UniProt P10121
Signal recognition particle receptor FtsY (P10121)
Signal recognition particle receptor FtsY (UniProt P10121): 35 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P10121
- Protein
- Signal recognition particle receptor FtsY
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 21 · 7 records with a druggable one
Structures
36 records of P10121 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FTS | Signal recognition particle receptor from E. COLI | x-ray diffraction | A | — | — |
| 1FTS | Signal recognition particle receptor from E. COLI | x-ray diffraction | A | — | — |
| 2QY9 | Structure of the NG+1 construct of the E. coli SRP receptor FtsY | x-ray diffraction | A | — | — |
| 2QY9 | Structure of the NG+1 construct of the E. COLI srp receptor ftsy | x-ray diffraction | A | — | — |
| 2XXA | The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR) | x-ray diffraction | B, D | — | — |
| 2XXA | The crystal structure of the signal recognition particle (srp) in complex with its RECEPTOR(SR) | x-ray diffraction | B, D | — | — |
| 2YHS | Structure of the E. coli SRP receptor FtsY | x-ray diffraction | A | — | — |
| 2YHS | Structure of the E. COLI srp receptor ftsy | x-ray diffraction | A | — | — |
| 3ZN8 | Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex | electron microscopy | D | — | — |
| 3ZN8 | Structural basis of signal sequence surveillance and selection by the srp-sr complex | electron microscopy | D | — | — |
| 4C7O | The structural basis of FtsY recruitment and GTPase activation by SRP RNA | x-ray diffraction | B, D | — | — |
| 4C7O | The structural basis of ftsy recruitment and GTPase activation by srp RNA | x-ray diffraction | B, D | — | — |
| 5GAD | RNC-SRP-SR complex early state | electron microscopy | l | GNP, MG | 1 (best 0.82) |
| 5GAD | Rnc-srp-sr complex early state | electron microscopy | l | — | — |
| 5NCO | Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome | electron microscopy | l | GDP, ALF, MG | 1 (best 0.83) |
| 6CQP | High resolution crystal structure of ftsy-ng domain of E. COLI | x-ray diffraction | A, B | NA | — |
| 6CS8 | High resolution crystal structure of FtsY-NG domain of E. coli | x-ray diffraction | A, B | F9Y, NA | 1 (best 0.80) |
| 6CS8 | High resolution crystal structure of ftsy-ng domain of E. COLI | x-ray diffraction | A, B | F9Y, NA | — |
| 6CVD | High resolution crystal structure of FtsY-NG domain of E. coli bound to fragment 1 | x-ray diffraction | A, B | 4ME, NH4, NA | 2 (best 0.82) |
| 6CVD | High resolution crystal structure of ftsy-ng domain of E. COLI bound to fragment 1 | x-ray diffraction | A, B | 4ME, NH4, NA | — |
| 6FPK | Co-translational folding intermediate dictates membrane targeting of the signal recognition… | x-ray diffraction | A | — | — |
| 6FPK | Co-translational folding intermediate dictates membrane targeting of the signal recognition… | x-ray diffraction | A | — | — |
| 6FPR | Co-translational folding intermediate dictates membrane targeting of the signal recognition… | x-ray diffraction | A, B | — | — |
| 6FPR | Co-translational folding intermediate dictates membrane targeting of the signal recognition… | x-ray diffraction | A, B | — | — |
| 6FQD | Escherichia Coli Signal Recognition Particle Receptor FtsY NGdN1 | x-ray diffraction | A, B | K, GDP | 7 (best 0.67) |
| 6FQD | Escherichia COLI signal recognition particle receptor ftsy NGDN1 | x-ray diffraction | A, B | K, GDP | — |
| 6N5I | FtsY-NG high-resolution | x-ray diffraction | A, B | K | 6 (best 0.82) |
| 6N5I | Ftsy-ng high-resolution | x-ray diffraction | A, B | K | — |
| 6N5J | Ftsy-ng high-resolution | x-ray diffraction | A, B | NH4 | — |
| 6N6N | Ftsy-ng high-resolution | x-ray diffraction | A, B | GCP, MG | — |
| 6N9B | FtsY-NG ultra high-resolution | x-ray diffraction | A, B | — | — |
| 6N9B | Ftsy-ng ultra high-resolution | x-ray diffraction | A, B | — | — |
| 6NC1 | FtsY-NG high-resolution | x-ray diffraction | A, B | GDP, K, MG | 3 (best 0.81) |
| 6NC1 | Ftsy-ng high-resolution | x-ray diffraction | A, B | GDP, MG, K | — |
| 6NC4 | Ftsy-ng high-resolution | x-ray diffraction | A, B | GNP, NH4, GDP | — |
| P10121 | AlphaFold monomer V2.0 prediction for signal recognition particle receptor ftsy (P10121) | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 6 records
- K · Potassium ion · in 6 records
- MG · Magnesium ion · in 5 records
- NA · Sodium ion · in 5 records
- NH4 · Ammonium ion · in 4 records
- 4ME · methyl 1H-indole-4-carboxylate · in 2 records
- F9Y · 1H-indole-6-carbonitrile · in 2 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 2 records
- ALF · Tetrafluoroaluminate ion · in 1 record
- GCP · Phosphomethylphosphonic acid guanylate ester · in 1 record
Experiment against prediction
- 2QY9 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.57 Å
- 2QY9 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.57 Å
- 6NC1 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.68 Å
- 6NC1 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.68 Å
- 6CS8 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.70 Å
- 6CS8 chain A against the predicted model P10121: TM-score 0.99, RMSD 0.70 Å
- 6CVD chain A against the predicted model P10121: TM-score 0.99, RMSD 0.74 Å
- 6CVD chain A against the predicted model P10121: TM-score 0.99, RMSD 0.74 Å
- 6NC4 chain B against the predicted model P10121: TM-score 0.99, RMSD 0.90 Å
- 6CS8 chain B against the predicted model P10121: TM-score 0.99, RMSD 0.92 Å
Elsewhere
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