MolNFT v1 · #109484 · protein
Crystal structure of mutant R89Q of human adenine phosphoribosyltransferase
4X44: “Crystal structure of mutant R89Q of human adenine phosphoribosyltransferase”. X-ray diffraction, 2 ligands (AMP, SO4), 1 pocket (best druggability 0.57). MolNFT v1 #109484 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4X44
- Type
- protein
- Length
- 177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenine phosphoribosyltransferase
- EC
- 2.4.2.7
- UniProt
- P07741
- Ligands
- AMP, SO4
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenine phosphoribosyltransferase (EC 2.4.2.7) | protein | 177 | 34% helix, 33% strand | P07741 |
Ligands and binding sites
- AMP · Adenosine monophosphate · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.57 | 0.76 | 32 | AMP, SO4, GOL |
Compared structures
- 4X44 · Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- P07741 · AlphaFold monomer V2.0 prediction for adenine phosphoribosyltransferase (P07741) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07741
- Elsewhere: RCSB PDB 4X44 · PDBe 4X44 · UniProt P07741
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