UniProt P0A0Z8
Cmp-N-acetylneuraminic acid synthetase (P0A0Z8)
Cmp-N-acetylneuraminic acid synthetase (UniProt P0A0Z8), EC 2.7.7.43: 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A0Z8
- Protein
- Cmp-N-acetylneuraminic acid synthetase
- EC
- 2.7.7.43
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 17 · 8 records with a druggable one
Structures
13 records of P0A0Z8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EYR | Structure of a sialic acid activating synthetase, CMP acylneuraminate synthetase in the presence… | x-ray diffraction | A, B | CDP | 2 (best 0.67) |
| 1EYR | Structure of a sialic acid activating synthetase, cmp acylneuraminate synthetase in the presence… | x-ray diffraction | A, B | CDP | 2 (best 0.67) |
| 1EZI | Structure of a sialic acid activating synthetase, CMP acylneuraminate synthetase in the presence… | x-ray diffraction | A, B | — | 1 (best 0.70) |
| 1EZI | Structure of a sialic acid activating synthetase, cmp acylneuraminate synthetase in the presence… | x-ray diffraction | A, B | — | 1 (best 0.70) |
| 6CKJ | N. meningitidis CMP-sialic acid synthetase, ligand-free | x-ray diffraction | A | CA | 1 (best 0.53) |
| 6CKJ | N. meningitidis cmp-sialic acid synthetase, ligand-free | x-ray diffraction | A | CA | — |
| 6CKK | N. meningitidis CMP-sialic acid synthetase in the presence of CTP and Ca2+ | x-ray diffraction | A, B | CTP, CA | 3 (best 0.71) |
| 6CKK | N. meningitidis cmp-sialic acid synthetase in the presence of CTP and CA2+ | x-ray diffraction | A, B | CTP, CA | — |
| 6CKL | N. meningitidis CMP-sialic acid synthetase in the presence of CMP and Neu5Ac2en | x-ray diffraction | A, B, C | C5P, CL, DAN | 5 (best 0.88) |
| 6CKL | N. meningitidis cmp-sialic acid synthetase in the presence of cmp and NEU5AC2EN | x-ray diffraction | A, B, C | C5P, CL, DAN | — |
| 6CKM | N. meningitidis CMP-sialic acid synthetase in the presence of CMP-sialic acid and Ca2+ | x-ray diffraction | A | NCC, CA | 1 (best 0.50) |
| 6CKM | N. meningitidis cmp-sialic acid synthetase in the presence of cmp- sialic acid and CA2+ | x-ray diffraction | A | NCC, CA | — |
| P0A0Z8 | AlphaFold monomer V2.0 prediction for N-acylneuraminate cytidylyltransferase (P0A0Z8) | predicted | A | — | 1 (best 0.53) |
Ligands
- CA · Calcium ion · in 6 records
- C5P · Cytidine-5'-monophosphate · in 2 records
- CDP · Cytidine-5'-diphosphate · in 2 records
- CL · Chloride ion · in 2 records
- CTP · Cytidine-5'-triphosphate · in 2 records
- DAN · 2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid · in 2 records
- NCC · Cytidine-5'-monophosphate-5-N-acetylneuraminic acid · in 2 records
Experiment against prediction
- 1EYR chain B against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.01 Å
- 1EYR chain B against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.01 Å
- 6CKJ chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.07 Å
- 6CKJ chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.07 Å
- 6CKM chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.09 Å
- 6CKM chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.09 Å
- 1EYR chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.08 Å
- 1EYR chain A against the predicted model P0A0Z8: TM-score 0.97, RMSD 1.08 Å
- 1EZI chain A against the predicted model P0A0Z8: TM-score 0.96, RMSD 1.18 Å
- 1EZI chain A against the predicted model P0A0Z8: TM-score 0.96, RMSD 1.18 Å
Elsewhere
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