UniProt P0ACT4
Tetracycline repressor protein class D (P0ACT4)
Tetracycline repressor protein class D (UniProt P0ACT4): 85 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0ACT4
- Protein
- Tetracycline repressor protein class D
- Experimental structures
- 85
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 14 · 6 records with a druggable one
Structures
86 records of P0ACT4 in the MolNFT archive: 85 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A6I | Tet repressor, class D variant | x-ray diffraction | A | — | — |
| 1A6I | Tet repressor, class D variant | x-ray diffraction | A | — | — |
| 1BJZ | Tetracycline chelated MG2+-ion initiates helix unwinding for tet repressor induction | x-ray diffraction | A | — | — |
| 1BJZ | Tetracycline chelated MG2+-ion initiates helix unwinding for tet repressor induction | x-ray diffraction | A | — | — |
| 1ORK | Tet repressor, class D in complex with 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline | x-ray diffraction | A | — | — |
| 1ORK | Tet repressor, class D in complex with 9-(N,N-dimethylglycylamido)-6- demethyl-6-deoxy-tetracycline | x-ray diffraction | A | — | — |
| 1QPI | Crystal structure of tetracycline REPRESSOR/OPERATOR complex | x-ray diffraction | A | — | — |
| 1QPI | Crystal structure of tetracycline REPRESSOR/OPERATOR complex | x-ray diffraction | A | — | — |
| 2FJ1 | Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II) | x-ray diffraction | A | — | — |
| 2FJ1 | Crystal structure analysis of tet repressor (class D) in complex with 7-chlortetracycline-NICKEL(II) | x-ray diffraction | A | — | — |
| 2NS7 | How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | x-ray diffraction | A, B, C, D | — | — |
| 2NS7 | How an in vitro selected peptide mimics the antibiotic tetracycline to induce tet repressor | x-ray diffraction | A, B, C, D | — | — |
| 2NS8 | How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | x-ray diffraction | A, B, C, D | — | — |
| 2NS8 | How an in vitro selected peptide mimics the antibiotic tetracycline to induce tet repressor | x-ray diffraction | A, B, C, D | — | — |
| 2O7O | Crystal structure analysis of TetR(D) complex with doxycycline | x-ray diffraction | A | — | — |
| 2O7O | Crystal structure analysis of TETR(D) complex with doxycycline | x-ray diffraction | A | — | — |
| 2TCT | The complex formed between tet repressor and tetracycline-MG2+ reveals mechanism of antibiotic… | x-ray diffraction | A | — | — |
| 2TCT | The complex formed between tet repressor and tetracycline-MG2+ reveals mechanism of antibiotic… | x-ray diffraction | A | — | — |
| 2TRT | Tetracycline repressor class D | x-ray diffraction | A | — | — |
| 2TRT | Tetracycline repressor class D | x-ray diffraction | A | — | — |
| 2VKE | Tet repressor class D complexed with cobalt and tetracycline | x-ray diffraction | A | — | — |
| 2VKE | Tet repressor class D complexed with cobalt and tetracycline | x-ray diffraction | A | — | — |
| 2VKV | TetR (BD) variant L17G with reverse phenotype | x-ray diffraction | A | — | — |
| 2VKV | Tetr (bd) variant L17G with reverse phenotype | x-ray diffraction | A | — | — |
| 2X6O | Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline | x-ray diffraction | A | — | — |
| 2X6O | Tet repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline | x-ray diffraction | A | — | — |
| 2X9D | Tet repressor (class D) in complex with iso-7-chlortetracycline | x-ray diffraction | A | — | — |
| 2X9D | Tet repressor (class D) in complex with iso-7-chlortetracycline | x-ray diffraction | A | — | — |
| 2XB5 | Tet repressor (class D) in complex with 7-Iodotetracycline | x-ray diffraction | A | — | — |
| 2XB5 | Tet repressor (class D) in complex with 7-iodotetracycline | x-ray diffraction | A | — | — |
| 2XGC | Crystal structure of a designed heterodimeric variant T-A(I)B of the tetracycline repressor | x-ray diffraction | A, B | — | — |
| 2XGC | Crystal structure of a designed heterodimeric variant T-A(I) B of the tetracycline repressor | x-ray diffraction | A, B | — | — |
| 2XGD | Crystal structure of a designed homodimeric variant T-A(L)A(L) of the tetracycline repressor | x-ray diffraction | A | — | — |
| 2XGD | Crystal structure of a designed homodimeric variant T-A(L)A( L) of the tetracycline repressor | x-ray diffraction | A | — | — |
