UniProt P0A8T8
DNA-directed RNA polymerase subunit beta' (P0A8T8)
DNA-directed RNA polymerase subunit beta' (UniProt P0A8T8), EC 2.7.7.6: 82 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 520 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A8T8
- Protein
- DNA-directed RNA polymerase subunit beta'
- EC
- 2.7.7.6
- Experimental structures
- 82
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 520 · 53 records with a druggable one
Structures
83 records of P0A8T8 in the MolNFT archive: 82 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YG2 | X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme | x-ray diffraction | D, J | MG, ZN | 12 (best 0.84) |
| 4YG2 | X-ray crystal structur of escherichia COLI RNA polymerase SIGMA70 holoenzyme | x-ray diffraction | D, J | MG, ZN | 12 (best 0.84) |
| 5EZK | RNA polymerase model placed by Molecular replacement into X-ray diffraction map of DNA-bound RNA… | x-ray diffraction | D | — | 11 (best 0.88) |
| 5EZK | RNA polymerase model placed by molecular replacement into X-ray diffraction MAP of DNA-bound RNA… | x-ray diffraction | D | — | 11 (best 0.88) |
| 5TBZ | E. COLI RNA polymerase complexed with nusg | x-ray diffraction | D, I | — | — |
| 5UI8 | structure of sigmaN-holoenzyme | x-ray diffraction | J | MG, ZN | 10 (best 0.83) |
| 5UI8 | Structure of sigman-holoenzyme | x-ray diffraction | J | MG, ZN | — |
| 6AWB | Structure of 30S ribosomal subunit and RNA polymerase complex in non-rotated state | electron microscopy | 04 | — | 2 (best 0.85) |
| 6AWC | Structure of 30S ribosomal subunit and RNA polymerase complex in rotated state | electron microscopy | 04 | — | 3 (best 0.83) |
| 6AWD | Structure of 30S (S1 depleted) ribosomal subunit and RNA polymerase complex | electron microscopy | 04 | — | 2 (best 0.80) |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | D | ZN, MG | 13 (best 0.83) |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | D | ZN, MG | — |
| 6GOV | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | electron microscopy | Y | MG, ZN | 12 (best 0.86) |
| 6GOV | Structure of the RNA polymerase lambda-based antitermination complex | electron microscopy | Y | MG, ZN | — |
| 6N62 | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | D | MG, ZN | 12 (best 0.81) |
| 6N62 | Escherichia COLI RNA polymerase SIGMA70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | D | MG, ZN | — |
| 6PB4 | The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | D | ZN, MG | 13 (best 0.88) |
| 6PB4 | The E. COLI class-II cap-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | D | ZN, MG | — |
| 6PB5 | The E. coli class-II CAP-dependent transcription activation complex at the state 1 architecture | electron microscopy | D | ZN, MG | 10 (best 0.88) |
| 6PB5 | The E. COLI class-II cap-dependent transcription activation complex at the state 1 architecture | electron microscopy | D | ZN, MG | — |
| 6PB6 | The E. coli class-II CAP-dependent transcription activation complex at the state 2 | electron microscopy | D | ZN, MG | 14 (best 0.90) |
| 6PB6 | The E. COLI class-II cap-dependent transcription activation complex at the state 2 | electron microscopy | D | ZN, MG | — |
| 6PMI | Sigm28-transcription initiation complex with specific promoter at the state 1 | electron microscopy | D | ZN, MG | 12 (best 0.87) |
| 6PMI | SIGM28-transcription initiation complex with specific promoter at the state 1 | electron microscopy | D | ZN, MG | — |
| 6PMJ | Sigm28-transcription initiation complex with specific promoter at the state 2 | electron microscopy | D | ZN, MG | 13 (best 0.86) |
| 6PMJ | SIGM28-transcription initiation complex with specific promoter at the state 2 | electron microscopy | D | ZN, MG | — |
| 6XH7 | CueR-TAC without RNA | electron microscopy | D | ZN | 15 (best 0.84) |
| 6XH7 | Cuer-tac without RNA | electron microscopy | D | ZN | — |
| 6XH8 | CueR-transcription activation complex with RNA transcript | electron microscopy | D | ZN | 13 (best 0.84) |
| 6XH8 | Cuer-transcription activation complex with RNA transcript | electron microscopy | D | ZN | — |
| 6XL5 | Cryo-EM structure of EcmrR-RNAP-promoter open complex (EcmrR-RPo) | electron microscopy | D | MG, ZN, 1N7 | 8 (best 0.85) |
| 6XL5 | Cryo-EM structure of ecmrr-rnap-promoter open complex (ecmrr-rpo) | electron microscopy | D | MG, ZN | — |
| 6XL9 | Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 3-nt RNA transcript… | electron microscopy | D | ZN, MG | 10 (best 0.86) |
