UniProt P04958
Tetanus toxin (P04958)
Tetanus toxin (UniProt P04958), EC 3.4.24.68: 40 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 128 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04958
- Protein
- Tetanus toxin
- EC
- 3.4.24.68
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 128 · 13 records with a druggable one
Structures
41 records of P04958 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A8D | Tetanus toxin C fragment | x-ray diffraction | A | AU | 5 (best 0.49) |
| 1A8D | Tetanus toxin C fragment | x-ray diffraction | A | — | — |
| 1AF9 | Tetanus neurotoxin C fragment | x-ray diffraction | A | — | 4 (best 0.48) |
| 1AF9 | Tetanus neurotoxin C fragment | x-ray diffraction | A | — | — |
| 1D0H | The hc fragment of tetanus toxin complexed with N-acetyl-galactosamine | x-ray diffraction | A | A2G, SO4 | 5 (best 0.58) |
| 1D0H | The hc fragment of tetanus toxin complexed with N-acetyl-galactosamine | x-ray diffraction | A | — | — |
| 1DFQ | The hc fragment of tetanus toxin complexed with sialic acid | x-ray diffraction | A | SLB | 5 (best 0.54) |
| 1DFQ | The hc fragment of tetanus toxin complexed with sialic acid | x-ray diffraction | A | — | — |
| 1DIW | The hc fragment of tetanus toxin complexed with galactose | x-ray diffraction | A | GAL | 8 (best 0.57) |
| 1DIW | The hc fragment of tetanus toxin complexed with galactose | x-ray diffraction | A | — | — |
| 1DLL | The HC fragement of tetanus toxin complexed with lactose | x-ray diffraction | A | BGC, GAL | 6 (best 0.57) |
| 1DLL | The hc fragement of tetanus toxin complexed with lactose | x-ray diffraction | A | — | — |
| 1FV2 | The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B | x-ray diffraction | A | GAL, NGA, SIA, PO4 | 7 (best 0.53) |
| 1FV2 | The hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B | x-ray diffraction | A | — | — |
| 1FV3 | The hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B | x-ray diffraction | A, B | BGC, GAL, NGA, SIA, SLB, PO4 | 12 (best 0.56) |
| 1FV3 | The hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B | x-ray diffraction | A, B | — | — |
| 1YVG | Structural analysis of the catalytic domain of tetanus neurotoxin | x-ray diffraction | A | ZN | 1 (best 0.59) |
| 1YVG | Structural analysis of the catalytic domain of tetanus neurotoxin | x-ray diffraction | A | — | — |
| 1YXW | A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin | x-ray diffraction | A | — | 6 (best 0.48) |
| 1YXW | A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin | x-ray diffraction | A | — | — |
| 1YYN | A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin | x-ray diffraction | A | SIA | 4 (best 0.48) |
| 1YYN | A common binding site for disialyllactose and a tri-peptide in the C- fragment of tetanus neurotoxin | x-ray diffraction | A | — | — |
| 1Z7H | 2.3 Angstrom crystal structure of tetanus neurotoxin light chain | x-ray diffraction | A | ZN | 1 (best 0.69) |
| 1Z7H | 2.3 ångström crystal structure of tetanus neurotoxin light chain | x-ray diffraction | A | — | — |
| 3HMY | Crystal structure of HCR/T complexed with GT2 | x-ray diffraction | A | — | — |
| 3HMY | Crystal structure of HCR/T complexed with GT2 | x-ray diffraction | A | — | — |
| 3HN1 | Crystal structure of HCR/T complexed with GT2 and lactose | x-ray diffraction | A | — | — |
| 3HN1 | Crystal structure of HCR/T complexed with GT2 and lactose | x-ray diffraction | A | — | — |
| 4J1L | Mutant Endotoxin TeNT | x-ray diffraction | A | — | — |
| 4J1L | Mutant endotoxin tent | x-ray diffraction | A | — | — |
| 5N0B | Crystal structure of the tetanus neurotoxin in complex with GD1a | x-ray diffraction | A | GAL, NGA, SIA, ZN | — |
| 5N0B | Crystal structure of the tetanus neurotoxin in complex with GD1A | x-ray diffraction | A | GAL, NGA, SIA, ZN | — |
| 5N0C | Crystal structure of the tetanus neurotoxin in complex with GM1a | x-ray diffraction | A, B | GAL, NGA, SIA, ZN | 20 (best 0.83) |
| 5N0C | Crystal structure of the tetanus neurotoxin in complex with GM1A | x-ray diffraction | A, B | GAL, NGA, SIA, ZN | — |
| 7BXX | Tetanus neurotoxin translocation domain -C467S | x-ray diffraction, solution scattering | A, B | — | 3 (best 0.54) |
| 7BXX | Tetanus neurotoxin translocation domain -C467S | x-ray diffraction; solution scattering | A, B | — | — |
| 7BY4 | Tetanus neurotoxin receptor binding domain | x-ray diffraction | A | NA | 6 (best 0.53) |
| 7BY4 | Tetanus neurotoxin receptor binding domain | x-ray diffraction | A | NA | — |
| 7BY5 | Tetanus neurotoxin mutant-(H233A/E234Q/H237A/Y375F) | x-ray diffraction | A | NA, CL | 15 (best 0.84) |
| 7BY5 | Tetanus neurotoxin mutant-(H233A/E234Q/H237A/Y375F) | x-ray diffraction | A | NA, CL | — |
| P04958 | AlphaFold monomer V2.0 prediction for tetanus toxin (P04958) | predicted | A | — | 20 (best 0.82) |
Ligands
- GAL · beta-D-galactopyranose · in 8 records
- SIA · N-acetyl-alpha-neuraminic acid · in 7 records
- NGA · 2-acetamido-2-deoxy-beta-D-galactopyranose · in 6 records
- ZN · Zinc ion · in 6 records
- NA · Sodium ion · in 4 records
- BGC · beta-D-glucopyranose · in 2 records
- CL · Chloride ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SLB · N-acetyl-beta-neuraminic acid · in 2 records
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · in 1 record
- AU · Gold ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5N0C chain A against the predicted model P04958: TM-score 1.00, RMSD 0.43 Å
- 5N0C chain A against the predicted model P04958: TM-score 1.00, RMSD 0.43 Å
- 5N0C chain B against the predicted model P04958: TM-score 1.00, RMSD 0.70 Å
- 5N0C chain B against the predicted model P04958: TM-score 1.00, RMSD 0.70 Å
- 5N0B chain A against the predicted model P04958: TM-score 1.00, RMSD 0.76 Å
- 5N0B chain A against the predicted model P04958: TM-score 1.00, RMSD 0.76 Å
- 1DFQ chain A against the predicted model P04958: TM-score 0.99, RMSD 0.82 Å
- 1DFQ chain A against the predicted model P04958: TM-score 0.99, RMSD 0.82 Å
- 1D0H chain A against the predicted model P04958: TM-score 0.99, RMSD 0.81 Å
- 1D0H chain A against the predicted model P04958: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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