UniProt P10686
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (P10686)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (UniProt P10686), EC 3.1.4.11: 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 81 pockets. Binding sites, druggability and…
- UniProt
- P10686
- Protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- EC
- 3.1.4.11
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 81 · 9 records with a druggable one
Structures
21 records of P10686 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y0M | Crystal structure of of the SH3 domain of phospholipase C Gamma-1 | x-ray diffraction | A | — | — |
| 1Y0M | Crystal structure of of the SH3 domain of phospholipase C gamma-1 | x-ray diffraction | A | — | — |
| 1YWO | Phospholipase Cgamma1 SH3 in complex with a SLP-76 motif | x-ray diffraction | A | — | — |
| 1YWO | Phospholipase CGAMMA1 SH3 in complex with a slp-76 motif | x-ray diffraction | A | — | — |
| 1YWP | Phospholipase Cgamma1 SH3 | x-ray diffraction | A | — | — |
| 1YWP | Phospholipase CGAMMA1 SH3 | x-ray diffraction | A | — | — |
| 2FJL | Solution Structure of the Split PH domain in Phospholipase C-gamma1 | solution nmr | A | — | 2 (best 0.53) |
| 2FJL | Solution structure of the split pH domain in phospholipase C-GAMMA1 | solution nmr | A | — | 2 (best 0.53) |
| 3GQI | Crystal Structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | B | — | 5 (best 0.53) |
| 3GQI | Crystal structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | B | — | 5 (best 0.53) |
| 4K44 | Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes | x-ray diffraction | A, B | — | 1 (best 0.33) |
| 4K44 | Auto-inhibition and phosphorylation-induced activation of plc-gamma isozymes | x-ray diffraction | A, B | — | 1 (best 0.33) |
| 4K45 | Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes | x-ray diffraction | A, B | — | — |
| 4K45 | Auto-inhibition and phosphorylation-induced activation of plc-gamma isozymes | x-ray diffraction | A, B | — | — |
| 5EG3 | Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2… | x-ray diffraction | B | — | 1 (best 0.49) |
| 5EG3 | Crystal structure of the activated FGF receptor 2 (FGFR2) kinase domain in complex with the CSH2… | x-ray diffraction | B | — | 1 (best 0.49) |
| 6PBC | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated… | x-ray diffraction | A | CA, NA | 11 (best 0.76) |
| 6PBC | Structural basis for the activation of plc-gamma isozymes by phosphorylation and cancer-associated… | x-ray diffraction | A | CA, NA | 11 (best 0.76) |
| 7Z3J | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | x-ray diffraction | A | CA, I3P | 12 (best 0.76) |
| 7Z3J | Structure of crystallisable rat phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | x-ray diffraction | A | CA, I3P | 12 (best 0.76) |
| P10686 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase… | predicted | A | — | 17 (best 0.79) |
Ligands
Experiment against prediction
- 6PBC chain A against the predicted model P10686: TM-score 0.99, RMSD 0.89 Å
- 6PBC chain A against the predicted model P10686: TM-score 0.99, RMSD 0.89 Å
- 7Z3J chain A against the predicted model P10686: TM-score 0.99, RMSD 1.24 Å
- 7Z3J chain A against the predicted model P10686: TM-score 0.99, RMSD 1.24 Å
- 1YWO chain A against the predicted model P10686: TM-score 0.98, RMSD 0.36 Å
- 1YWO chain A against the predicted model P10686: TM-score 0.98, RMSD 0.36 Å
- 5EG3 chain B against the predicted model P10686: TM-score 0.94, RMSD 1.37 Å
- 5EG3 chain B against the predicted model P10686: TM-score 0.94, RMSD 1.37 Å
- 1Y0M chain A against the predicted model P10686: TM-score 0.94, RMSD 0.82 Å
- 1Y0M chain A against the predicted model P10686: TM-score 0.94, RMSD 0.82 Å
Elsewhere
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