UniProt P08908
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A (P08908)
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A (UniProt P08908): 16 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08908
- Protein
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1A
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 55 · 13 records with a druggable one
Structures
17 records of P08908 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7E2X | Apo serotonin 1A (5-HT1A) receptor-Gi protein complex | electron microscopy | R | J40, CLR, PLM | 5 (best 0.75) |
| 7E2X | Apo serotonin 1A (5-HT1A) receptor-gi protein complex | electron microscopy | R | J40, CLR, PLM | — |
| 7E2Y | Serotonin-bound Serotonin 1A (5-HT1A) receptor-Gi protein complex | electron microscopy | R | SRO, J40, CLR | 5 (best 0.78) |
| 7E2Y | Serotonin-bound serotonin 1A (5-HT1A) receptor-gi protein complex | electron microscopy | R | SRO, J40, CLR | — |
| 7E2Z | Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex | electron microscopy | R | 9SC, CLR, J40 | 6 (best 0.80) |
| 7E2Z | Aripiprazole-bound serotonin 1A (5-HT1A) receptor-gi protein complex | electron microscopy | R | 9SC, CLR, J40 | — |
| 8FY8 | 5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | electron microscopy | R | YFW, J40, Y01 | 4 (best 0.75) |
| 8FYE | 4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | electron microscopy | R | YGH, J40, Y01 | 5 (best 0.76) |
| 8FYL | Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | electron microscopy | R | J40, YG7, Y01 | 4 (best 0.77) |
| 8FYT | LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | electron microscopy | R | 7LD, J40, Y01 | 3 (best 0.76) |
| 8FYX | Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | electron microscopy | R | YLX, J40, Y01 | 6 (best 0.78) |
| 8JSP | Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex | electron microscopy | R | UJL | 4 (best 0.77) |
| 8JT6 | 5-HT1A-Gi in complex with compound (R)-IHCH-7179 | electron microscopy | R | CLR, PLM, J40, EZX | 4 (best 0.78) |
| 8PJK | ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex | electron microscopy | R | CLR, ZL9, T7M | 3 (best 0.77) |
| 8PKM | Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex | electron microscopy | R | CLR, T7M, ZKV | 3 (best 0.78) |
| 8W8B | Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex | electron microscopy | R | CLR, PLM, UJL | 3 (best 0.77) |
| P08908 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 1A (P08908) | predicted | A | — | — |
Ligands
- J40 · [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E, 8E)-hexadeca-5,8,11,14-tetraenoate · in 12 records
- CLR · Cholesterol · in 10 records
- Y01 · Cholesterol hemisuccinate · in 5 records
- PLM · Palmitic acid · in 4 records
- 9SC · 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one · in 2 records
- SRO · Serotonin · in 2 records
- T7M · (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 2 records
- UJL · 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine · in 2 records
- 7LD · (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide · in 1 record
- EZX · 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one · in 1 record
- YFW · 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine · in 1 record
- YG7 · 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide · in 1 record
- YGH · 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole · in 1 record
- YLX · Buspirone · in 1 record
- ZKV · (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone · in 1 record
- ZL9 · 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one · in 1 record
Experiment against prediction
- 8PKM chain R against the predicted model P08908: TM-score 0.92, RMSD 2.18 Å
- 8FYX chain R against the predicted model P08908: TM-score 0.90, RMSD 2.37 Å
- 8FYT chain R against the predicted model P08908: TM-score 0.90, RMSD 2.22 Å
- 8FY8 chain R against the predicted model P08908: TM-score 0.90, RMSD 2.25 Å
- 8PJK chain R against the predicted model P08908: TM-score 0.90, RMSD 2.29 Å
- 8FYE chain R against the predicted model P08908: TM-score 0.90, RMSD 2.25 Å
- 8FYL chain R against the predicted model P08908: TM-score 0.90, RMSD 2.29 Å
- 8W8B chain R against the predicted model P08908: TM-score 0.90, RMSD 2.15 Å
- 7E2Z chain R against the predicted model P08908: TM-score 0.89, RMSD 2.24 Å
- 7E2Z chain R against the predicted model P08908: TM-score 0.89, RMSD 2.24 Å
Elsewhere
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