| 2XGE | Crystal structure of a designed heterodimeric variant T-A(A)B of the tetracycline repressor | x-ray diffraction | A, B | — | — |
| 2XGE | Crystal structure of a designed heterodimeric variant T-A(A) B of the tetracycline repressor | x-ray diffraction | A, B | — | — |
| 2XPU | TetR(D) in complex with anhydrotetracycline. | x-ray diffraction | A | — | — |
| 2XPU | TETR(D) in complex with anhydrotetracycline. | x-ray diffraction | A | — | — |
| 2XPV | TetR(D) in complex with minocycline and magnesium. | x-ray diffraction | A | — | — |
| 2XPV | TETR(D) in complex with minocycline and magnesium. | x-ray diffraction | A | — | — |
| 2XPW | TetR(D) in complex with oxytetracycline and magnesium. | x-ray diffraction | A | — | — |
| 2XPW | TETR(D) in complex with oxytetracycline and magnesium. | x-ray diffraction | A | — | — |
| 2XRL | Tet-repressor class D T103A with doxycycline | x-ray diffraction | A | — | — |
| 2XRL | Tet-repressor class D T103A with doxycycline | x-ray diffraction | A | — | — |
| 3FK6 | Crystal structure of TetR triple mutant (H64K, S135L, S138I) | x-ray diffraction | A, B | — | — |
| 3FK6 | Crystal structure of tetr triple mutant (H64K, S135L, S138I) | x-ray diffraction | A, B | — | — |
| 3FK7 | Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc | x-ray diffraction | A, B | — | — |
| 3FK7 | Crystal structure of tetr triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc | x-ray diffraction | A, B | — | — |
| 3ZQF | Structure of Tetracycline repressor in complex with antiinducer peptide-TAP1 | x-ray diffraction | A | — | — |
| 3ZQF | Structure of tetracycline repressor in complex with antiinducer peptide-TAP1 | x-ray diffraction | A | — | — |
| 3ZQG | Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2 | x-ray diffraction | A | — | — |
| 3ZQG | Structure of tetracycline repressor in complex with antiinducer peptide-TAP2 | x-ray diffraction | A | — | — |
| 3ZQH | Structure of Tetracycline repressor in complex with inducer peptide- TIP3 | x-ray diffraction | A | — | — |
| 3ZQH | Structure of tetracycline repressor in complex with inducer peptide- TIP3 | x-ray diffraction | A | — | — |
| 3ZQI | Structure of Tetracycline repressor in complex with inducer peptide- TIP2 | x-ray diffraction | A, B | — | — |
| 3ZQI | Structure of tetracycline repressor in complex with inducer peptide- TIP2 | x-ray diffraction | A, B | — | — |
| 4ABZ | TetR(D) in Complex with Tigecycline and Magnesium, co-crystallized | x-ray diffraction | AAA | — | — |
| 4AUX | Tet repressor class D in complex with 9-nitrotetracycline | x-ray diffraction | A | — | — |
| 4AUX | Tet repressor class D in complex with 9-nitrotetracycline | x-ray diffraction | A | — | — |
| 4B1R | Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline | x-ray diffraction | A | — | — |
26 records more on the page itself.
Ligands
- CL · Chloride ion · in 16 records
- MG · Magnesium ion · in 15 records
- DXT · (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-3,5,10,12,12A-pentahydroxy-6-methyl-1,11-dioxo-1,4,4A,5,5A,6,11,12A-octahydrotetracene-2-carboxamide · in 6 records
- MIY · (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12A-tetrahydroxy-1,11-dioxo-1,4,4A,5,5A,6,11,12A-octahydrotetracene-2-carboxamide · in 3 records
- TAC · Tetracycline · in 3 records
- T1C · Tigecycline · in 2 records
- CTC · 7-chlorotetracycline · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 3FK7 chain B against the predicted model P0ACT4: TM-score 0.97, RMSD 0.89 Å
- 3FK7 chain B against the predicted model P0ACT4: TM-score 0.97, RMSD 0.89 Å
- 3FK7 chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 0.96 Å
- 3FK7 chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 0.96 Å
- 3FK6 chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 0.89 Å
- 3FK6 chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 0.89 Å
- 2TRT chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 1.02 Å
- 2TRT chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 1.02 Å
- 1ORK chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 1.02 Å
- 1ORK chain A against the predicted model P0ACT4: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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