UniProt P07014
Succinate dehydrogenase iron-sulfur subunit (P07014)
Succinate dehydrogenase iron-sulfur subunit (UniProt P07014), EC 1.3.5.1, 1.3.99.1: 22 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 29 pockets. Binding sites, druggability and experiment against…
- UniProt
- P07014
- Protein
- Succinate dehydrogenase iron-sulfur subunit
- EC
- 1.3.5.1, 1.3.99.1
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 29 · 3 records with a druggable one
Structures
23 records of P07014 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NEK | Complex II (Succinate Dehydrogenase) From E. Coli with ubiqui bound | x-ray diffraction | B | FAD, CA, FES, SF4, F3S, HEM | 6 (best 0.86) |
| 1NEK | Complex II (succinate dehydrogenase) from E. COLI with ubiquinone bound | x-ray diffraction | B | — | — |
| 1NEN | Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized… | x-ray diffraction | B | FAD, CA, FES, SF4, F3S, HEM | 8 (best 0.86) |
| 1NEN | Complex II (succinate dehydrogenase) from E. COLI with dinitrophenol-17 inhibitor co-crystallized… | x-ray diffraction | B | — | — |
| 2ACZ | Complex II (Succinate Dehydrogenase) From E. Coli with Atpenin A5 inhibitor co-crystallized at the… | x-ray diffraction | B | — | — |
| 2ACZ | Complex II (succinate dehydrogenase) from E. COLI with atpenin A5 inhibitor co-crystallized at the… | x-ray diffraction | B | — | — |
| 2WDQ | E. coli succinate:qui oxidoreductase (SQR) with carboxin bound | x-ray diffraction | B, F, J | — | — |
| 2WDQ | E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) with carboxin bound | x-ray diffraction | B, F, J | — | — |
| 2WDR | E. coli succinate:qui oxidoreductase (SQR) with pentachlorophenol bound | x-ray diffraction | B, F, J | — | — |
| 2WDR | E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) with pentachlorophenol bound | x-ray diffraction | B, F, J | — | — |
| 2WDV | E. coli succinate:qui oxidoreductase (SQR) with an empty qui - binding pocket | x-ray diffraction | B, F, J | — | — |
| 2WDV | E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) with an empty quinone-binding pocket | x-ray diffraction | B, F, J | — | — |
| 2WP9 | Crystal structure of the E. coli succinate:qui oxidoreductase (SQR) SdhB His207Thr mutant | x-ray diffraction | B, F, J | — | — |
| 2WP9 | Crystal structure of the E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) sdhb HIS207THR mutant | x-ray diffraction | B, F, J | — | — |
| 2WS3 | Crystal structure of the E. coli succinate:qui oxidoreductase (SQR) SdhD Tyr83Phe mutant | x-ray diffraction | B, F, J | — | — |
| 2WS3 | Crystal structure of the E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) sdhd TYR83PHE mutant | x-ray diffraction | B, F, J | — | — |
| 2WU2 | Crystal structure of the E. coli succinate:qui oxidoreductase (SQR) SdhC His84Met mutant | x-ray diffraction | B, F, J | — | — |
| 2WU2 | Crystal structure of the E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) sdhc HIS84MET mutant | x-ray diffraction | B, F, J | — | — |
| 2WU5 | Crystal structure of the E. coli succinate:qui oxidoreductase (SQR) SdhD His71Met mutant | x-ray diffraction | B, F, J | — | — |
| 2WU5 | Crystal structure of the E. COLI SUCCINATE:QUINONE oxidoreductase (sqr) sdhd HIS71MET mutant | x-ray diffraction | B, F, J | — | — |
| 7JZ2 | Succinate: qui oxidoreductase SQR from E.coli K12 | electron microscopy | B, F, J | FES, SF4, F3S, HEM, UQ2 | 15 (best 0.88) |
| 7JZ2 | Succinate: quinone oxidoreductase sqr from E.COLI K12 | electron microscopy | B, F, J | FES, SF4, F3S, HEM, UQ2 | — |
| P07014 | AlphaFold monomer V2.0 prediction for succinate dehydrogenase iron- sulfur subunit (P07014) | predicted | A | — | — |
Ligands
- F3S · FE3-S4 cluster · in 4 records
- FES · Fe2/s2 (inorganic) cluster · in 4 records
- HEM · Protoporphyrin IX containing Fe · in 4 records
- SF4 · Iron/sulfur cluster · in 4 records
- UQ2 · Ubiquinone-2 · in 3 records
- CA · Calcium ion · in 2 records
- FAD · Flavin-adenine dinucleotide · in 2 records
- DNT · 2-[1-methylhexyl]-4,6-dinitrophenol · in 1 record
Experiment against prediction
- 2WDQ chain B against the predicted model P07014: TM-score 0.99, RMSD 0.50 Å
- 2WDQ chain B against the predicted model P07014: TM-score 0.99, RMSD 0.50 Å
- 2WU2 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.50 Å
- 2WU2 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.50 Å
- 2WU5 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.51 Å
- 2WU5 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.51 Å
- 2WS3 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.51 Å
- 2WS3 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.51 Å
- 2WP9 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.52 Å
- 2WP9 chain B against the predicted model P07014: TM-score 0.99, RMSD 0.52 Å
Elsewhere
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