UniProt P07700
P07700
P07700 (UniProt P07700): 47 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07700
- Experimental structures
- 47
- Predicted models
- 1
- Ligands
- 8
Structures
48 records of P07700 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DEP | Membrane protein, NMR, 1 structure | solution nmr | A | — | — |
| 1DEP | Membrane protein, NMR, 1 structure | solution nmr | A | — | — |
| 2VT4 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound cyanopindolol | x-ray diffraction | A, B, C, D | — | — |
| 2VT4 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound cyanopindolol | x-ray diffraction | A, B, C, D | — | — |
| 2Y00 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine… | x-ray diffraction | A, B | — | — |
| 2Y00 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine… | x-ray diffraction | A, B | — | — |
| 2Y01 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine… | x-ray diffraction | A, B | — | — |
| 2Y01 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist dobutamine… | x-ray diffraction | A, B | — | — |
| 2Y02 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound agonist carmoterol | x-ray diffraction | A, B | — | — |
| 2Y02 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound agonist carmoterol | x-ray diffraction | A, B | — | — |
| 2Y03 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound agonist isoprenaline | x-ray diffraction | A, B | — | — |
| 2Y03 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound agonist isoprenaline | x-ray diffraction | A, B | — | — |
| 2Y04 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist salbutamol | x-ray diffraction | A, B | — | — |
| 2Y04 | Turkey BETA1 adrenergic receptor with stabilising mutations and bound partial agonist salbutamol | x-ray diffraction | A, B | — | — |
| 2YCW | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist carazolol | x-ray diffraction | A, B | — | — |
| 2YCW | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist carazolol | x-ray diffraction | A, B | — | — |
| 2YCX | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | x-ray diffraction | A, B | — | — |
| 2YCX | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | x-ray diffraction | A, B | — | — |
| 2YCY | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | x-ray diffraction | A, B | — | — |
| 2YCY | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist cyanopindolol | x-ray diffraction | A, B | — | — |
| 2YCZ | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist iodocyanopindolol | x-ray diffraction | A, B | — | — |
| 2YCZ | Turkey BETA1 adrenergic receptor with stabilising mutations and bound antagonist iodocyanopindolol | x-ray diffraction | A, B | — | — |
| 3ZPQ | Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound… | x-ray diffraction | A, B | — | — |
| 3ZPQ | Thermostabilised turkey BETA1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound… | x-ray diffraction | A, B | — | — |
| 3ZPR | Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound | x-ray diffraction | A, B | — | — |
| 3ZPR | Thermostabilised turkey BETA1 adrenergic receptor with 4-methyl-2- (piperazin-1-yl) quinoline bound | x-ray diffraction | A, B | — | — |
| 4AMI | Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol | x-ray diffraction | A, B | — | — |
| 4AMI | Turkey BETA1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol | x-ray diffraction | A, B | — | — |
| 4AMJ | Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol | x-ray diffraction | A, B | — | — |
| 4AMJ | Turkey BETA1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol | x-ray diffraction | A, B | — | — |
| 4BVN | Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound | x-ray diffraction | A | — | — |
| 4BVN | Ultra-thermostable BETA1-adrenoceptor with cyanopindolol bound | x-ray diffraction | A | — | — |
| 4GPO | Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor | x-ray diffraction | A, B | — | — |
| 4GPO | Oligomeic turkey BETA1-adrenergic G protein-coupled receptor | x-ray diffraction | A, B | — | — |
| 5A8E | thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol… | x-ray diffraction | A | — | — |
| 5A8E | Thermostabilised BETA1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol… | x-ray diffraction | A | — | — |
| 5F8U | Ligand occupancy in crystal structure of BETA1-adrenergic receptor previously submitted by huang et… | x-ray diffraction | B, A | — | — |
| 6H7J | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 | x-ray diffraction | A, B | 5FW, NA, 2CV | — |
| 6H7J | Activated turkey BETA1 adrenoceptor with bound agonist isoprenaline and nanobody NB80 | x-ray diffraction | A, B | 5FW, NA, 2CV | — |
| 6H7L | Activated turkey BETA1 adrenoceptor with bound partial agonist dobutamine and nanobody NB6B9 | x-ray diffraction | A, B | NA, 2CV, Y00 | — |
| 6H7M | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9 | x-ray diffraction | A, B | 2CV, 68H, NA | — |
| 6H7M | Activated turkey BETA1 adrenoceptor with bound partial agonist salbutamol and nanobody NB6B9 | x-ray diffraction | A, B | 2CV, 68H, NA | — |
| 6H7N | Activated turkey BETA1 adrenoceptor with bound partial agonist xamoterol and nanobody NB6B9 | x-ray diffraction | A, B | FVK, NA, 2CV | — |
| 6H7O | ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9 | x-ray diffraction | A, B | P32, NA, 2CV | — |
| 6H7O | Activated turkey BETA1 adrenoceptor with bound weak partial agonist cyanopindolol and nanobody NB6B9 | x-ray diffraction | A, B | P32, NA, 2CV | — |
| 6IBL | Activated turkey BETA1 adrenoceptor with bound agonist formoterol and nanobody NB80 | x-ray diffraction | A, B | H98, NA, 2CV | — |
| 6TKO | Phosphorylated turkey BETA1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in… | electron microscopy | A | H98 | — |
| P07700 | AlphaFold monomer V2.0 prediction for beta-1 adrenergic receptor (P07700) | predicted | A | — | — |
Ligands
- 2CV · Hega-10 · in 9 records
- NA · Sodium ion · in 9 records
- 5FW · Isoprenaline · in 2 records
- 68H · Salbutamol · in 2 records
- H98 · ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide · in 2 records
- P32 · 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile · in 2 records
- FVK · ~{N}-[2-[[(2~{S})-2-oxidanyl-3-(4-oxidanylphenoxy) propyl]amino]ethyl]morpholine-4-carboxamide · in 1 record
- Y00 · Dobutamine · in 1 record
Experiment against prediction
- 4AMI chain B against the predicted model P07700: TM-score 0.99, RMSD 0.63 Å
- 4AMI chain B against the predicted model P07700: TM-score 0.99, RMSD 0.63 Å
- 4AMI chain A against the predicted model P07700: TM-score 0.99, RMSD 0.71 Å
- 4AMI chain A against the predicted model P07700: TM-score 0.99, RMSD 0.71 Å
- 3ZPR chain A against the predicted model P07700: TM-score 0.99, RMSD 0.73 Å
- 3ZPR chain A against the predicted model P07700: TM-score 0.99, RMSD 0.73 Å
- 2Y00 chain A against the predicted model P07700: TM-score 0.99, RMSD 0.74 Å
- 2Y00 chain A against the predicted model P07700: TM-score 0.99, RMSD 0.74 Å
- 2YCW chain B against the predicted model P07700: TM-score 0.99, RMSD 0.79 Å
- 2YCW chain B against the predicted model P07700: TM-score 0.99, RMSD 0.79 Å
Elsewhere
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