UniProt P0ABQ5
P0ABQ5
P0ABQ5 (UniProt P0ABQ5): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0ABQ5
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
Structures
9 records of P0ABQ5 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CC9 | L28F E.COLI dihydrofolate reductase complexed with 5,10- dideazatetrahydrofolate and oxidized… | x-ray diffraction | A | — | — |
| 5CCC | Wild-type E.COLI dihydrofolate reductase complexed with 5,10- dideazatetrahydrofolate and oxidized… | x-ray diffraction | A | — | — |
| 6CW7 | E. coli DHFR product complex with (6S)-5,6,7,8-TETRAHYDROFOLATE | x-ray diffraction | A | CL, MG | — |
| 6CW7 | E. COLI DHFR product complex with (6S)-5,6,7,8-tetrahydrofolate | x-ray diffraction | A | CL, MG | — |
| 6CXK | E. coli DHFR substrate complex with Dihydrofolate | x-ray diffraction | A | MG, CL | — |
| 6CXK | E. COLI DHFR substrate complex with dihydrofolate | x-ray diffraction | A | MG, CL | — |
| 6CYV | E. COLI DHFR ternary complex with NADP and dihydrofolate | x-ray diffraction | A | NAP | — |
| 7MYM | Crystal structure of escherichia COLI dihydrofolate reductase in complex with trimethoprim and NADPH | x-ray diffraction | A, C, B | NAP, TOP, SO4 | — |
| P0ABQ5 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P0ABQ5) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7MYM chain B against the predicted model P0ABQ5: TM-score 0.99, RMSD 0.38 Å
- 7MYM chain A against the predicted model P0ABQ5: TM-score 0.99, RMSD 0.42 Å
- 7MYM chain C against the predicted model P0ABQ5: TM-score 0.99, RMSD 0.43 Å
- 6CW7 chain A against the predicted model P0ABQ5: TM-score 0.95, RMSD 1.25 Å
- 6CW7 chain A against the predicted model P0ABQ5: TM-score 0.95, RMSD 1.25 Å
- 5CCC chain A against the predicted model P0ABQ5: TM-score 0.96, RMSD 1.14 Å
- 5CC9 chain A against the predicted model P0ABQ5: TM-score 0.96, RMSD 1.14 Å
- 6CXK chain A against the predicted model P0ABQ5: TM-score 0.93, RMSD 1.30 Å
- 6CXK chain A against the predicted model P0ABQ5: TM-score 0.93, RMSD 1.30 Å
- 6CYV chain A against the predicted model P0ABQ5: TM-score 0.97, RMSD 0.61 Å
Elsewhere
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