Research workbench
Solution structure of the split pH domain in phospholipase C-GAMMA1
Analyse Solution structure of the split pH domain in phospholipase C-GAMMA1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FJL
- Type
- protein
- Length
- 150 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
- EC
- 3.1.4.11
- UniProt
- P10686
- Pockets
- 2 · best druggability 0.53
Structure
solution nmr · 1 distinct chain · 12% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) | protein | 150 | 12% helix, 27% strand | P10686 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.53 | 0.80 | 30 | empty |
| 2 | 117 | 0.43 | 0.77 | 22 | empty |
Compared structures
- 2FJL · Solution Structure of the Split PH domain in Phospholipase C-gamma1 · the same entry in another collection · chain A against A, TM-score 1.00
- P10686 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10686
- Elsewhere: RCSB PDB 2FJL · PDBe 2FJL · UniProt P10686
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