UniProt P0AGG8
Metalloprotease TldD (P0AGG8)
Metalloprotease TldD (UniProt P0AGG8), EC 3.4.-.-: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 73 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AGG8
- Protein
- Metalloprotease TldD
- EC
- 3.4.-.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 73 · 5 records with a druggable one
Structures
13 records of P0AGG8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NJ5 | E. coli Microcin-processing metalloprotease TldD/E with phosphate bound | x-ray diffraction | A, C | ZN, PO4 | — |
| 5NJ5 | E. COLI microcin-processing metalloprotease TLDD/E with phosphate bound | x-ray diffraction | A, C | ZN, PO4 | — |
| 5NJ9 | E. coli Microcin-processing metalloprotease TldD/E with DRVY angiotensin fragment bound | x-ray diffraction | A, C | ZN, NA | 17 (best 0.78) |
| 5NJ9 | E. COLI microcin-processing metalloprotease TLDD/E with drvy angiotensin fragment bound | x-ray diffraction | A, C | ZN, NA | — |
| 5NJA | E. coli Microcin-processing metalloprotease TldD/E with angiotensin analogue bound | x-ray diffraction | A, C | ZN, NA | 18 (best 0.79) |
| 5NJA | E. COLI microcin-processing metalloprotease TLDD/E with angiotensin analogue bound | x-ray diffraction | A, C | ZN, NA | — |
| 5NJB | E. coli Microcin-processing metalloprotease TldD/E with actinonin bound | x-ray diffraction | A, C | ZN, BB2 | 16 (best 0.74) |
| 5NJB | E. COLI microcin-processing metalloprotease TLDD/E with actinonin bound | x-ray diffraction | A, C | ZN, BB2 | — |
| 5NJC | E. coli Microcin-processing metalloprotease TldD/E (TldD E263A mutant) with hexapeptide bound | x-ray diffraction | A, C | ZN, NA | 17 (best 0.75) |
| 5NJC | E. COLI microcin-processing metalloprotease TLDD/E (tldd E263A mutant) with hexapeptide bound | x-ray diffraction | A, C | ZN, NA | — |
| 5NJF | E. coli Microcin-processing metalloprotease TldD/E (TldD H262A mutant) with pentapeptide bound | x-ray diffraction | A, C | ZN, NA | — |
| 5NJF | E. COLI microcin-processing metalloprotease TLDD/E (tldd H262A mutant) with pentapeptide bound | x-ray diffraction | A, C | ZN, NA | — |
| P0AGG8 | AlphaFold monomer V2.0 prediction for metalloprotease tldd (P0AGG8) | predicted | A | — | 5 (best 0.56) |
Ligands
Experiment against prediction
- 5NJB chain C against the predicted model P0AGG8: TM-score 1.00, RMSD 0.17 Å
- 5NJB chain C against the predicted model P0AGG8: TM-score 1.00, RMSD 0.17 Å
- 5NJA chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.19 Å
- 5NJA chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.19 Å
- 5NJ9 chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.19 Å
- 5NJ9 chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.19 Å
- 5NJB chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.20 Å
- 5NJB chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.20 Å
- 5NJ5 chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.23 Å
- 5NJ5 chain A against the predicted model P0AGG8: TM-score 1.00, RMSD 0.23 Å
Elsewhere
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