UniProt P0A7A9
Inorganic pyrophosphatase (P0A7A9)
Inorganic pyrophosphatase (UniProt P0A7A9), EC 3.6.1.1: 38 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A7A9
- Protein
- Inorganic pyrophosphatase
- EC
- 3.6.1.1
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 11 · 4 records with a druggable one
Structures
39 records of P0A7A9 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FAJ | Inorganic pyrophosphatase | x-ray diffraction | A | — | 1 (best 0.48) |
| 1FAJ | Inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 1I40 | Structure of inorganic pyrophosphatase | x-ray diffraction | A | NA, CA, CL | 2 (best 0.63) |
| 1I40 | Structure of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 1I6T | Structure of inorganic pyrophosphatase | x-ray diffraction | A | CA, NA, CL, POP | 1 (best 0.55) |
| 1I6T | Structure of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 1IGP | X-ray crystallographic studies of recombinant inorganic pyrophosphatase from escherichia COLI | x-ray diffraction | A | — | 1 (best 0.48) |
| 1IGP | X-ray crystallographic studies of recombinant inorganic pyrophosphatase from escherichia COLI | x-ray diffraction | A | — | — |
| 1INO | Recombinant inorganic pyrophosphatase from escherichia COLI | x-ray diffraction | A | MN | 1 (best 0.55) |
| 1INO | Recombinant inorganic pyrophosphatase from escherichia COLI | x-ray diffraction | A | — | — |
| 1IPW | Inorganic pyrophosphatase from escherichia COLI with three magnesium ions | x-ray diffraction | A, B | MG | 5 (best 0.54) |
| 1IPW | Inorganic pyrophosphatase from escherichia COLI with three magnesium ions | x-ray diffraction | A, B | — | — |
| 1JFD | Structure of inorganic pyrophosphatase | x-ray diffraction | A, B | — | — |
| 1JFD | Structure of inorganic pyrophosphatase | x-ray diffraction | A, B | — | — |
| 1MJW | Structure of inorganic pyrophosphatase mutant D42N | x-ray diffraction | A, B | — | — |
| 1MJW | Structure of inorganic pyrophosphatase mutant D42N | x-ray diffraction | A, B | — | — |
| 1MJX | Structure of inorganic pyrophosphatase mutant D65N | x-ray diffraction | A, B | — | — |
| 1MJX | Structure of inorganic pyrophosphatase mutant D65N | x-ray diffraction | A, B | — | — |
| 1MJY | Structure of inorganic pyrophosphatase mutant D70N | x-ray diffraction | A, B | — | — |
| 1MJY | Structure of inorganic pyrophosphatase mutant D70N | x-ray diffraction | A, B | — | — |
| 1MJZ | Structure of inorganic pyrophosphatase mutant D97N | x-ray diffraction | A | — | — |
| 1MJZ | Structure of inorganic pyrophosphatase mutant D97N | x-ray diffraction | A | — | — |
| 1OBW | Structure of inorganic pyrophosphatase | x-ray diffraction | A, B, C | — | — |
| 1OBW | Structure of inorganic pyrophosphatase | x-ray diffraction | A, B, C | — | — |
| 2AU6 | Crystal structure of catalytic intermediate of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU6 | Crystal structure of catalytic intermediate of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU7 | The R43Q active site variant of E.coli inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU7 | The R43Q active site variant of E.COLI inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU8 | Catalytic intermediate structure of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU8 | Catalytic intermediate structure of inorganic pyrophosphatase | x-ray diffraction | A | — | — |
| 2AU9 | Inorganic pyrophosphatase complexed with substrate | x-ray diffraction | A | — | — |
| 2AU9 | Inorganic pyrophosphatase complexed with substrate | x-ray diffraction | A | — | — |
| 2AUU | Inorganic pyrophosphatase complexed with magnesium pyrophosphate and fluoride | x-ray diffraction | A | — | — |
| 2AUU | Inorganic pyrophosphatase complexed with magnesium pyrophosphate and fluoride | x-ray diffraction | A | — | — |
| 2EIP | Inorganic pyrophosphatase | x-ray diffraction | A, B | — | — |
| 2EIP | Inorganic pyrophosphatase | x-ray diffraction | A, B | — | — |
| 4UM4 | Structure of inorganic pyrophosphatase from escherichia COLI in complex with sulfate | x-ray diffraction | A, B, C | — | — |
| 4UM4 | Structure of inorganic pyrophosphatase from escherichia COLI in complex with sulfate | x-ray diffraction | A, B, C | — | — |
| P0A7A9 | AlphaFold monomer V2.0 prediction for inorganic pyrophosphatase (P0A7A9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1IPW chain B against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1IPW chain B against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1IPW chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1IPW chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1FAJ chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1FAJ chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.44 Å
- 1MJW chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.47 Å
- 1MJW chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.47 Å
- 2EIP chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.51 Å
- 2EIP chain A against the predicted model P0A7A9: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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