MolNFT v1 · #97115 · protein
Auto-inhibition and phosphorylation-induced activation of plc-gamma isozymes
4K44 · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase…: “Auto-inhibition and phosphorylation-induced activation of plc-gamma isozymes”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #97115 on GenesisL1: 3D…
- PDB
- 4K44
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- EC
- 3.1.4.11
- UniProt
- P10686
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) | protein | 104 | 21% helix, 37% strand | P10686 |
| B | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) | protein | 105 | 21% helix, 35% strand | P10686 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.33 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 860 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4K44 · Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes · the same entry in another collection · chain A against A, TM-score 1.00
- P10686 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10686
- Elsewhere: RCSB PDB 4K44 · PDBe 4K44 · UniProt P10686
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