UniProt P05067
Amyloid-beta precursor protein (P05067)
Amyloid-beta precursor protein (UniProt P05067): 319 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 146 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05067
- Protein
- Amyloid-beta precursor protein
- Experimental structures
- 319
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 146 · 28 records with a druggable one
Structures
320 records of P05067 in the MolNFT archive: 319 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AAP | X-ray crystal structure of the protease inhibitor domain of ALZHEIMER'S amyloid beta-protein… | x-ray diffraction | A, B | — | — |
| 1AAP | X-ray crystal structure of the protease inhibitor domain of ALZHEIMER'S amyloid beta-protein… | x-ray diffraction | A, B | — | — |
| 1AMB | Solution structure of residues 1-28 of the amyloid beta-peptide | solution nmr | A | — | — |
| 1AMB | Solution structure of residues 1-28 of the amyloid beta-peptide | solution nmr | A | — | — |
| 1AMC | Solution structure of residues 1-28 of the amyloid beta-peptide | solution nmr | A | — | — |
| 1AMC | Solution structure of residues 1-28 of the amyloid beta-peptide | solution nmr | A | — | — |
| 1AML | The ALZHEIMER`S disease amyloid A4 peptide (residues 1-40) | solution nmr | A | — | — |
| 1AML | The ALZHEIMER`S disease amyloid A4 peptide (residues 1-40) | solution nmr | A | — | — |
| 1BA4 | The solution structure of amyloid beta-peptide (1-40) in a water-micelle environment. is the… | solution nmr | A | — | — |
| 1BA4 | The solution structure of amyloid beta-peptide (1-40) in a water- micelle environment. is the… | solution nmr | A | — | — |
| 1BA6 | Solution structure of the methionine-oxidized amyloid beta-peptide (1-40). does oxidation affect… | solution nmr | A | — | — |
| 1BA6 | Solution structure of the methionine-oxidized amyloid beta-peptide (1- 40). does oxidation affect… | solution nmr | A | — | — |
| 1BJB | Solution NMR structure of amyloid BETA[E16], residues 1-28, 14 structures | solution nmr | A | — | — |
| 1BJB | Solution NMR structure of amyloid BETA[E16], residues 1-28, 14 structures | solution nmr | A | — | — |
| 1BJC | Solution NMR structure of amyloid BETA[F16], residues 1-28, 15 structures | solution nmr | A | — | — |
| 1BJC | Solution NMR structure of amyloid BETA[F16], residues 1-28, 15 structures | solution nmr | A | — | — |
| 1BRC | Relocating a negative charge in the binding pocket of trypsin | x-ray diffraction | I | — | — |
| 1BRC | Relocating a negative charge in the binding pocket of trypsin | x-ray diffraction | I | — | — |
| 1CA0 | Bovine chymotrypsin complexed to appi | x-ray diffraction | D, I | — | — |
| 1CA0 | Bovine chymotrypsin complexed to appi | x-ray diffraction | D, I | — | — |
| 1HZ3 | ALZHEIMER'S disease amyloid-beta peptide (residues 10-35) | solution nmr | A | — | — |
| 1HZ3 | ALZHEIMER'S disease amyloid-beta peptide (residues 10-35) | solution nmr | A | — | — |
| 1IYT | Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42) | solution nmr | A | — | — |
| 1IYT | Solution structure of the ALZHEIMER'S disease amyloid beta-peptide (1- 42) | solution nmr | A | — | — |
| 1MWP | N-terminal domain of the amyloid precursor protein | x-ray diffraction | A | — | — |
| 1MWP | N-terminal domain of the amyloid precursor protein | x-ray diffraction | A | — | — |
| 1OWT | Structure of the Alzheimer's disease amyloid precursor protein copper binding domain | solution nmr | A | — | — |
| 1OWT | Structure of the ALZHEIMER'S disease amyloid precursor protein copper binding domain | solution nmr | A | — | — |
| 1QCM | Amyloid beta peptide (25-35), NMR, 20 structures | solution nmr | A | — | — |
| 1QCM | Amyloid beta peptide (25-35), NMR, 20 structures | solution nmr | A | — | — |
| 1QWP | NMR analysis of 25-35 fragment of beta amyloid peptide | solution nmr | A | — | — |
| 1QWP | NMR analysis of 25-35 fragment of beta amyloid peptide | solution nmr | A | — | — |
| 1QXC | NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 v:v… | solution nmr | A | — | — |
| 1QXC | NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 V:V… | solution nmr | A | — | — |
| 1QYT | Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution | solution nmr | A | — | — |
