Ligand · O35
O35 · ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide
O35, ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide (C28 H30 N4 O4, 486.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding…
- Component
- O35
- Formula
- C28 H30 N4 O4
- Class
- ligand
- Structures
- 3
- PDB entries
- 2
Binding sites
O35 in 3 structures; the first of them:
- 6XV9 · Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor · O35 A1001 · binds TYR568, LEU595, VAL603, ALA621, VAL622, LYS623, GLU640, VAL643 and 19 more
- 6XV9 · Crystal structure of the kinase domain of human C-kit in complex with a type-II inhibitor · O35 A1001 · binds LEU595, VAL603, ALA621, VAL622, LYS623, GLU640, VAL643, LEU644 and 14 more
- 6XVJ · Crystal structure of the kdr (VEGFR2) kinase domain in complex with a type-II inhibitor · O35 A1201 · binds LEU840, VAL848, ALA866, VAL867, LYS868, GLU885, ILE888, LEU889 and 16 more
Residues it binds most
VAL 5, LEU 5, CYS 5, ILE 5, GLU 5, LYS 5, PHE 5, ALA 5, ASP 5, GLY 5 (residue and the binding sites it lines).
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