MolNFT v1 · #134713 · protein
Structure of human enolase 2
5TD9 · Gamma-enolase: “Structure of human enolase 2”. X-ray diffraction, 2 ligands (MG, CL), 8 pockets (best druggability 0.74). MolNFT v1 #134713 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TD9
- Type
- protein
- Length
- 868 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-enolase
- EC
- 4.2.1.11
- UniProt
- P09104
- Ligands
- MG, CL
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Gamma-enolase (EC 4.2.1.11) | protein | 434 | 44% helix, 16% strand | P09104 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1030 | 0.74 | 0.77 | 59 | empty |
| 2 | 404 | 0.64 | 0.78 | 60 | CL |
| 3 | 377 | 0.60 | 0.77 | 53 | CL |
| 4 | 67 | 0.43 | 0.82 | 16 | empty |
| 5 | 82 | 0.41 | 0.79 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1903 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- P09104 · AlphaFold monomer V2.0 prediction for gamma-enolase (P09104) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09104
- Elsewhere: RCSB PDB 5TD9 · PDBe 5TD9 · UniProt P09104
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