| 1QYT | Solution structure of fragment (25-35) of beta amyloid peptide in sds micellar solution | solution nmr | A | — | — |
| 1TAW | Bovine trypsin complexed to appi | x-ray diffraction | B | — | — |
| 1TAW | Bovine trypsin complexed to appi | x-ray diffraction | B | — | — |
| 1TKN | Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta… | solution nmr | A | — | — |
| 1TKN | Solution structure of cappd*, an independently folded extracellular domain of human amyloid-beta… | solution nmr | A | — | — |
| 1X11 | X11 ptb domain | x-ray diffraction | C, D | — | — |
| 1X11 | X11 ptb domain | x-ray diffraction | C, D | — | — |
| 1Z0Q | Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) | solution nmr | A | — | — |
| 1Z0Q | Aqueous solution structure of the ALZHEIMER'S disease abeta peptide (1-42) | solution nmr | A | — | — |
| 1ZE7 | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5 | solution nmr | A | — | — |
| 1ZE7 | Zinc-binding domain of ALZHEIMER'S disease amyloid beta-peptide in water solution at pH 6.5 | solution nmr | A | — | — |
| 1ZE9 | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation | solution nmr | A | — | — |
| 1ZE9 | Zinc-binding domain of ALZHEIMER'S disease amyloid beta-peptide complexed with a zinc (II) cation | solution nmr | A | — | — |
| 1ZJD | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease… | x-ray diffraction | B | — | — |
| 1ZJD | Crystal structure of the catalytic domain of coagulation factor XI in complex with kunitz protease… | x-ray diffraction | B | — | — |
| 2BEG | 3D Structure of Alzheimer's Abeta(1-42) fibrils | solution nmr | A, B, C, D, E | — | — |
| 2BEG | 3D structure of ALZHEIMER'S ABETA(1-42) fibrils | solution nmr | A, B, C, D, E | — | — |
| 2BP4 | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution | solution nmr | A | — | — |
| 2BP4 | Zinc-binding domain of ALZHEIMER'S disease amyloid beta- peptide in tfe-water (80-20) solution | solution nmr | A | — | — |
| 2FJZ | Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to… | x-ray diffraction | A | — | — |
| 2FJZ | Structure of the ALZHEIMER'S amyloid precursor protein (app) copper binding domain (residues 133 to… | x-ray diffraction | A | — | — |
| 2FK1 | Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit… | x-ray diffraction | A | — | — |
| 2FK1 | Structure of the ALZHEIMER'S amyloid precursor protein (app) copper binding domain in 'small unit… | x-ray diffraction | A | — | — |
| 2FK2 | Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit… | x-ray diffraction | A | — | — |
| 2FK2 | Structure of the ALZHEIMER'S amyloid precursor protein (app) copper binding domain in 'small unit… | x-ray diffraction | A | — | — |
260 records more on the page itself.
Ligands
- CL · Chloride ion · in 3 records
- SO4 · Sulfate ion · in 3 records
- UNX · Unknown atom or ion · in 3 records
- 2PO · Phosphonate · in 2 records
- ACE · Acetyl group · in 2 records
- JEF · O-(O-(2-aminopropyl)-O'-(2-methoxyethyl)polypropylene glycol 500) · in 2 records
- NA · Sodium ion · in 2 records
- NH2 · Amino group · in 2 records
- PO4 · Phosphate ion · in 2 records
- ZN · Zinc ion · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- VW6 · 4-[2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethyl]-~{N}-methyl-aniline · in 1 record
Experiment against prediction
- 6XOV chain B against the predicted model P05067: TM-score 1.00, RMSD 0.02 Å
- 6XOV chain B against the predicted model P05067: TM-score 1.00, RMSD 0.02 Å
- 3SV1 chain F against the predicted model P05067: TM-score 1.00, RMSD 0.02 Å
- 3SV1 chain F against the predicted model P05067: TM-score 1.00, RMSD 0.02 Å
- 4M1C chain H against the predicted model P05067: TM-score 1.00, RMSD 0.03 Å
- 4M1C chain H against the predicted model P05067: TM-score 1.00, RMSD 0.03 Å
- 4PWQ chain B against the predicted model P05067: TM-score 0.98, RMSD 0.74 Å
- 4PWQ chain B against the predicted model P05067: TM-score 0.98, RMSD 0.74 Å
- 3L33 chain G against the predicted model P05067: TM-score 0.98, RMSD 0.37 Å
- 3L33 chain G against the predicted model P05067: TM-score 0.98, RMSD 0.37 Å
Elsewhere
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