MolNFT v1 · #36887 · protein

Solution structure of the split pH domain in phospholipase C-GAMMA1

2FJL · 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase…: “Solution structure of the split pH domain in phospholipase C-GAMMA1”. Solution nmr, 2 pockets (best druggability 0.53). MolNFT v1 #36887 on GenesisL1: 3D structure…

PDB: 2FJL
Type: protein
Length: 150 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
EC: 3.1.4.11
UniProt: P10686
Pockets: 2 · best druggability 0.53

Structure

solution nmr · 1 distinct chain · 12% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11)	protein	150	12% helix, 27% strand	P10686

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.53	0.80	30	empty
2	117	0.43	0.77	22	empty

Compared structures

2FJL · Solution Structure of the Split PH domain in Phospholipase C-gamma1 · the same entry in another collection · chain A against A, TM-score 1.00
P10686 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10686
Elsewhere: RCSB PDB 2FJL · PDBe 2FJL · UniProt P10686

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