HVS | Crystal structure of kit kinase domain with a small molecule inhibitor, PLX647 | x-ray diffraction | A | — | — |
| 4K94 | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19 | x-ray diffraction | C | — | — |
| 4K94 | Crystal structure of kit D4D5 fragment in complex with anti-kit antibody FAB19 | x-ray diffraction | C | — | — |
| 4K9E | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D | x-ray diffraction | C | — | — |
| 4K9E | Crystal structure of kit D4D5 fragment in complex with anti-kit antibodies FAB79D | x-ray diffraction | C | — | — |
| 4PGZ | Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a… | x-ray diffraction | C, A, B | — | — |
| 4PGZ | Structural basis of kit activation by oncogenic mutations in the extracellular region reveals a… | x-ray diffraction | C, A, B | — | — |
| 4U0I | Crystal structure of KIT in complex with ponatinib | x-ray diffraction | A | — | — |
| 4U0I | Crystal structure of kit in complex with ponatinib | x-ray diffraction | A | — | — |
| 6GQJ | Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 18) | x-ray diffraction | A, B | F82 | — |
| 6GQJ | Crystal structure of human C-kit kinase domain in complex with AZD3229-analogue (compound 18) | x-ray diffraction | A, B | F82 | — |
| 6GQK | Crystal structure of human C-kit kinase domain in complex with AZD3229-analogue (compound 23) | x-ray diffraction | A, B | F88 | — |
| 6GQL | Crystal structure of human C-kit kinase domain in complex with AZD3229-analogue (compound 35) | x-ray diffraction | A, B | F8B | — |
| 6GQM | Crystal structure of human c-KIT kinase domain in complex with a small molecule inhibitor, AZD3229 | x-ray diffraction | A, B | F8H, CL | — |
| 6GQM | Crystal structure of human C-kit kinase domain in complex with a small molecule inhibitor, AZD3229 | x-ray diffraction | A, B | F8H, CL | — |
| 6HH1 | Structure of C-kit with allosteric inhibitor 3G8 | x-ray diffraction | A | PO4, G4E | — |
| 6ITT | Crystal structure of unactivated C-kit in complex with compound | x-ray diffraction | A, B | AWO | — |
| 6ITV | Crystal structure of activated C-kit in complex with compound | x-ray diffraction | A | AWO | — |
| 6KLA | Crystal structure of human C-kit kinase domain in complex with compound 15A | x-ray diffraction | A | DJX | — |
| 6MOB | Crystal structure of KIT1 in complex with DP2976 via co-crystallization | x-ray diffraction | A | NO3, JWY | — |
| 6MOB | Crystal structure of KIT1 in complex with DP2976 via co- crystallization | x-ray diffraction | A | NO3, JWY | — |
| 6XV9 | Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor | x-ray diffraction | A, B | O35 | 2 (best 0.83) |
| 6XV9 | Crystal structure of the kinase domain of human C-kit in complex with a type-II inhibitor | x-ray diffraction | A, B | O35 | — |
| 6XVA | Crystal structure of the kinase domain of human C-kit in complex with a type-II inhibitor bearing… | x-ray diffraction | A, B | O2K | — |
| 6XVB | Crystal structure of the kinase domain of human C-kit with a cyclic imidate inhibitor covalently… | x-ray diffraction | A, B | O2H | — |
| 8DFM | Ectodomain of full-length wild-type KIT-SCF dimers | electron microscopy | A, B | NAG | 8 (best 0.64) |
| 8DFQ | Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers | electron microscopy | A, B | NAG | 14 (best 0.64) |
| P10721 | AlphaFold monomer V2.0 prediction for MAST/STEM cell growth factor receptor kit (P10721) | predicted | A | — | — |
Ligands
- AWO · N-(5-ethyl-1,2-oxazol-3-yl)-N'-[4-(2-{[6-(4-ethylpyrazin-1(4H)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea · in 2 records
- CL · Chloride ion · in 2 records
- F82 · 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide · in 2 records
- F8H · ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl) ethanamide · in 2 records
- JWY · N-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- NO3 · Nitrate ion · in 2 records
- O35 · ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide · in 2 records
- DJX · N-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine · in 1 record
- F88 · ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide · in 1 record
- F8B · ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide · in 1 record
- G4E · ~{N}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{H}-1,2,4-triazol-3-amine · in 1 record
- O2H · ~{N}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide · in 1 record
- O2K · ~{N}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 6GQM chain B against the predicted model P10721: TM-score 0.97, RMSD 1.27 Å
- 6GQM chain B against the predicted model P10721: TM-score 0.97, RMSD 1.27 Å
- 6GQM chain A against the predicted model P10721: TM-score 0.97, RMSD 1.32 Å
- 6GQM chain A against the predicted model P10721: TM-score 0.97, RMSD 1.32 Å
- 6XVB chain B against the predicted model P10721: TM-score 0.97, RMSD 1.28 Å
- 6XVA chain A against the predicted model P10721: TM-score 0.97, RMSD 1.29 Å
- 6XVB chain A against the predicted model P10721: TM-score 0.97, RMSD 1.35 Å
- 6XVA chain B against the predicted model P10721: TM-score 0.97, RMSD 1.29 Å
- 8DFM chain B against the predicted model P10721: TM-score 0.97, RMSD 1.39 Å
- 6GQL chain B against the predicted model P10721: TM-score 0.97, RMSD 1.34 Å
Elsewhere
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