MolNFT v1 · #157833 · protein

Ftsy-ng high-resolution

6NC1 · Signal recognition particle receptor ftsy: “Ftsy-ng high-resolution”. X-ray diffraction, 3 ligands (GDP, K, MG), 3 pockets (best druggability 0.81). MolNFT v1 #157833 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NC1
Type: protein
Length: 604 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal recognition particle receptor ftsy
UniProt: P10121
Ligands: GDP, K, MG
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Signal recognition particle receptor ftsy	protein	301	53% helix, 13% strand	P10121
B	Signal recognition particle receptor ftsy	protein	303	55% helix, 13% strand	P10121

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
K · Potassium ion · metal · 4 copies · chains A, B
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	670	0.81	0.85	52	empty
2	50	0.31	0.77	21	empty
3	50	0.31	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 745 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6NC1 · FtsY-NG high-resolution · the same entry in another collection · chain A against A, TM-score 1.00
P10121 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor ftsy (P10121) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10121
Elsewhere: RCSB PDB 6NC1 · PDBe 6NC1 · UniProt P10121

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