UniProt P05725
DNA endonuclease I-CreI (P05725)
DNA endonuclease I-CreI (UniProt P05725), EC 3.1.-.-: 58 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 284 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05725
- Protein
- DNA endonuclease I-CreI
- EC
- 3.1.-.-
- Experimental structures
- 58
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 284 · 54 records with a druggable one
Structures
59 records of P05725 in the MolNFT archive: 58 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AF5 | Group I mobile intron endonuclease | x-ray diffraction | A | — | 1 (best 0.29) |
| 1AF5 | Group I mobile intron endonuclease | x-ray diffraction | A | — | 1 (best 0.29) |
| 1BP7 | Group I mobile intron endonuclease I-crei complexed with homing site DNA | x-ray diffraction | A, B, C, D | CA | 7 (best 0.72) |
| 1BP7 | Group I mobile intron endonuclease I-crei complexed with homing site DNA | x-ray diffraction | A, B, C, D | CA | 7 (best 0.72) |
| 1G9Y | Homing endonuclease I-crei / DNA substrate complex with calcium | x-ray diffraction | A, B | CA | 4 (best 0.76) |
| 1G9Y | Homing endonuclease I-crei / DNA substrate complex with calcium | x-ray diffraction | A, B | CA | 4 (best 0.76) |
| 1G9Z | Laglidadg homing endonuclease I-crei / DNA product complex with magnesium | x-ray diffraction | A, B | MG | 2 (best 0.71) |
| 1G9Z | Laglidadg homing endonuclease I-crei / DNA product complex with magnesium | x-ray diffraction | A, B | MG | 2 (best 0.71) |
| 1MOW | E-DreI | x-ray diffraction | A, D, G, J | MG, SO4 | 17 (best 0.85) |
| 1MOW | E-DREI | x-ray diffraction | A, D, G, J | MG, SO4 | 17 (best 0.85) |
| 1N3E | Crystal structure of I-CreI bound to a palindromic DNA sequence I (palindrome of left side of… | x-ray diffraction | A, B, G, H | CA, NA | 11 (best 0.66) |
| 1N3E | Crystal structure of I-crei bound to a palindromic DNA sequence I (palindrome of left side of… | x-ray diffraction | A, B, G, H | CA, NA | 11 (best 0.66) |
| 1N3F | Crystal structure of I-CreI bound to a palindromic DNA sequence II (palindrome of right side of… | x-ray diffraction | A, B, G, H | CA | 8 (best 0.77) |
| 1N3F | Crystal structure of I-crei bound to a palindromic DNA sequence II (palindrome of right side of… | x-ray diffraction | A, B, G, H | CA | 8 (best 0.77) |
| 1T9I | I-CreI(D20N)/DNA complex | x-ray diffraction | A, B | CA, NA | 4 (best 0.75) |
| 1T9I | I-CREI(D20N)/DNA complex | x-ray diffraction | A, B | CA, NA | 4 (best 0.75) |
| 1T9J | I-CreI(Q47E)/DNA complex | x-ray diffraction | A, B | — | 4 (best 0.72) |
| 1T9J | I-CREI(Q47E)/DNA complex | x-ray diffraction | A, B | — | 4 (best 0.72) |
| 1U0C | Y33C Mutant of Homing endonuclease I-CreI | x-ray diffraction | A, B | MG | 3 (best 0.70) |
| 1U0C | Y33C mutant of homing endonuclease I-crei | x-ray diffraction | A, B | MG | 3 (best 0.70) |
| 1U0D | Y33H Mutant of Homing endonuclease I-CreI | x-ray diffraction | A, B | — | 4 (best 0.75) |
| 1U0D | Y33H mutant of homing endonuclease I-crei | x-ray diffraction | A, B | — | 4 (best 0.75) |
| 2I3P | K28R mutant of Homing Endonuclease I-CreI | x-ray diffraction | A, B | CA | 3 (best 0.74) |
| 2I3P | K28R mutant of homing endonuclease I-crei | x-ray diffraction | A, B | CA | 3 (best 0.74) |
| 2I3Q | Q44V mutant of Homing Endonuclease I-CreI | x-ray diffraction | A, B | CA | 4 (best 0.75) |
| 2I3Q | Q44V mutant of homing endonuclease I-crei | x-ray diffraction | A, B | CA | 4 (best 0.75) |
| 2O7M | The C-terminal loop of the homing endonuclease I-CreI is essential for DNA binding and cleavage.… | x-ray diffraction | A, B | — | 6 (best 0.43) |
| 2O7M | The C-terminal loop of the homing endonuclease I-crei is essential for DNA binding and cleavage.… | x-ray diffraction | A, B | — | 6 (best 0.43) |
| 2VBJ | Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | CA | 5 (best 0.78) |
| 2VBJ | Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | CA | 5 (best 0.78) |
| 2VBL | Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | MG | 3 (best 0.77) |
| 2VBL | Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | MG | 3 (best 0.77) |
| 2VBN | Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | MG, CA | 7 (best 0.67) |
| 2VBN | Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | MG, CA | 7 (best 0.67) |
| 2VBO | Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | CA | 7 (best 0.73) |
