MolNFT v1 · #134895 · protein
Structure of human enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2- oxopyrrolidin-3-YL)PHOSPHONATE (purified enantiomer)
5TIJ · Gamma-enolase: “Structure of human enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2- oxopyrrolidin-3-YL)PHOSPHONATE (purified…”. X-ray diffraction, 2 ligands (5TX, MG), 10 pockets (best druggability 0.74). MolNFT v1 #134895 on…
- PDB
- 5TIJ
- Type
- protein
- Length
- 866 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-enolase
- EC
- 4.2.1.11
- UniProt
- P09104
- Ligands
- 5TX, MG
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Gamma-enolase (EC 4.2.1.11) | protein | 433 | 43% helix, 17% strand | P09104 |
Ligands and binding sites
- 5TX · ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1082 | 0.74 | 0.77 | 57 | empty |
| 2 | 71 | 0.71 | 0.97 | 26 | 5TX |
| 3 | 62 | 0.65 | 0.95 | 25 | 5TX |
| 4 | 203 | 0.56 | 0.79 | 37 | empty |
| 5 | 194 | 0.55 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1952 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 5TIJ · Structure of Human Enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)pho… · the same entry in another collection · chain A against A, TM-score 1.00
- P09104 · AlphaFold monomer V2.0 prediction for gamma-enolase (P09104) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09104
- Elsewhere: RCSB PDB 5TIJ · PDBe 5TIJ · UniProt P09104
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.