UniProt P07741
Adenine phosphoribosyltransferase (P07741)
Adenine phosphoribosyltransferase (UniProt P07741), EC 2.4.2.7: 30 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P07741
- Protein
- Adenine phosphoribosyltransferase
- EC
- 2.4.2.7
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 24 · 7 records with a druggable one
Structures
31 records of P07741 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ORE | Human Adenine Phosphoribosyltransferase | x-ray diffraction | A | — | — |
| 1ORE | Human adenine phosphoribosyltransferase | x-ray diffraction | A | — | — |
| 1ZN7 | Human Adenine Phosphoribosyltransferase Complexed with PRPP, ADE and R5P | x-ray diffraction | A, B | — | — |
| 1ZN7 | Human adenine phosphoribosyltransferase complexed with prpp, ade and R5P | x-ray diffraction | A, B | — | — |
| 1ZN8 | Human Adenine Phosphoribosyltransferase Complexed with AMP, in Space Group P1 at 1.76 A Resolution | x-ray diffraction | A, B | — | — |
| 1ZN8 | Human adenine phosphoribosyltransferase complexed with AMP, in space group P1 at 1.76 a resolution | x-ray diffraction | A, B | — | — |
| 1ZN9 | Human Adenine Phosphoribosyltransferase in Apo and AMP Complexed Forms | x-ray diffraction | A, B | — | — |
| 1ZN9 | Human adenine phosphoribosyltransferase in apo and AMP complexed forms | x-ray diffraction | A, B | — | — |
| 4X44 | Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase | x-ray diffraction | A | — | — |
| 4X44 | Crystal structure of mutant R89Q of human adenine phosphoribosyltransferase | x-ray diffraction | A | — | — |
| 4X45 | Crystal structure of F173G mutant of human aprt | x-ray diffraction | A, B | — | — |
| 6FCH | Crystal Structure of Human APRT wild type in complex with PRPP and Mg2+ | x-ray diffraction | A, B | MG, PRP | 3 (best 0.68) |
| 6FCH | Crystal structure of human aprt wild type in complex with prpp and MG2+ | x-ray diffraction | A, B | MG, PRP | — |
| 6FCI | Crystal Structure of Human APRT wild type in complex with Adenine, PRPP and Mg2+ | x-ray diffraction | A, B, C, D | MG, PRP, ADE | 5 (best 0.78) |
| 6FCI | Crystal structure of human aprt wild type in complex with adenine, prpp and MG2+ | x-ray diffraction | A, B, C, D | MG, PRP, ADE | — |
| 6FCL | Crystal Structure of Human APRT wild type in complex with AMP | x-ray diffraction | A, B | AMP | — |
| 6FCL | Crystal structure of human aprt wild type in complex with AMP | x-ray diffraction | A, B | AMP | — |
| 6FD4 | Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 hours… | x-ray diffraction | B, A | MG, PRP | 2 (best 0.72) |
| 6FD4 | Crystal structure of human aprt-TYR105PHE variant in complex with adenine, prpp and MG2+, 14 hours… | x-ray diffraction | B, A | MG, PRP | — |
| 6FD5 | Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days… | x-ray diffraction | A, B | AMP, PPV, MG, PRP | 3 (best 0.56) |
| 6FD5 | Crystal structure of human aprt-TYR105PHE variant in complex with adenine, prpp and MG2+, 14 days… | x-ray diffraction | A, B | AMP, PPV, PRP, MG | — |
| 6FD6 | Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 30 days… | x-ray diffraction | A, B | AMP, PPV, MG | 2 (best 0.75) |
| 6FD6 | Crystal structure of human aprt-TYR105PHE variant in complex with adenine, prpp and MG2+, 30 days… | x-ray diffraction | A, B | AMP, PPV | — |
| 6HGP | Crystal Structure of Human APRT wild type in complex with Phosphate ion. | x-ray diffraction | A, B | PO4 | — |
| 6HGP | Crystal structure of human aprt wild type in complex with phosphate ion. | x-ray diffraction | A, B | PO4 | — |
| 6HGQ | Crystal Structure of Human APRT wild type in complex with Hypoxanthine, PRPP and Mg2+ | x-ray diffraction | A, C, D, B | MG, PRP, HPA | 5 (best 0.79) |
| 6HGQ | Crystal structure of human aprt wild type in complex with hypoxanthine, prpp and MG2+ | x-ray diffraction | A, C, D, B | MG, PRP, HPA | — |
| 6HGR | Crystal Structure of Human APRT wild type in complex with IMP | x-ray diffraction | A, B | IMP | 4 (best 0.72) |
| 6HGR | Crystal structure of human aprt wild type in complex with imp | x-ray diffraction | A, B | IMP | — |
| 6HGS | Crystal structure of human aprt wild type in complex with gmp | x-ray diffraction | A, B | 5GP | — |
| P07741 | AlphaFold monomer V2.0 prediction for adenine phosphoribosyltransferase (P07741) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 11 records
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · in 10 records
- AMP · Adenosine monophosphate · in 6 records
- PPV · Pyrophosphate · in 4 records
- ADE · Adenine · in 2 records
- HPA · Hypoxanthine · in 2 records
- IMP · Inosinic acid · in 2 records
- PO4 · Phosphate ion · in 2 records
- 5GP · Guanosine-5'-monophosphate · in 1 record
Experiment against prediction
- 6FD5 chain B against the predicted model P07741: TM-score 1.00, RMSD 0.23 Å
- 6FD5 chain B against the predicted model P07741: TM-score 1.00, RMSD 0.23 Å
- 6HGP chain B against the predicted model P07741: TM-score 1.00, RMSD 0.26 Å
- 6HGP chain B against the predicted model P07741: TM-score 1.00, RMSD 0.26 Å
- 6FD4 chain B against the predicted model P07741: TM-score 1.00, RMSD 0.27 Å
- 6FD4 chain B against the predicted model P07741: TM-score 1.00, RMSD 0.27 Å
- 6FD4 chain A against the predicted model P07741: TM-score 1.00, RMSD 0.32 Å
- 6FD4 chain A against the predicted model P07741: TM-score 1.00, RMSD 0.32 Å
- 6HGS chain B against the predicted model P07741: TM-score 1.00, RMSD 0.30 Å
- 6HGR chain A against the predicted model P07741: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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