MolNFT v1 · #29911 · protein
Human adenine phosphoribosyltransferase complexed with AMP, in space group P1 at 1.76 a resolution
1ZN8: “Human adenine phosphoribosyltransferase complexed with AMP, in space group P1 at 1.76 a resolution”. X-ray diffraction, 2 ligands (AMP, CL), 3 pockets (best druggability 0.75). MolNFT v1 #29911 on GenesisL1: 3D structure, binding…
- PDB
- 1ZN8
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenine phosphoribosyltransferase
- EC
- 2.4.2.7
- UniProt
- P07741
- Ligands
- AMP, CL
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenine phosphoribosyltransferase (EC 2.4.2.7) | protein | 178 | 35% helix, 35% strand | P07741 |
| B | Adenine phosphoribosyltransferase (EC 2.4.2.7) | protein | 179 | 37% helix, 35% strand | P07741 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.75 | 0.79 | 65 | AMP |
| 2 | 51 | 0.46 | 0.85 | 14 | empty |
| 3 | 99 | 0.39 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1504 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 1ZN8 · Human Adenine Phosphoribosyltransferase Complexed with AMP, in Space Group P1 at 1.76 A… · the same entry in another collection · chain A against A, TM-score 1.00
- P07741 · AlphaFold monomer V2.0 prediction for adenine phosphoribosyltransferase (P07741) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07741
- Elsewhere: RCSB PDB 1ZN8 · PDBe 1ZN8 · UniProt P07741
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