UniProt P09104
Gamma-enolase (P09104)
Gamma-enolase (UniProt P09104), EC 4.2.1.11: 30 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09104
- Protein
- Gamma-enolase
- EC
- 4.2.1.11
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 28 · 3 records with a druggable one
Structures
31 records of P09104 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TE6 | Crystal Structure of Human Neuron Specific Enolase at 1.8 angstrom | x-ray diffraction | A, B | — | — |
| 1TE6 | Crystal structure of human neuron specific enolase at 1.8 ångström | x-ray diffraction | A, B | — | — |
| 2AKM | Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex | x-ray diffraction | A, B | — | — |
| 2AKM | Fluoride inhibition of enolase: crystal structure of the inhibitory complex | x-ray diffraction | A, B | — | — |
| 2AKZ | Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex | x-ray diffraction | A, B | — | — |
| 2AKZ | Fluoride inhibition of enolase: crystal structure of the inhibitory complex | x-ray diffraction | A, B | — | — |
| 3UCC | Asymmetric complex of human neuron specific enolase-1-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UCC | Asymmetric complex of human neuron specific enolase-1-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UCD | Asymmetric complex of human neuron specific enolase-2-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UCD | Asymmetric complex of human neuron specific enolase-2-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJE | Asymmetric complex of human neuron specific enolase-3-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJE | Asymmetric complex of human neuron specific enolase-3-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJF | Asymmetric complex of human neuron specific enolase-4-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJF | Asymmetric complex of human neuron specific enolase-4-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJR | Asymmetric complex of human neuron specific enolase-5-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJR | Asymmetric complex of human neuron specific enolase-5-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJS | Asymmetric complex of human neuron specific enolase-6-PGA/PEP | x-ray diffraction | A, B | — | — |
| 3UJS | Asymmetric complex of human neuron specific enolase-6-PGA/PEP | x-ray diffraction | A, B | — | — |
| 4ZA0 | Structure of Human Enolase 2 in complex with Phosphonoacetohydroxamate | x-ray diffraction | A, B | MG, PAH | 9 (best 0.73) |
| 4ZA0 | Structure of human enolase 2 in complex with phosphonoacetohydroxamate | x-ray diffraction | A, B | — | — |
| 4ZCW | Structure of Human Enolase 2 in complex with SF2312 | x-ray diffraction | A, B | — | — |
| 4ZCW | Structure of human enolase 2 in complex with SF2312 | x-ray diffraction | A, B | — | — |
| 5EU9 | Structure of Human Enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)ph… | x-ray diffraction | A, B, C, D, E, F, G, H | MG, 5TX | — |
| 5EU9 | Structure of human enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5IDZ | Structure of Human Enolase 2 in complex with (S)-(1-hydroxy-2-oxopiperidin-3-yl)phosphonate | x-ray diffraction | A, B | MG, 6BM | — |
| 5IDZ | Structure of human enolase 2 in complex with (S)-(1-hydroxy-2- oxopiperidin-3-YL)PHOSPHONATE | x-ray diffraction | A, B | — | — |
| 5TD9 | Structure of human enolase 2 | x-ray diffraction | A, B | MG, CL | — |
| 5TIJ | Structure of Human Enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonate… | x-ray diffraction | A, B | 5TX, MG | 10 (best 0.74) |
| 5TIJ | Structure of human enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2- oxopyrrolidin-3-YL)PHOSPHONATE… | x-ray diffraction | A, B | 5TX, MG | — |
| 7MBH | Structure of Human Enolase 2 in complex with phosphoserine | x-ray diffraction | A, B | PO4, MG, SEP | 9 (best 0.74) |
| P09104 | AlphaFold monomer V2.0 prediction for gamma-enolase (P09104) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 7 records
- 5TX · ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid · in 3 records
- 6BM · [(3S)-1-hydroxy-2-oxopiperidin-3-yl]phosphonic acid · in 1 record
- CL · Chloride ion · in 1 record
- PAH · Phosphonoacetohydroxamic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
- SEP · Phosphoserine · in 1 record
Experiment against prediction
- 3UCD chain B against the predicted model P09104: TM-score 1.00, RMSD 0.40 Å
- 3UCD chain B against the predicted model P09104: TM-score 1.00, RMSD 0.40 Å
- 3UJE chain B against the predicted model P09104: TM-score 1.00, RMSD 0.42 Å
- 3UJE chain B against the predicted model P09104: TM-score 1.00, RMSD 0.42 Å
- 3UCC chain A against the predicted model P09104: TM-score 1.00, RMSD 0.44 Å
- 3UCC chain A against the predicted model P09104: TM-score 1.00, RMSD 0.44 Å
- 3UJS chain A against the predicted model P09104: TM-score 1.00, RMSD 0.45 Å
- 3UJS chain A against the predicted model P09104: TM-score 1.00, RMSD 0.45 Å
- 5EU9 chain D against the predicted model P09104: TM-score 1.00, RMSD 0.45 Å
- 5EU9 chain D against the predicted model P09104: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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