| 6XL9 | Cryo-EM structure of ecmrr-rnap-promoter initial transcribing complex with 3-nt RNA transcript… | electron microscopy | D | ZN, MG | — |
| 6XLJ | Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 4-nt RNA transcript… | electron microscopy | D | 118, MG, ZN, 1N7 | 12 (best 0.81) |
| 6XLJ | Cryo-EM structure of ecmrr-rnap-promoter initial transcribing complex with 4-nt RNA transcript… | electron microscopy | D | 118, MG, ZN, 1N7 | — |
| 6XLL | Cryo-EM structure of E. coli RNAP-promoter initial transcribing complex with 5-nt RNA transcript… | electron microscopy | D | MG, ZN | 13 (best 0.85) |
| 6XLL | Cryo-EM structure of E. COLI rnap-promoter initial transcribing complex with 5-nt RNA transcript… | electron microscopy | D | MG, ZN | — |
| 6XLM | Cryo-EM structure of E.coli RNAP-DNA elongation complex 1 (RDe1) in EcmrR-dependent transcription | electron microscopy | D | MG, ZN | 13 (best 0.84) |
| 6XLM | Cryo-EM structure of E.COLI rnap-DNA elongation complex 1 (RDE1) in ecmrr-dependent transcription | electron microscopy | D | MG, ZN | — |
| 6XLN | Cryo-EM structure of E. coli RNAP-DNA elongation complex 2 (RDe2) in EcmrR-dependent transcription | electron microscopy | D | MG, ZN | 13 (best 0.81) |
| 6XLN | Cryo-EM structure of E. COLI rnap-DNA elongation complex 2 (RDE2) in ecmrr-dependent transcription | electron microscopy | D | MG, ZN | — |
| 6ZTJ | E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA) | electron microscopy | CD | MG, ZN | 1 (best 0.84) |
| 6ZTL | E. coli 70S-RNAP expressome complex in collided state bound to NusG | electron microscopy | CD | MG, ZN | 2 (best 0.84) |
| 6ZTM | E. coli 70S-RNAP expressome complex in collided state without NusG | electron microscopy | CD | MG, ZN | 1 (best 0.83) |
| 6ZTN | E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA) | electron microscopy | CD | MG, ZN | 3 (best 0.83) |
| 6ZTO | E. coli 70S-RNAP expressome complex in uncoupled state 1 | electron microscopy | CD | MG, ZN | 2 (best 0.84) |
| 6ZTP | E. coli 70S-RNAP expressome complex in uncoupled state 6 | electron microscopy | CD | MG, ZN | 1 (best 0.83) |
| 6ZU1 | E. coli 70S-RNAP expressome complex in uncoupled state 2 | electron microscopy | CD | MG, ZN | 1 (best 0.83) |
| 7BEG | Structures of class I bacterial transcription complexes | electron microscopy | D | — | 13 (best 0.86) |
| 7BEG | Structures of class I bacterial transcription complexes | electron microscopy | D | — | — |
| 7PY0 | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusG (NusG-EC in… | electron microscopy | D | MG, ZN | 13 (best 0.85) |
| 7PY0 | Cryoem structure of E.COLI RNA polymerase elongation complex bound to nusg (nusg-ec in… | electron microscopy | D | MG, ZN | — |
| 7PY1 | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusG (the consensus NusG-EC) | electron microscopy | D | MG, ZN | 14 (best 0.82) |
| 7PY1 | Cryoem structure of E.COLI RNA polymerase elongation complex bound to nusg (the consensus nusg-ec) | electron microscopy | D | MG, ZN | — |
| 7PY3 | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (the consensus NusA-EC) | electron microscopy | D | MG, ZN | 11 (best 0.84) |
| 7PY3 | Cryoem structure of E.COLI RNA polymerase elongation complex bound to nusa (the consensus nusa-ec) | electron microscopy | D | MG, ZN | — |
| 7PY5 | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (the consensus… | electron microscopy | D | MG, ZN | 12 (best 0.85) |
| 7PY5 | Cryoem structure of E.COLI RNA polymerase elongation complex bound to nusa and nusg (the consensus… | electron microscopy | D | MG, ZN | — |
| 7PY6 | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG… | electron microscopy | D | MG, ZN | 10 (best 0.85) |
23 records more on the page itself.
Ligands
Experiment against prediction
- 4YG2 chain J against the predicted model P0A8T8: TM-score 0.98, RMSD 1.50 Å
- 4YG2 chain J against the predicted model P0A8T8: TM-score 0.98, RMSD 1.50 Å
- 4YG2 chain D against the predicted model P0A8T8: TM-score 0.97, RMSD 1.87 Å
- 4YG2 chain D against the predicted model P0A8T8: TM-score 0.97, RMSD 1.87 Å
- 6N62 chain D against the predicted model P0A8T8: TM-score 0.97, RMSD 2.10 Å
- 6N62 chain D against the predicted model P0A8T8: TM-score 0.97, RMSD 2.10 Å
- 5EZK chain D against the predicted model P0A8T8: TM-score 0.96, RMSD 2.01 Å
- 5EZK chain D against the predicted model P0A8T8: TM-score 0.96, RMSD 2.01 Å
- 6ZTL chain CD against the predicted model P0A8T8: TM-score 0.94, RMSD 3.35 Å
- 6ZTM chain CD against the predicted model P0A8T8: TM-score 0.94, RMSD 3.37 Å
Elsewhere
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