UniProt P0A6I0
Cytidylate kinase (P0A6I0)
Cytidylate kinase (UniProt P0A6I0), EC 2.7.4.14: 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A6I0
- Protein
- Cytidylate kinase
- EC
- 2.7.4.14
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 36 · 17 records with a druggable one
Structures
17 records of P0A6I0 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CKE | Cmp kinase from escherichia COLI free enzyme structure | x-ray diffraction | A | SO4 | 2 (best 0.62) |
| 1CKE | Cmp kinase from escherichia COLI free enzyme structure | x-ray diffraction | A | SO4 | 2 (best 0.62) |
| 1KDO | Cytidine monophosphate kinase from E. COLI in complex with cytidine monophosphate | x-ray diffraction | A, B | SO4, C5P | 2 (best 0.70) |
| 1KDO | Cytidine monophosphate kinase from E. COLI in complex with cytidine monophosphate | x-ray diffraction | A, B | SO4, C | 2 (best 0.70) |
| 1KDP | Cytidine monophosphate kinase from E. COLI in complex with 2'-deoxy-cytidine monophosphate | x-ray diffraction | A, B | SO4, DCM | 4 (best 0.73) |
| 1KDP | Cytidine monophosphate kinase from E. COLI in complex with 2'-deoxy-cytidine monophosphate | x-ray diffraction | A, B | SO4, C | 4 (best 0.73) |
| 1KDR | Cytidine monophosphate kinase from E.COLI in complex with ara-cytidine monophosphate | x-ray diffraction | A, B | SO4, CAR | 3 (best 0.74) |
| 1KDR | Cytidine monophosphate kinase from E.COLI in complex with ara-cytidine monophosphate | x-ray diffraction | A, B | SO4, CAR | 3 (best 0.74) |
| 1KDT | Cytidine monophosphate kinase from E.COLI in complex with 2',3'-dideoxy-cytidine monophosphate | x-ray diffraction | A, B | SO4, DOC | 2 (best 0.75) |
| 1KDT | Cytidine monophosphate kinase from E.COLI in complex with 2',3'-dideoxy-cytidine monophosphate | x-ray diffraction | A, B | SO4, DOC | 2 (best 0.75) |
| 2CMK | Cytidine monophosphate kinase in complex with cytidine-di-phosphate | x-ray diffraction | A | SO4, CDP | 2 (best 0.71) |
| 2CMK | Cytidine monophosphate kinase in complex with cytidine-di- phosphate | x-ray diffraction | A | SO4, CDP | 2 (best 0.71) |
| 2FEM | Mutant R188M of the Cytidine Monophosphate Kinase From E. Coli | x-ray diffraction | A | — | 1 (best 0.62) |
| 2FEM | Mutant R188M of the cytidine monophosphate kinase from E. COLI | x-ray diffraction | A | — | 1 (best 0.62) |
| 2FEO | Mutant R188M of The Cytidine Monophosphate Kinase from E. coli complexed with dCMP | x-ray diffraction | A | SO4, DC | 1 (best 0.75) |
| 2FEO | Mutant R188M of the cytidine monophosphate kinase from E. COLI complexed with dcmp | x-ray diffraction | A | SO4, DC | 1 (best 0.75) |
| P0A6I0 | AlphaFold monomer V2.0 prediction for cytidylate kinase (P0A6I0) | predicted | A | — | 2 (best 0.69) |
Ligands
- SO4 · Sulfate ion · in 14 records
- C · Cytidine-5'-monophosphate · in 2 records
- CAR · Cytosine arabinose-5'-phosphate · in 2 records
- CDP · Cytidine-5'-diphosphate · in 2 records
- DC · 2'-deoxycytidine-5'-monophosphate · in 2 records
- DOC · 2',3'-dideoxycytidine-5'-monophosphate · in 2 records
- C5P · Cytidine-5'-monophosphate · in 1 record
- DCM · 2'-deoxycytidine-5'-monophosphate · in 1 record
Experiment against prediction
- 1KDT chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.81 Å
- 1KDT chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.81 Å
- 2CMK chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.86 Å
- 2CMK chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.86 Å
- 1KDP chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.98 Å
- 1KDP chain A against the predicted model P0A6I0: TM-score 0.98, RMSD 0.98 Å
- 1KDO chain A against the predicted model P0A6I0: TM-score 0.97, RMSD 0.97 Å
- 1KDO chain A against the predicted model P0A6I0: TM-score 0.97, RMSD 0.97 Å
- 1KDR chain A against the predicted model P0A6I0: TM-score 0.97, RMSD 1.00 Å
- 1KDR chain A against the predicted model P0A6I0: TM-score 0.97, RMSD 1.00 Å
Elsewhere
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