UniProt P0ABP8

Purine nucleoside phosphorylase (P0ABP8)

Purine nucleoside phosphorylase (UniProt P0ABP8), EC 2.4.2.1: 30 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 244 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P0ABP8
Protein: Purine nucleoside phosphorylase
EC: 2.4.2.1
Experimental structures: 30
Predicted models: 1
Ligands: 12
Pockets: 244 · 30 records with a druggable one

Structures

31 records of P0ABP8 in the MolNFT archive: 30 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1A69	Purine nucleoside phosphorylase in complex with formycin B and sulphate (phosphate)	x-ray diffraction	A, B, C	SO4, FMB	7 (best 0.68)
1A69	Purine nucleoside phosphorylase in complex with formycin B and sulphate (phosphate)	x-ray diffraction	A, B, C	SO4, FMB	7 (best 0.68)
1ECP	Purine nucleoside phosphorylase	x-ray diffraction	A, B, C, D, E, F	—	13 (best 0.81)
1ECP	Purine nucleoside phosphorylase	x-ray diffraction	A, B, C, D, E, F	—	13 (best 0.81)
1K9S	Purine nucleoside phosphorylase from E. COLI in complex with formycin a derivative and phosphate	x-ray diffraction	A, B, C, D, E, F	PO4, FM2, FM1	12 (best 0.84)
1K9S	Purine nucleoside phosphorylase from E. COLI in complex with formycin a derivative and phosphate	x-ray diffraction	A, B, C, D, E, F	PO4, FM2, FM1	12 (best 0.84)
1OTX	Purine Nucleoside Phosphorylase M64V mutant	x-ray diffraction	A, B, C	PO4	7 (best 0.65)
1OTX	Purine nucleoside phosphorylase M64V mutant	x-ray diffraction	A, B, C	PO4	7 (best 0.65)
1OTY	Native PNP +ALLO	x-ray diffraction	A, B, C	PO4, 6MP	7 (best 0.65)
1OTY	Native pnp +allo	x-ray diffraction	A, B, C	PO4, 6MP	7 (best 0.65)
1OU4	Native PNP +Talo	x-ray diffraction	A, B, C	PO4, 6MP	7 (best 0.65)
1OU4	Native pnp +talo	x-ray diffraction	A, B, C	PO4, 6MP	7 (best 0.65)
1OUM	M64V PNP +Talo	x-ray diffraction	A, B, C	TAL, PO4	8 (best 0.57)
1OUM	M64V pnp +talo	x-ray diffraction	A, B, C	TAL, PO4	8 (best 0.57)
1OV6	M64V pnp + allo	x-ray diffraction	A, B, C	PO4, DBM	7 (best 0.64)
1OV6	M64V pnp + allo	x-ray diffraction	A, B, C	PO4, DBM	7 (best 0.64)
1OVG	M64V PNP +MePdr	x-ray diffraction	A, B, C	PO4, MDR	7 (best 0.61)
1OVG	M64V pnp +mepdr	x-ray diffraction	A, B, C	PO4, MDR	7 (best 0.61)
3UT6	Crystal structure of E. Coli PNP complexed with PO4 and formycin A	x-ray diffraction	A, B, C	FMC, PO4	6 (best 0.67)
3UT6	Crystal structure of E. COLI pnp complexed with PO4 and formycin a	x-ray diffraction	A, B, C	FMC, PO4	6 (best 0.67)
4TTI	Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 4 FMC molecules	x-ray diffraction	A, B, C, D, E, F	FMC, PO4, SO4	12 (best 0.79)
4TTI	Crystal structure of double mutant E. COLI purine nucleoside phosphorylase with 4 fmc molecules	x-ray diffraction	A, B, C, D, E, F	FMC, PO4, SO4	12 (best 0.79)
4TTJ	Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 6 FMC molecules	x-ray diffraction	A, B, D	PO4, FMC, SO4	7 (best 0.71)
4TTJ	Crystal structure of double mutant E. COLI purine nucleoside phosphorylase with 6 fmc molecules	x-ray diffraction	A, B, D	PO4, FMC, SO4	7 (best 0.71)
5IU6	Crystal structure of E.coli purine nucleoside phosphorylase with 7-deazahypoxanthine	x-ray diffraction	A, B, C	7HX, SO4	7 (best 0.62)
5IU6	Crystal structure of E.COLI purine nucleoside phosphorylase with 7- deazahypoxanthine	x-ray diffraction	A, B, C	7HX, SO4	7 (best 0.62)
6XZ2	Crystal structure of E. Coli purine nucleoside phosphorylase mutant Y160W with SO4 and Formycin A	x-ray diffraction	A, B, C	SO4, FMC	8 (best 0.70)
6XZ2	Crystal structure of E. COLI purine nucleoside phosphorylase mutant Y160W with SO4 and formycin a	x-ray diffraction	A, B, C	SO4, FMC	8 (best 0.70)
9FPE	Wild type Purine Nucleoside Phosphorylase from E.coli in complex with N2,3-etheno-2-aminopurine	x-ray diffraction	A, B, C	A1IEC, PO4, SO4	7 (best 0.67)
9FXE	D204N mutant of Purine Nucleoside Phosphorylase from E.coli in complex with…	x-ray diffraction	A, C, B	PO4, A1IEC	7 (best 0.67)
P0ABP8	AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase deod-type (P0ABP8)	predicted	A	—	—

Ligands

PO4 · Phosphate ion · in 22 records
SO4 · Sulfate ion · in 11 records
FMC · (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol · in 8 records
6MP · 6-methylpurine · in 4 records
7HX · 7H-pyrrolo[2,3-d]pyrimidin-4-ol · in 2 records
A1IEC · N,2,3-etheno-2-aminopurine · in 2 records
DBM · 9-(6-deoxy-beta-D-allofuranosyl)-6-methylpurine · in 2 records
FM1 · 2-hydroxymethyl-5-(7-methylamino-3H-pyrazolo[4,3-d]pyrimidin-3-yl)-tetrahydro-furan-3,4-diol · in 2 records
FM2 · 2-(7-amino-6-methyl-3H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol · in 2 records
FMB · Formycin B · in 2 records
MDR · 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine · in 2 records
TAL · 9-(6-deoxy-alpha-L-talofuranosyl)-6-methylpurine · in 2 records

Experiment against prediction

9FXE chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.26 Å
4TTJ chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.27 Å
4TTJ chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.27 Å
3UT6 chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.29 Å
3UT6 chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.29 Å
9FPE chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.30 Å
1K9S chain C against the predicted model P0ABP8: TM-score 1.00, RMSD 0.30 Å
1K9S chain C against the predicted model P0ABP8: TM-score 1.00, RMSD 0.30 Å
4TTI chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.30 Å
4TTI chain A against the predicted model P0ABP8: TM-score 1.00, RMSD 0.30 Å

Elsewhere

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