| 2VBO | Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease… | x-ray diffraction | A, B | CA | 7 (best 0.73) |
| 4AAB | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target (The four central… | x-ray diffraction | A, B | MG | 4 (best 0.77) |
| 4AAB | Crystal structure of the mutant D75N I-crei in complex with its wild-type target (the four central… | x-ray diffraction | A, B | MG | 4 (best 0.77) |
| 4AAD | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in absence of… | x-ray diffraction | A, B | — | 3 (best 0.80) |
| 4AAD | Crystal structure of the mutant D75N I-crei in complex with its wild-type target in absence of… | x-ray diffraction | A, B | — | 3 (best 0.80) |
| 4AAE | Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central… | x-ray diffraction | A, B | — | 3 (best 0.81) |
| 4AAE | Crystal structure of the mutant D75N I-crei in complex with an altered target (the four central… | x-ray diffraction | A, B | — | 3 (best 0.81) |
| 4AAF | Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central… | x-ray diffraction | A, B | — | 3 (best 0.81) |
| 4AAF | Crystal structure of the mutant D75N I-crei in complex with an altered target (the four central… | x-ray diffraction | A, B | — | 3 (best 0.81) |
| 4AAG | Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in presence of Ca… | x-ray diffraction | A, B | CA | 5 (best 0.75) |
| 4AAG | Crystal structure of the mutant D75N I-crei in complex with its wild-type target in presence of ca… | x-ray diffraction | A, B | CA | 5 (best 0.75) |
| 4AQU | Crystal structure of I-CreI complexed with its target methylated at position plus 2 (in the b… | x-ray diffraction | A, B | CA | 4 (best 0.73) |
| 4AQU | Crystal structure of I-crei complexed with its target methylated at position plus 2 (in the B… | x-ray diffraction | A, B | CA | 4 (best 0.73) |
| 4AQX | Crystal structure of I-CreI complexed with its target methylated at position plus 2 (in the b… | x-ray diffraction | A, B | MG | 3 (best 0.70) |
| 4AQX | Crystal structure of I-crei complexed with its target methylated at position plus 2 (in the B… | x-ray diffraction | A, B | MG | 3 (best 0.70) |
| 6FB2 | Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with… | x-ray diffraction | A, B | MN | 3 (best 0.77) |
| 6FB2 | Crystal structure of a tailored I-crei homing endonuclease protein (3115 variant) in complex with… | x-ray diffraction | A, B | MN | 3 (best 0.77) |
| 6FB7 | Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with its target DNA in… | x-ray diffraction | A, B | MN | 3 (best 0.71) |
| 6FB7 | Crystal structure of the I-crei homing endonuclease D75N variant in complex with its target DNA in… | x-ray diffraction | A, B | MN | 3 (best 0.71) |
| 6FB8 | Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with an altered version… | x-ray diffraction | A, B | MG | 6 (best 0.75) |
| 6FB8 | Crystal structure of the I-crei homing endonuclease D75N variant in complex with an altered version… | x-ray diffraction | A, B | MG | 6 (best 0.75) |
| 6FB9 | Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with an altered version… | x-ray diffraction | A, B | MN | 5 (best 0.77) |
| 6FB9 | Crystal structure of the I-crei homing endonuclease D75N variant in complex with an altered version… | x-ray diffraction | A, B | MN | 5 (best 0.77) |
| P05725 | AlphaFold monomer V2.0 prediction for DNA endonuclease I-crei (P05725) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1T9I chain B against the predicted model P05725: TM-score 1.00, RMSD 0.24 Å
- 1T9I chain B against the predicted model P05725: TM-score 1.00, RMSD 0.24 Å
- 1T9J chain A against the predicted model P05725: TM-score 1.00, RMSD 0.26 Å
- 1T9J chain A against the predicted model P05725: TM-score 1.00, RMSD 0.26 Å
- 1T9J chain B against the predicted model P05725: TM-score 1.00, RMSD 0.27 Å
- 1T9J chain B against the predicted model P05725: TM-score 1.00, RMSD 0.27 Å
- 1T9I chain A against the predicted model P05725: TM-score 1.00, RMSD 0.28 Å
- 1T9I chain A against the predicted model P05725: TM-score 1.00, RMSD 0.28 Å
- 2VBO chain A against the predicted model P05725: TM-score 1.00, RMSD 0.30 Å
- 2VBO chain A against the predicted model P05725: TM-score 1.00, RMSD 0.30 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.